Inappropriate Initial Antimicrobial Therapy In Cirrhotic Patients With Septic Shock Is Associated With A Great Increase In Mortality

2011 ◽  
Author(s):  
Yaseen Arabi ◽  
Nehad Shirawi ◽  
Ziad Memish ◽  
Abdullah Al-Shimemeri ◽  
Sergio Zanotti ◽  
...  
Keyword(s):  
Septic Shock ◽  
Antimicrobial Therapy ◽  
Great Increase ◽  
Initial Antimicrobial Therapy ◽  
Cirrhotic Patients

scholarly journals Adequate initial antimicrobial therapy as the factor assessing treatment efficacy in human septic shock

Critical Care ◽  
2015 ◽  
Vol 19 (Suppl 1) ◽  
pp. P105
Author(s):  
P Szturz ◽  
P Folwarczny ◽  
J Švancara ◽  
R Kula ◽  
P Ševèík
Keyword(s):  
Septic Shock ◽  
Antimicrobial Therapy ◽  
Treatment Efficacy ◽  
Human Septic Shock ◽  
Initial Antimicrobial Therapy

Septic Shock

1992 ◽  
Vol 7 (2) ◽  
pp. 90-100 ◽  
Author(s):  
Margaret M. Parker ◽  
Mitchell P. Fink
Keyword(s):  
Septic Shock ◽  
Supportive Care ◽  
Antimicrobial Therapy ◽  
Clinical Manifestations ◽  
Sepsis Syndrome ◽  
Adjunctive Treatment ◽  
Cardiovascular Changes ◽  
The Past ◽  
Sepsis And Septic Shock ◽  
Very High

The incidence of sepsis and septic shock has been increasing dramatically over the past 10 years. Despite advances in antimicrobial therapy, the mortality of septic shock remains very high. We review the clinical manifestations of sepsis and septic shock and describe the cardiovascular manifestations. Pathophysiology of the cardiovascular changes is discussed, and mediators believed to be involved in the pathogenesis are reviewed. Management of septic shock is also discussed, including antimicrobial therapy, supportive care, and adjunctive treatment aimed at affecting the mediators involved in producing the sepsis syndrome.

Postoperative Vasodilatory Shock

2020 ◽  
pp. 333-342
Author(s):  
Fiona Roberts ◽  
Alan Gaffney
Keyword(s):  
Septic Shock ◽  
Cardiac Output ◽  
Fluid Resuscitation ◽  
Antimicrobial Therapy ◽  
Pulse Pressure ◽  
Vasodilatory Shock ◽  
First Line ◽  
Treatment Interventions ◽  
Common Cause ◽  
Early Fluid

This chapter discusses vasodilatory shock. The hallmark of vasodilatory shock is hypotension with normal or increased cardiac output. The hyperdynamic circulatory state of vasodilatory shock results in a tachycardia and an increased pulse pressure. Radiological and biochemical investigations can assist with determining the diagnosis of shock. The causes of vasodilatory shock are diverse; they include sepsis, surgical insult, anaphylaxis, and others such as trauma, burns, and pancreatitis. However, sepsis is by far the most common cause of vasodilatory shock. The pathophysiology of vasodilatory shock is also complex and multifactorial. Although still not fully understood, it is widely accepted that it includes activation of several intrinsic vasodilatory pathways and a vascular hyporesponsiveness to vasopressors. Early fluid resuscitation and appropriate antimicrobial therapy are the most crucial treatment interventions in septic shock. Meanwhile, noradrenaline is the first-line vasopressor of choice in septic shock.

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