scholarly journals Oxidative Stress and Endoplasmic Reticulum Stress in Rare Respiratory Diseases

2021 ◽  
Vol 10 (6) ◽  
pp. 1268
Author(s):  
María Magallón ◽  
Ana Esther Carrión ◽  
Lucía Bañuls ◽  
Daniel Pellicer ◽  
Silvia Castillo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cystic Fibrosis ◽  
Endoplasmic Reticulum ◽  
Primary Ciliary Dyskinesia ◽  
Respiratory Diseases ◽  
Therapeutic Agents ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin ◽  
Ciliary Dyskinesia

Several studies have shown that some rare respiratory diseases, such as alpha-1 antitrypsin deficiency (AATD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), and primary ciliary dyskinesia (PCD) present oxidative stress (OS) and endoplasmic reticulum (ER) stress. Their involvement in these pathologies and the use of antioxidants as therapeutic agents to minimize the effects of OS are discussed in this review.

Screening for respiratory disease

2018 ◽  
Author(s):  
Abdul Nasimudeen
Keyword(s):  
Cystic Fibrosis ◽  
Respiratory Diseases ◽  
Sleep Apnoea ◽  
Healthy Population ◽  
Obstructive Sleep ◽  
Screening Strategies ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin

Routine screening for respiratory diseases is currently not available to the general healthy population, with the exception of screening for cystic fibrosis. This chapter discusses the screening strategies in place for cystic fibrosis, TB, and other conditions, such as COPD, lung cancer, alpha-1 antitrypsin deficiency, pulmonary hypertension, pulmonary arteriovenous malformation, and obstructive sleep apnoea, for which screening can be applied. While screening has the potential to improve quality of life through early diagnosis and management, it is not an easy process and cannot offer a guarantee of protection.

Oxidative Stress and Polymorphism of Xenobiotic-Metabolizing Enzymes in Two Patients with Severe Alpha-1-Antitrypsin Deficiency

2016 ◽  
Vol 54 (5) ◽  
pp. 746-752 ◽  
Author(s):  
Aleksandra Topic ◽  
Ljudmila Nagorni-Obradovic ◽  
Djordje Francuski ◽  
Mila Ljujic ◽  
Zivka Malic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin

scholarly journals Current opportunities for the treatment of respiratory diseases in paediatric practice

2018 ◽  
pp. 132-136 ◽  
Author(s):  
V. N. Drozdov ◽  
S. Yu. Serebrova ◽  
O. А. Vorobyeva ◽  
A. K. Starodubtsev ◽  
O. V. Dobrovolsky
Keyword(s):  
Cystic Fibrosis ◽  
Primary Ciliary Dyskinesia ◽  
Bacterial Pneumonia ◽  
Respiratory Diseases ◽  
Clinical Effect ◽  
Fixed Dose ◽  
Low Doses ◽  
Dose Combination ◽  
Paediatric Practice ◽  
Ciliary Dyskinesia

Immediacy of the problem of combination therapy of respiratory diseases in paediatric practice is caused by their multifactorial pathogenesis in children and the need to achieve a high clinical effect in the use of drugs at relatively low doses and with minimum risks of serious adverse effects and drug interactions. The fixed-dose combination of salbutamol, bromhexine and guaifenesin produced in the form of tablets and syrup fully meets these requirements, which makes it possible to use it in children and adults with acute, chronic infectious (ARVI, bacterial pneumonia, respiratory tuberculosis, etc.) and non-infectious (bronchial asthma, pulmonary cystic fibrosis, primary ciliary dyskinesia, etc.) diseases.

scholarly journals Oxidative stress contributes to liver damage in a murine model of alpha-1-antitrypsin deficiency

2012 ◽  
Vol 237 (10) ◽  
pp. 1163-1172 ◽  
Author(s):  
Nancy Y Marcus ◽  
Keith Blomenkamp ◽  
Muneeb Ahmad ◽  
Jeffrey H Teckman
Keyword(s):  
Oxidative Stress ◽  
Liver Damage ◽  
Murine Model ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin
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