Down-regulation Of CXCR4 Expression In Bone Marrow-derived Mesenchymal Stem Cells (BM-MSCs) In Patients With Chronic Obstructive Pulmonary Disease (COPD): Preliminary Results

Author(s):  
Konstantinos Karagiannis ◽  
Katerina M. Antoniou ◽  
Rena Lymbouridou ◽  
Athanasia Proklou ◽  
Christina Kalpadaki ◽  
...  
2018 ◽  
Vol 1 (70) ◽  
pp. 121-128
Author(s):  
Сергей Целуйко ◽  
Sergey Tseluyko ◽  
А Яценко ◽  
A Yacenko ◽  
Е Устинов ◽  
...  

Current methods of treatment of chronic obstructive pulmonary disease are not effective enough and lead to the progression of the disease and disability of the patient. One of the promising methods of chronic obstructive pulmonary disease therapy is the use of the possibilities of regenerative medicine, in particular, mesenchymal stem cells. The review demonstrates the achievements of research groups developing approaches to chronic obstructive pulmonary disease therapy based on mesenchymal stem cells. Our attention was focused on the problems and possible ways to show the mechanism of action of mesenchymal stem cells. The issues of safety of mesenchymal stem cells application are also discussed.


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