The role of central respiratory muscle fatigue in determining endurance time (ET) of steady-state ergometry, ventilation (VE), and breathing pattern during exhaustive submaximal exercise is not known. Six normal subjects exercised on a cycle ergometer to exhaustion at 72–82% of maximal power output on three occasions. During the second test, inspiratory muscle load was reduced (approximately 50% of baseline load) for all but the last 3 min of exercise. ET was determined, and VE, tidal volume (VT), respiratory rate (f), and sense of breathing effort (Borg scale) were assessed at different points during the assisted exercise and compared with the values obtained at the same time in identical tests without assist, carried out before and after the assisted test (different days). Borg scale rating was less and there was a nonsignificant trend for VT and VE to be higher and for f to be lower when the assist was in place than at the same time during the unassisted runs. In the last 3 min of exercise, when the respiratory load was comparable (assist removed) but ventilatory work history was different, there were no significant differences in sense of respiratory effort, VE, VT, or f between the experimental and control tests, and ET was also similar. We conclude that central respiratory muscle fatigue plays no role in determining ET, sense of respiratory effort, or breathing pattern in normal subjects during exhaustive submaximal exercise.
