Block Copolymer Nanosystems Encapsulating Magnetic Nanoparticles and Drug

2020 ◽  
Vol 20 (7) ◽  
pp. 3981-3988 ◽  
Author(s):  
E. Vlassi ◽  
A. Papagiannopoulos ◽  
A. Sergides ◽  
S. Pispas
Keyword(s):  
Magnetic Nanoparticles ◽  
Ethylene Oxide ◽  
Diblock Copolymers ◽  
Serum Proteins ◽  
Aqueous Media ◽  
Self Assembling ◽  
Bio Imaging ◽  
Poly Ethylene Oxide ◽  
Amphiphilic Diblock Copolymers ◽  
Poly Ethylene

The goal of this study was to investigate the solution behavior of nanosystems composed of self-assembling amphiphilic diblock copolymers, poly(ethylene oxide-b-phenyl oxazoline) and poly(isoprene-b-ethylene oxide) (PEO-b-PPhOx and PI-b-PEO), with encapsulated iron oxide nanoparticles (γ-Fe2O3). The hybrid nanosystems were tested in aqueous solution, under physiological conditions and in mixtures with serum proteins. Light scattering methods were used to probe changes in size and mass of the formed aggregates in different solution conditions and as a function of storage time. The developed stable hybrid systems with encapsulated magnetic nanoparticles were able to entrap the anti-inflammatory drug, indomethacin. This work demonstrates versatile nanosystems with metal oxide characteristics for bio-imaging and the potential for drug delivery in aqueous media.

Photoluminescent polymeric micelles from poly(ethylene oxide)-block-poly(((4-vinylphenyl)ethene-1,1,2-triyl)tribenzene) diblock copolymers

2018 ◽  
Vol 42 (9) ◽  
pp. 7283-7292 ◽  
Author(s):  
Muhammad Adeel ◽  
Sen Xu ◽  
Bingjie Zhao ◽  
Lei Li ◽  
Sixun Zheng
Keyword(s):  
Ethylene Oxide ◽  
Diblock Copolymers ◽  
Polymeric Micelles ◽  
Raft Polymerization ◽  
Aqueous Media ◽  
Self Assembling ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

We report the synthesis of poly(ethylene oxide)-block-poly(((4-vinylphenyl)ethene-1,1,2-triyl)tribenzene) diblock copolymers via RAFT polymerization. The diblock copolymers were capable of self-assembling into photoluminescent micelles in aqueous media.

Synthesis, characterization and association behavior of linear-dendritic amphiphilic diblock copolymers based on poly(ethylene oxide) and a dendron derived from 2,2′-bis(hydroxymethyl)propionic acid

2015 ◽  
Vol 6 (12) ◽  
pp. 2274-2282 ◽  
Author(s):  
Weiwei Zhang ◽  
Weiwei Jiang ◽  
Delong Zhang ◽  
Guangyue Bai ◽  
Pengxiao Lou ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Oxide ◽  
Propionic Acid ◽  
Diblock Copolymers ◽  
Association Behavior ◽  
Poly Ethylene Oxide ◽  
Amphiphilic Diblock Copolymers ◽  
Poly Ethylene

Two new amphiphilic linear-dendritic block copolymers have been synthesized and characterized. And their association behaviors have also been studied.

Self-Assembling Properties of Well-Defined Poly(ethylene oxide)-b-poly(ethyl acrylate) Diblock Copolymers

2009 ◽  
Vol 42 (12) ◽  
pp. 4262-4272 ◽  
Author(s):  
Sandie Piogé ◽  
Laurent Fontaine ◽  
Cédric Gaillard ◽  
Erwan Nicol ◽  
Sagrario Pascual
Keyword(s):  
Ethylene Oxide ◽  
Diblock Copolymers ◽  
Ethyl Acrylate ◽  
Self Assembling ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Synthesis and self-association in aqueous media of poly(ethylene oxide)/poly(ethyl glycidyl carbamate) amphiphilic block copolymers

Polymer ◽  
2006 ◽  
Vol 47 (14) ◽  
pp. 4905-4915 ◽  
Author(s):  
Philip Dimitrov ◽  
Alicja Utrata-Wesołek ◽  
Stanislav Rangelov ◽  
Wojciech Wałach ◽  
Barbara Trzebicka ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Oxide ◽  
Aqueous Media ◽  
Amphiphilic Block Copolymers ◽  
Poly Ethylene Oxide ◽  
Self Association ◽  
Poly Ethylene ◽  
Glycidyl Carbamate

Composition and properties of complexes between anionic liposomes and diblock copolymers with cationic and poly(ethylene oxide) blocks

2017 ◽  
Vol 66 (11) ◽  
pp. 1669-1674 ◽  
Author(s):  
Oleg V Ivashkov ◽  
Andrey V Sybachin ◽  
Anna A Efimova ◽  
Viktor N Orlov ◽  
Dmitry V Pergushov ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Diblock Copolymers ◽  
Anionic Liposomes ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene
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