scholarly journals Comparative Chromatographic and Spectrophotometric Methods for Quantitative Estimation of Paracetamol in Analgesic Tablet Dosage Forms

2017 ◽  
Vol 5 (6) ◽  
pp. 98
Author(s):  
Adams Udoji Itodo
Keyword(s):  
Quantitative Estimation ◽  
Dosage Forms ◽  
Spectrophotometric Methods ◽  
Tablet Dosage

scholarly journals Uv Spectrophotometric Methods for Determination of Sofosbuvir in Pure Form and Pharmaceutical Dosage Forms in Presence of Its Alkaline Degradate

2020 ◽  
pp. 12-25
Author(s):  
Zeinab Adel Nasr ◽  
Noha S. Said ◽  
Sawsan A. Abdel-Razeq
Keyword(s):  
Good Accuracy ◽  
Dosage Forms ◽  
Difference Spectra ◽  
Pharmaceutical Dosage Forms ◽  
Spectrophotometric Methods ◽  
Good Linearity ◽  
Ratio Difference ◽  
Accuracy And Precision ◽  
Tablet Dosage

Aims: Two spectrophotometric methods were developed and validated for the determination of sofosbuvir in presence of its alkaline degradate. Study Design: Ratio difference and ratio derivative methods were assisted for determination of sofosbuvir in presence of its alkaline degradate, laboratory-prepared mixtures and in tablet dosage forms. Place and Duration of Study: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy (Girls), Al - Azhar University, between December 2019 and January 2020. Methodology: Two analytical methods were achieved and validated for the quantitative determination of Sofosbuvir in presence of its alkaline degradate. The first method was ratio difference (RD) method, where the UV absorption spectra of different concentrations of sofosbuvir were divided by the spectrum of a certain concentration (15 µg mL-1) as a devisor of its alkaline degradate to get the ratio difference spectra. Afterwards, the peak amplitudes difference between 253.7 and 243.5 nm were measured. The second method was the ratio derivative (1DR) method, where the first derivative of the ratio spectra (1DR) was obtained and its amplitude was measured at 247 and 268 nm. Good linearity was obtained over the concentration range of 3-15 µg mL-1 for the proposed methods. The proposed procedures were adopted for the selective determination of intact Sofosbuvir in presence of up to 80% of its degradation product. Sofosbuvir was exposed to different conditions as alkaline, acidic and oxidative degradation. Results: The proposed methods were developed and validated with good linearity range of 3-15 µg mL-1 for both methods, and also with good accuracy and precision. And the obtained results were statistically compared to those obtained by the reported method. Conclusion: Sofosbuvir was successfully determined by the proposed ratio difference and ratio derivative methods in bulk powder, laboratory prepared mixtures and tablet dosage form with good accuracy and precision. The methods were validated according to ICH guidelines. The results obtained were compared with those of the reported method and were found to be in good agreement.

scholarly journals Development and Validation of Spectrophotometric Methods for the Estimation of Mesalamine in Tablet Dosage Forms

2010 ◽  
Vol 2 (3) ◽  
pp. 284-288 ◽  
Author(s):  
K.M. Patel ◽  
C.N. Patel ◽  
B. Panigrahi ◽  
A.S. Parikh ◽  
H.N. Patel
Keyword(s):  
Dosage Forms ◽  
Spectrophotometric Methods ◽  
Development And Validation ◽  
Tablet Dosage

Fully Validated Simultaneous Determination of Bisoprolol Fumarate and Hydrochlorothiazide in Their Dosage Forms Using Different Voltammetric, Chromatographic, and Spectrophotometric Analytical Methods

2013 ◽  
Vol 96 (1) ◽  
pp. 42-51 ◽  
Author(s):  
Burcin Bozal ◽  
Mehmet Gumustas ◽  
Burcu Dogan -Topal ◽  
Bengi Uslu ◽  
Sibel A Ozkan
Keyword(s):  
Simultaneous Determination ◽  
Square Wave Voltammetry ◽  
Internal Standard ◽  
Differential Pulse ◽  
Dosage Forms ◽  
Spectrophotometric Methods ◽  
Rp Hplc ◽  
Wave Voltammetry ◽  
Tablet Dosage

Abstract Voltammetric, chromatographic, and spectrophotometric methods were developed for the simultaneous determination of bisoprolol fumarate (BIS) and hydrochlorothiazide (HCZ). Differential pulse and square wave voltammetry techniques were used to analyze BIS and HCZ simultaneously by measuring at about 1400 and 1100 mV, respectively. RP-HPLC was the second method for simultaneous analysis of the compounds. The mixture of BIS, HCZ, and moxifloxacin as an internal standard was separated on an RP Zorbax Eclipse XDB-C18 column (150 × 4.6 mm, id, 5 μm particle size) using acetonitrile–15 mM phosphate (25 + 75, v/v) mobile phase at a 1.0 mL/min flow rate. The third method was based on first derivative of the ratio-spectra method obtained from the measurements of the amplitudes at 246 and 257 nm for BIS and HCZ, respectively. All the proposed methods were effectively applied for the simultaneous determination of BIS and HCZ in tablet dosage forms without any time-consuming extraction, sample preparation, or derivatization procedures.

scholarly journals Simple and Inexpensive Methods Development for Determination of Venlafaxine Hydrochloride from Its Solid Dosage Forms by Visible Spectrophotometry

2012 ◽  
Vol 9 (3) ◽  
pp. 1645-1654 ◽  
Author(s):  
K. Raghubabu ◽  
L. Shanti Swarup ◽  
B. Kalyanaramu ◽  
M. N. Rao ◽  
C. Ramdas
Keyword(s):  
Absorption Maximum ◽  
Reference Method ◽  
Cost Effective ◽  
Dosage Forms ◽  
Calibration Graph ◽  
Spectrophotometric Methods ◽  
Methods Development ◽  
Venlafaxine Hydrochloride ◽  
Tablet Dosage

Two simple, sensitive and cost effective visible spectrophotometric methods (M1 and M2) have been developed for the determination of venlafaxine hydrochloride from bulk and tablet dosage forms. The method M1 is based on the formation of green colored coordination complex by the drug with cobalt thiocyanate which is quantitatively extractable into nitro benzene with an absorption maximum of 626.4 nm. The method M2 involves internal salt formation of aconitic anhydride, dehydration product of citric acid [CIA] with acetic anhydride [Ac2O] to form colored chromogen with an absorption maximum of 561.2 nm. The calibration graph is linear over the concentration range of 10-50 µg/mL and 8-24 µg/mL for method M1 and M2 respectively. The proposed methods are applied to commercial available tablets and the results are statistically compared with those obtained by the reference method and validated by recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of the venlafaxine hydrochloride in the presence of other ingredients that are usually present in dosage forms.

scholarly journals ANALYSIS ANALYSIS OF CAFFEINE IN TABLET DOSAGE FORM WITH SPECTROPHOTOMETRIC AND IODOMETRIC BACK TITRATION METHODS

2019 ◽  
Vol 4 (6) ◽  
pp. 271-280
Author(s):  
Edy Agustian Yazid
Keyword(s):  
Spectrophotometric Method ◽  
Active Ingredient ◽  
Dosage Form ◽  
Dosage Forms ◽  
Titration Method ◽  
Simple Apparatus ◽  
Spectrophotometric Methods ◽  
True Value ◽  
Back Titration ◽  
Tablet Dosage

Caffeine (1, 3, 5-trimethylxanthine) is an active ingredient that is often added to analgesics drugs to teat headaches or reduce pain. This study aims to quantitatively analyze caffeine levels in tablet dosage forms by spectrophotometric methods and iodometric back titration. In the spectrophotometric method the measurement of caffeine levels was carried out using a maximum wavelength of 272 nm.The results of caffeine levels were found for bodrex drugs (50.87 ± 0.195 mg/tab), extra panadol (64.92 ± 0.579 mg/tab), saridon (51.38 ± 0.273 mg/tab) and paramex (46.78 ± 0.072 mg/tab). The purity percentage of caffeine was found in the range between 93.57-102.76%. While the iodometric back titration method was obtained for bodrex (48.04 ± 0.889 mg/tab), extra panadol (64.45 ± 0.697 mg/tab), saridon (43.38 ± 0.756 mg/tab) and paramex (42.36 ± 0.889 mg/tab) with a purity range of 84.73-99.15%. The average caffeine content of the two method extant suitability close to the true value as stated on the label. The results of the spectrophotometric method are more accurate, while the titrimetry method is still good to use because it is cheaper and only requires simple apparatus and common chemicals.

scholarly journals Simple and sensitive spectrophotometric methods for the analysis of mesalamine in bulk and tablet dosage forms

Química Nova ◽  
2011 ◽  
Vol 34 (6) ◽  
pp. 1068-1073 ◽  
Author(s):  
Bala Sekaran Chandra ◽  
Siva Santhosh Bhogela ◽  
Manjusha Shaik ◽  
Chaitanya Sravanthi Vadlamudi ◽  
Meghana Chappa ◽  
...  
Keyword(s):  
Dosage Forms ◽  
Spectrophotometric Methods ◽  
Tablet Dosage
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