Study of the Preparation of Calcium Phosphate Cement and Polymethyl Methacrylate with Bone Morphogenetic Protein-2 for Biological Composite Bone Cement

2017 ◽  
Vol 7 (8) ◽  
pp. 696-707 ◽  
Author(s):  
Zhao-Lan Wei ◽  
Jun Yang ◽  
Fu-Ming Li ◽  
Wei-Qiu Peng ◽  
Dong Xie ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Bone Morphogenetic Protein ◽  
Polymethyl Methacrylate ◽  
Calcium Phosphate Cement ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein ◽  
Composite Bone

Effects of strontium-modified calcium phosphate cement combined with bone morphogenetic protein-2 on osteoporotic bone defects healing in rats

2018 ◽  
Vol 33 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Zhoushan Tao ◽  
Wanshu Zhou ◽  
Yunyun Jiang ◽  
Xingjin Wu ◽  
Zhujun Xu ◽  
...  
Keyword(s):  
Single Dose ◽  
Calcium Phosphate ◽  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Calcium Phosphate Cement ◽  
Bone Morphogenetic Protein 2 ◽  
Local Administration ◽  
Ovx Rats ◽  
Local Bone ◽  
Morphogenetic Protein

The objective of the present study was to incorporate strontium into calcium phosphate cement combined with a lower single-dose local administration of bone morphogenetic protein-2 to enhance its in vivo biodegradation and bone tissue growth. After the creation of a rodent critical-sized femoral metaphyseal bone defect, strontium-modified calcium phosphate cement was prepared by mixing sieved granules of calcium phosphate cement and 5% SrCO3 for medical use, and then strontium-modified calcium phosphate cement with dripped bone morphogenetic protein-2 solution (5 µg) was implanted into the defect of OVX rats until death at eight weeks. The defected area in distal femurs of rats was harvested for evaluation by histology, micro-CT, and biomechanics. The results of our study show that a lower single-dose local administration of bone morphogenetic protein-2 combined local usage of strontium-modified calcium phosphate cement can increase the healing of defects in OVX rats. Furthermore, treatments with single-dose local administration of bone morphogenetic protein-2 and strontium-modified calcium phosphate cement showed a stronger effect on accelerating the local bone formation than calcium phosphate cement and strontium-modified calcium phosphate cement used alone. The results from our study demonstrate that combination of a lower single-dose local administration of bone morphogenetic protein-2 and strontium-modified calcium phosphate cement had an additive effect on local bone formation in osteoporosis rats.

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