Altered Polymorphonuclear Leukocyte Apoptosis In Individuals With Alpha-1 Antitrypsin Deficiency Is Associated With Endoplasmic Reticulum Stress And IL-6 Expression

2012 ◽  
Author(s):  
Killian Hurley ◽  
David A. Bergin ◽  
Oliver J. McElvaney ◽  
Emer P. Reeves ◽  
Noel G. McElvaney
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Polymorphonuclear Leukocyte ◽  
Leukocyte Apoptosis ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin

scholarly journals Oxidative Stress and Endoplasmic Reticulum Stress in Rare Respiratory Diseases

2021 ◽  
Vol 10 (6) ◽  
pp. 1268
Author(s):  
María Magallón ◽  
Ana Esther Carrión ◽  
Lucía Bañuls ◽  
Daniel Pellicer ◽  
Silvia Castillo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cystic Fibrosis ◽  
Endoplasmic Reticulum ◽  
Primary Ciliary Dyskinesia ◽  
Respiratory Diseases ◽  
Therapeutic Agents ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin ◽  
Ciliary Dyskinesia

Several studies have shown that some rare respiratory diseases, such as alpha-1 antitrypsin deficiency (AATD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), and primary ciliary dyskinesia (PCD) present oxidative stress (OS) and endoplasmic reticulum (ER) stress. Their involvement in these pathologies and the use of antioxidants as therapeutic agents to minimize the effects of OS are discussed in this review.

scholarly journals Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha 1 ‐antitrypsin deficiency

Hepatology ◽  
2013 ◽  
Vol 57 (5) ◽  
pp. 2049-2060 ◽  
Author(s):  
Adriana Ordóñez ◽  
Erik L. Snapp ◽  
Lu Tan ◽  
Elena Miranda ◽  
Stefan J. Marciniak ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cellular Stress ◽  
Protein Mobility ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin
Sign in / Sign up

Export Citation Format

Share Document