Inhibition Of Mer Receptor Tyrosine Kinase Aggravates LPS-Induced Acute Lung Injury Through Blocking STAT1-Induced SOCS3

2011 ◽  
Author(s):  
Ye-Ji Lee ◽  
Ji-Young Han ◽  
Jihee L. Kang
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase

The Role of the Receptor Tyrosine Kinase Ron in Nickel-Induced Acute Lung Injury

2002 ◽  
Vol 26 (1) ◽  
pp. 99-104 ◽  
Author(s):  
Susan A. McDowell ◽  
Ali Mallakin ◽  
Cindy J. Bachurski ◽  
Kenya Toney-Earley ◽  
Daniel R. Prows ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase

scholarly journals THE RON RECEPTOR TYROSINE KINASE REGULATES ACUTE LUNG INJURY AND SUPPRESSES NUCLEAR FACTOR ??B ACTIVATION

Shock ◽  
2007 ◽  
Vol 27 (3) ◽  
pp. 274-280 ◽  
Author(s):  
Alex B. Lentsch ◽  
Peterson Pathrose ◽  
Sarah Kader ◽  
Satoshi Kuboki ◽  
Margaret H. Collins ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Nuclear Factor ◽  
Factor B ◽  
Ron Receptor

scholarly journals Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury

2014 ◽  
Vol 307 (6) ◽  
pp. L435-L448 ◽  
Author(s):  
Agnieszka Krupa ◽  
Marek Fol ◽  
Moshiur Rahman ◽  
Karen Y. Stokes ◽  
Jon M. Florence ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Tyrosine Kinase ◽  
Immune Complex ◽  
Distress Syndrome ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase ◽  
Neutrophil Survival

Previous observations made by our laboratory indicate that Bruton's tyrosine kinase (Btk) may play an important role in the pathophysiology of local inflammation in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). We have shown that there is cross talk between FcγRIIa and TLR4 in alveolar neutrophils from patients with ALI/ARDS and that Btk mediates the molecular cooperation between these two receptors. To study the function of Btk in vivo we have developed a unique two-hit model of ALI: LPS/immune complex (IC)-induced ALI. Furthermore, we conjugated F(ab)2 fragments of anti-neutrophil antibodies (Ly6G1A8) with specific siRNA for Btk to silence Btk specifically in alveolar neutrophils. It should be stressed that we are the first group to perform noninvasive transfections of neutrophils, both in vitro and in vivo. Importantly, our present findings indicate that silencing Btk in alveolar neutrophils has a dramatic protective effect in mice with LPS/IC-induced ALI, and that Btk regulates neutrophil survival and clearance of apoptotic neutrophils in this model. In conclusion, we put forward a hypothesis that Btk-targeted neutrophil specific therapy is a valid goal of research geared toward restoring homeostasis in lungs of patients with ALI/ARDS.

Src protein tyrosine kinase family and acute inflammatory responses

2006 ◽  
Vol 291 (2) ◽  
pp. L129-L141 ◽  
Author(s):  
Daisuke Okutani ◽  
Monika Lodyga ◽  
Bing Han ◽  
Mingyao Liu
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Tyrosine Kinase ◽  
Reperfusion Injury ◽  
Protein Tyrosine Kinase ◽  
Inflammatory Responses ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Critical Role ◽  
Protein Tyrosine

Acute inflammatory responses are one of the major underlying mechanisms for tissue damage of multiple diseases, such as ischemia-reperfusion injury, sepsis, and acute lung injury. By use of cellular and molecular approaches and transgenic animals, Src protein tyrosine kinase (PTK) family members have been identified to be essential for the recruitment and activation of monocytes, macrophages, neutrophils, and other immune cells. Src PTKs also play a critical role in the regulation of vascular permeability and inflammatory responses in tissue cells. Importantly, animal studies have demonstrated that small chemical inhibitors for Src PTKs attenuate tissue injury and improve survival from a variety of pathological conditions related to acute inflammatory responses. Further investigation may lead to the clinical application of these inhibitors as drugs for ischemia-reperfusion injury (such as stroke and myocardial infarction), sepsis, acute lung injury, and multiple organ dysfunction syndrome.

Src tyrosine kinase inhibition prevents pulmonary ischemia–reperfusion-induced acute lung injury

2012 ◽  
Vol 38 (5) ◽  
pp. 894-905 ◽  
Author(s):  
Takeshi Oyaizu ◽  
Shan-Yu Fung ◽  
Atsushi Shiozaki ◽  
Zehong Guan ◽  
Qiao Zhang ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Tyrosine Kinase ◽  
Ischemia Reperfusion ◽  
Kinase Inhibition ◽  
Src Tyrosine Kinase ◽  
Tyrosine Kinase Inhibition ◽  
Pulmonary Ischemia
Sign in / Sign up

Export Citation Format

Share Document