Specific Gene-Expression Profiles of Noncancerous Liver Tissue Predict the Risk for Multicentric Occurrence of Hepatocellular Carcinoma in Hepatitis C Virus–Positive Patients

2006 ◽  
Vol 13 (7) ◽  
pp. 947-954 ◽  
Author(s):  
Masahiro Okamoto ◽  
Tohru Utsunomiya ◽  
Shigeki Wakiyama ◽  
Masaji Hashimoto ◽  
Kengo Fukuzawa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Tissue ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Specific Gene ◽  
Multicentric Occurrence ◽  
Noncancerous Liver Tissue

scholarly journals Non-Coding RNAs and Hepatitis C Virus-Induced Hepatocellular Carcinoma

Viruses ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 591 ◽  
Author(s):  
Marie-Laure Plissonnier ◽  
Katharina Herzog ◽  
Massimo Levrero ◽  
Mirjam Zeisel
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Early Detection ◽  
Expression Profiles ◽  
Clinical Perspective ◽  
Aberrant Expression ◽  
Key Players ◽  
Non Coding Rnas

Hepatitis C virus (HCV) infection is a worldwide health problem and is one of the main causes of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). Despite recent improvements, effective treatments for HCC are still missing and new tools for early detection are needed. Non-coding RNAs (ncRNAs) have emerged as important regulators of gene expression and key players in human carcinogenesis, including HCC. Aberrant expression of ncRNAs is associated with HCC metastasis, invasion, dissemination, and recurrence. This review will focus on the recent advances in ncRNA expression profiles, their dysregulation in HCV-related HCC, and the clinical perspective of ncRNA signatures for the early detection of HCC.

scholarly journals Differentially regulated gene expression associated with hepatitis C virus clearance

2013 ◽  
Vol 94 (3) ◽  
pp. 534-542 ◽  
Author(s):  
Carolyn Z. Grimes ◽  
Lu-Yu Hwang ◽  
Peng Wei ◽  
Dimpy P. Shah ◽  
Kelly A. Volcik ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Drug Users ◽  
Expression Profiles ◽  
Treatment Strategies ◽  
Gene Expression Profiles ◽  
Spontaneous Resolution ◽  
Virus Clearance ◽  
Regulated Gene Expression

Human chronic hepatitis C virus (HCV) infections pose a significant public health threat, necessitating the development of novel treatments and vaccines. HCV infections range from spontaneous resolution to end-stage liver disease. Approximately 10–30 % of HCV infections undergo spontaneous resolution independent of treatment by yet-to-be-defined mechanisms. These individuals test positive for anti-HCV antibodies in the absence of detectable viral serum RNA. To identify genes associated with HCV clearance, this study compared gene expression profiles between current drug users chronically infected with HCV and drug users who cleared their HCV infection. This analysis identified 91 differentially regulated (up- or downregulated by twofold or more) genes potentially associated with HCV clearance. The majority of genes identified were associated with immune function, with the remaining genes categorized either as cancer related or ‘other’. Identification of factors and pathways that may influence virus clearance will be essential to the development of novel treatment strategies.

scholarly journals Gene Expression Profiles of HeLa Cells Impacted by Hepatitis C Virus Non-structural Protein NS4B

BMB Reports ◽  
2005 ◽  
Vol 38 (2) ◽  
pp. 151-160 ◽  
Author(s):  
Yi Zheng ◽  
Lin-Bai Ye ◽  
Jing Liu ◽  
Wei Jing ◽  
Khalid A. Timani ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hela Cells ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Structural Protein

scholarly journals Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma

2010 ◽  
Vol 9 (1) ◽  
pp. 74 ◽  
Author(s):  
Masato Tsuchiya ◽  
Joel S Parker ◽  
Hiroshi Kono ◽  
Masanori Matsuda ◽  
Hideki Fujii ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Tissue ◽  
Recurrence Free Survival ◽  
Free Survival
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