Cellular Response to Gene Expression Profiles of Different Hepatitis C Virus Core Proteins in the Huh-7 Cell Line with Microarray Analysis

2005 ◽  
Vol 5 (8) ◽  
pp. 1230-1235 ◽  
Author(s):  
Jun Dou ◽  
Pengbo Liu ◽  
Xinjian Zhang
Keyword(s):  
Gene Expression ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cell Line ◽  
Microarray Analysis ◽  
Cellular Response ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Virus Core ◽  
Core Proteins

scholarly journals Differentially regulated gene expression associated with hepatitis C virus clearance

2013 ◽  
Vol 94 (3) ◽  
pp. 534-542 ◽  
Author(s):  
Carolyn Z. Grimes ◽  
Lu-Yu Hwang ◽  
Peng Wei ◽  
Dimpy P. Shah ◽  
Kelly A. Volcik ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Drug Users ◽  
Expression Profiles ◽  
Treatment Strategies ◽  
Gene Expression Profiles ◽  
Spontaneous Resolution ◽  
Virus Clearance ◽  
Regulated Gene Expression

Human chronic hepatitis C virus (HCV) infections pose a significant public health threat, necessitating the development of novel treatments and vaccines. HCV infections range from spontaneous resolution to end-stage liver disease. Approximately 10–30 % of HCV infections undergo spontaneous resolution independent of treatment by yet-to-be-defined mechanisms. These individuals test positive for anti-HCV antibodies in the absence of detectable viral serum RNA. To identify genes associated with HCV clearance, this study compared gene expression profiles between current drug users chronically infected with HCV and drug users who cleared their HCV infection. This analysis identified 91 differentially regulated (up- or downregulated by twofold or more) genes potentially associated with HCV clearance. The majority of genes identified were associated with immune function, with the remaining genes categorized either as cancer related or ‘other’. Identification of factors and pathways that may influence virus clearance will be essential to the development of novel treatment strategies.

scholarly journals Gene-expression profiles of a hepatitis B small surface antigen-secreting cell line reveal upregulation of lymphoid enhancer-binding factor 1

2007 ◽  
Vol 88 (11) ◽  
pp. 2966-2976 ◽  
Author(s):  
Xiaochen Tian ◽  
Chao Zhao ◽  
Jun Ren ◽  
Zhang-Mei Ma ◽  
You-Hua Xie ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatitis B ◽  
Cell Line ◽  
Surface Antigen ◽  
Wnt Pathway ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Stable Cell Line ◽  
Core Proteins ◽  
Binding Factor

The genome of hepatitis B virus (HBV) consists of four open reading frames, encoding the envelope proteins (Pre-S/S), the core proteins (Pre-C/C), the polymerase (P) and the transactivating X protein (X). In the sera of HBV-infected patients, hepatitis B surface antigen (HBsAg) particles without the viral genome can outnumber virions by more than 1000-fold. To analyse the interactions between HBsAg and host cells, global gene-expression profiles of a small HBsAg (SHBs)-secreting stable cell line (HepG2-S-G2) and its counterpart control cell line (HepG2-Neo-F4) were compared. Marked upregulation of lymphoid enhancer-binding factor 1 (LEF-1), a transcription factor in the Wnt pathway, was found in SHBs-expressing cells and was confirmed by interference experiments with small interfering RNA. However, compared with the control cells, HepG2-S-G2 did not show higher proliferative competence in culture or increased tumorigenesis in nude mice. A possible mechanism to explain the discrepancy between the upregulation of LEF-1 and the lack of increased tumorigenesis is SHBs expression resulting in altered expression and distribution of LEF-1 protein in cell compartments and upregulation of LEF-1 isoforms that could suppress, rather than enhance, the Wnt pathway.

scholarly journals Gene Expression Profiles of HeLa Cells Impacted by Hepatitis C Virus Non-structural Protein NS4B

BMB Reports ◽  
2005 ◽  
Vol 38 (2) ◽  
pp. 151-160 ◽  
Author(s):  
Yi Zheng ◽  
Lin-Bai Ye ◽  
Jing Liu ◽  
Wei Jing ◽  
Khalid A. Timani ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hela Cells ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Structural Protein

Intrahepatic gene expression profiles and alpha-smooth muscle actin patterns in hepatitis C virus induced fibrosis

Hepatology ◽  
2005 ◽  
Vol 42 (2) ◽  
pp. 273-281 ◽  
Author(s):  
Daryl T.-Y. Lau ◽  
Bruce A. Luxon ◽  
Shu-Yuan Xiao ◽  
Michael R. Beard ◽  
Stanley M. Lemon
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Expression Profiles ◽  
Smooth Muscle Actin ◽  
Gene Expression Profiles ◽  
Muscle Actin ◽  
Alpha Smooth Muscle Actin
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