Monocyte IL-10 Production during Respiratory Syncytial Virus Bronchiolitis Is Associated with Recurrent Wheezing in a One-Year Follow-up Study

2000 ◽  
Vol 161 (5) ◽  
pp. 1518-1523 ◽  
Author(s):  
LOUIS BONT ◽  
COBI J. HEIJNEN ◽  
ANNEMIEKE KAVELAARS ◽  
WIM M. C. van AALDEREN ◽  
FRANK BRUS ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Recurrent Wheezing ◽  
Respiratory Syncytial Virus Bronchiolitis ◽  
Follow Up Study ◽  
Syncytial Virus ◽  
One Year

scholarly journals Macrophage Receptor With Collagenous Structure Polymorphism and Recurrent Respiratory Infections and Wheezing During Infancy: A 5-Years Follow-Up Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Francesco Savino ◽  
Francesco Pellegrino ◽  
Valentina Daprà ◽  
Cristina Calvi ◽  
Carla Alliaudi ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Respiratory Syncytial Virus Infection ◽  
Respiratory Infections ◽  
Significant Risk ◽  
Recurrent Infection ◽  
Recurrent Wheezing ◽  
Follow Up Study ◽  
Syncytial Virus

Background: Recurrent wheezing is a common clinical manifestation in childhood, and respiratory syncytial virus infection is a well-known risk factor. However, the genetic background favoring the development of recurrent wheezing is not fully understood. A possible role of macrophage receptor with collagenous gene (MARCO) polymorphism has been recently proposed.Objective: To investigate a correlation between MARCO rs1318645 polymorphisms and susceptibility to recurrent wheezing during childhood.Methods: We prospectively recruited 116 infants, of which 58 with respiratory syncytial virus bronchiolitis and 58 controls hospitalized at Regina Margherita Children's Hospital, Turin, Italy, between November 2014 and April 2015. All subjects were investigated for MARCO rs1318645 polymorphisms in the first period of life. Genotyping of rs1318645 was carried out by TaqMan mismatch amplification mutation assay real-time polymerase chain reaction procedure. Subjects were then enrolled in a 5-year follow-up study to monitor the occurrence of wheezing and respiratory infections.Results: The analysis of MARCO rs1318645 of allelic frequencies shows an increasingly significant risk to develop recurrent infection (p = 0.00065) and recurrent wheezing (p = 0.000084) with a wild-type C allele compared with a G allele. No correlation was found between wheezing and past respiratory syncytial virus infection (p = 0.057) and for a history of atopy in the family (p = 0.859).Conclusion: Our finding showed that subjects with C allelic MARCO rs1318645 polymorphism are at higher risk for recurrent infection and wheezing episodes during the first 5 years of life. Future studies of genetic associations should also consider other types of polymorphisms.

Viral Load in Infants Hospitalized for Respiratory Syncytial Virus Bronchiolitis Correlates with Recurrent Wheezing at Thirty-Six-Month Follow-Up

2015 ◽  
Vol 34 (10) ◽  
pp. 1131-1132 ◽  
Author(s):  
Raffaella Nenna ◽  
Marianna Ferrara ◽  
Ambra Nicolai ◽  
Alessandra Pierangeli ◽  
Carolina Scagnolari ◽  
...  
Keyword(s):  
Viral Load ◽  
Respiratory Syncytial Virus ◽  
Recurrent Wheezing ◽  
Respiratory Syncytial Virus Bronchiolitis ◽  
Syncytial Virus

scholarly journals Recurrent Wheezing and Asthma After Respiratory Syncytial Virus Bronchiolitis

2021 ◽  
Vol 9 ◽  
Author(s):  
Yunlian Zhou ◽  
Lin Tong ◽  
Mengyao Li ◽  
Yingshuo Wang ◽  
Lanxin Li ◽  
...  
Keyword(s):  
Risk Factor ◽  
Respiratory Syncytial Virus ◽  
Birth Weight ◽  
Cesarean Section ◽  
Age Of Onset ◽  
Recurrent Wheezing ◽  
Female Ratio ◽  
The Mean ◽  
Syncytial Virus

Background: Respiratory syncytial virus (RSV) is the most common pathogen of acute bronchiolitis in children, which sometimes triggers the development of recurrent wheezing and increases the risk of childhood asthma.Methods: We enrolled 425 children who were diagnosed with RSV-infected bronchiolitis at the department of pulmonology, Children's Hospital Zhejiang University School of Medicine in 2011. Long-term follow-up was performed to explore the consequence of bronchiolitis on subsequent recurrent wheezing and asthma.Results: Of 425 patients, 266 cases completed the entire follow-up, the mean age of onset was 4.9 (3.3) months, and the male-to-female ratio was 2.5. The mean birth weight of all patients was 3.22 (0.63) kg, and the number of patients who had a history of cesarean section was 148. According to the outcome of follow-up, 36 were in the recurrent wheezing (RW) group, 65 were in the asthma (AS) group, and the remaining 165 were in the completely recovered (CR) group. The age of onset was older and the birth weights were higher in the AS group than those in the CR group (P < 0.05). And the higher proportion of cesarean sections was higher in the RW group than that in the CR group (P < 0.05). Furthermore, we found a remarkable increasing of serum IgE in the AS groups than that in the CR group (P < 0.01). Multiple logistic regression analysis showed that the cesarean section was the risk factor for the development of recurrent wheezing and the higher birth weight was the risk factor for the development of asthma.Conclusion: RSV bronchiolitis might increase the incidence of recurrent wheezing and asthma. Allergic constitution was an important prerequisite for the occurrence of asthma, and related risk factor such as cesarean section can only increase recurrent wheezing to a certain extent within a certain period of time. And we also find higher birth weight and older onset age for those who develop asthma, which should be verified in the future.

scholarly journals Bronchiolitis, respiratory syncytial virus, and recurrent wheezing: what is the relationship?

2003 ◽  
Vol 58 (1) ◽  
pp. 39-48 ◽  
Author(s):  
Claudia de Brito Fonseca ◽  
Sandra Grisi
Keyword(s):  
Respiratory Syncytial Virus ◽  
Significant Proportion ◽  
Airway Hyperreactivity ◽  
Recurrent Wheezing ◽  
Airway Mucosa ◽  
Syncytial Virus ◽  
The Individual ◽  
The Relationship ◽  
Irritant Receptors

Various follow-up studies of children hospitalized with bronchiolitis caused by respiratory syncytial virus have demonstrated that a significant proportion of infants (50%) have recurrent wheezing during childhood. Nevertheless, the relationship between these two entities, if any, has not been established. In order to explain this observation, several hypotheses have been proposed. The first suggests that some children could have an individual predisposition to bronchiolitis caused by respiratory syncytial virus and recurrent wheezing. The virus could be a marker of this condition, and the individual predisposition could in turn be related to an individual hypersensitivity to common allergens (atopy), airway hyperreactivity, or to some disorder related to pulmonary anatomy or physiology that was present before the acute episode of bronchiolitis. Another hypothesis proposes that respiratory syncytial virus could be directly responsible for recurrent wheezing. During an episode of bronchiolitis, the damage in the airway mucosa caused by the vital inflammatory response to infection contributes to sensitivity to other allergens or exposes irritant receptors, resulting in recurrent wheezing. For this review, we analyzed the studies that discuss these hypotheses with the purpose of clarifying the mechanisms for the important issue of recurrent wheezing in childhood.

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