Characterization Of Human Fetal Airway Smooth Muscle Cells: An In Vitro Model System For The Developing Airway

2011 ◽  
Author(s):  
William R. Hartman ◽  
Michael A. Thompson ◽  
Y S Prakash ◽  
Hitesh Pandya ◽  
Yassine Amrani ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Airway Smooth Muscle ◽  
In Vitro Model ◽  
Model System ◽  
Airway Smooth Muscle Cells ◽  
In Vitro Model System ◽  
Vitro Model

Characterization of an in vitro model system to explore control of tumor invasion of EMT6 and 4THM breast tumors by CD200:CD200R interactions

Breast Cancer ◽  
2018 ◽  
Vol 25 (5) ◽  
pp. 547-559 ◽  
Author(s):  
Reginald M. Gorczynski ◽  
Nuray Erin ◽  
Tahir Maqbool ◽  
Christopher P. Gorczynski ◽  
Laura Y. Gorczynski
Keyword(s):  
Tumor Invasion ◽  
In Vitro Model ◽  
Breast Tumors ◽  
Model System ◽  
In Vitro Model System ◽  
Vitro Model

scholarly journals Exposure of ichnovirus particles to digitonin leads to enhanced infectivity and induces fusion from without in an in vitro model system

2007 ◽  
Vol 88 (11) ◽  
pp. 2977-2984 ◽  
Author(s):  
Don Stoltz ◽  
Renée Lapointe ◽  
Andrea Makkay ◽  
Michel Cusson
Keyword(s):  
Outer Membrane ◽  
In Vitro Model ◽  
Model System ◽  
Host Cells ◽  
Fusion Event ◽  
Susceptible Host ◽  
In Vitro Model System ◽  
Vitro Model

Unlike most viruses, the mature ichnovirus particle possesses two unit membrane envelopes. Following loss of the outer membrane in vivo, nucleocapsids are believed to gain entry into the cytosol via a membrane fusion event involving the inner membrane and the plasma membrane of susceptible host cells; accordingly, experimentally induced damage to the outer membrane might be expected to increase infectivity. Here, in an attempt to develop an in vitro model system for studying ichnovirus infection, we show that digitonin-induced disruption of the virion outer membrane not only increases infectivity, but also uncovers an activity not previously associated with any polydnavirus: fusion from without.

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