Synthesis, characterization and association behavior of linear-dendritic amphiphilic diblock copolymers based on poly(ethylene oxide) and a dendron derived from 2,2′-bis(hydroxymethyl)propionic acid

2015 ◽  
Vol 6 (12) ◽  
pp. 2274-2282 ◽  
Author(s):  
Weiwei Zhang ◽  
Weiwei Jiang ◽  
Delong Zhang ◽  
Guangyue Bai ◽  
Pengxiao Lou ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Oxide ◽  
Propionic Acid ◽  
Diblock Copolymers ◽  
Association Behavior ◽  
Poly Ethylene Oxide ◽  
Amphiphilic Diblock Copolymers ◽  
Poly Ethylene

Two new amphiphilic linear-dendritic block copolymers have been synthesized and characterized. And their association behaviors have also been studied.

scholarly journals BEHAVIOR OF ACID HYDROLYSIS IN BLOCK COPOLYMERS COMPRISING POLYACRYLAMIDE AND POLY(ETHYLENE OXIDE)

2018 ◽  
pp. 60-63
Author(s):  
L. Kunitskaya ◽  
T. Zheltonozhskaya
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Ethylene Oxide ◽  
Acid Hydrolysis ◽  
Diblock Copolymers ◽  
Successful Implementation ◽  
Intracellular Space ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Hydrolysis Of

Polymeric micelles self-assembled from amphiphilic block copolymers have been intensively investigated as nano-carrier systems for tumor-targeted drug delivery. Diblock copolymers PEO-b-PAAm (DBC) and thriblock copolymers PAAm-b-PEO-b-PAAm (TBC) contained biocompatible chemically complementary polyacrylamide and poly(ethylene oxide) formed micellar structures in aqueous solutions which have hydrophobic complex “core” formed by the hydrogen-bonded PEO/PAAm chains and hydrophilic “corona” of the surplus segments of PAAm blocks. The ability of DBCs and TBCs to bind the anticancer drug doxorubicin was established. This opened the new prospects for using such copolymers as nanocontainers for toxic and poorly soluble drugs. Successful implementation of DBC and TBC micelles for drug delivery requires the presence a special vectors, particularly galactose, in the micellar “corona”. Such vectors can recognize corresponding receptors on a cellular surface, interact with them, and penetrate into the intracellular space by the endocytosis pathway. In order to introduce the galactose vectors into DBC or TBC micelles, the corona forming PAA blocks have to contain the corresponding active groups, such as –OH, –COO–, –NH2. Therefore, the methods of DBCs (TBCs) functionalization are particularly important since it allows to input the necessary saccharides and also to expand the applications of micellar nanocarriers to encapsulate and delivery of both the drug substances and genetic materials. In the present work, the polymer-analogous conversion of DBCs and TBCs by the acid hydrolysis of PAAm blocks at 50°C was studied. Kinetic investigations of the hydrolysis reaction of DBCs (TBCs) in comparison with pure PAAm were performed by potentiometric titration. It was established that the process of acid hydrolysis of diblock- and thriblock copolymers depends on the blocks length and occurs more intensive in the block copolymers which have longest PEO and PAA chains. The reasons for this phenomenon are discussed. The fact is that hydrolysis of DBCs samples develops efficiently in comparison with TBCs ones attributed to the steric obstacles which appears in TBCs micelles because of their more complicated structure.

Block Copolymer Nanosystems Encapsulating Magnetic Nanoparticles and Drug

2020 ◽  
Vol 20 (7) ◽  
pp. 3981-3988 ◽  
Author(s):  
E. Vlassi ◽  
A. Papagiannopoulos ◽  
A. Sergides ◽  
S. Pispas
Keyword(s):  
Magnetic Nanoparticles ◽  
Ethylene Oxide ◽  
Diblock Copolymers ◽  
Serum Proteins ◽  
Aqueous Media ◽  
Self Assembling ◽  
Bio Imaging ◽  
Poly Ethylene Oxide ◽  
Amphiphilic Diblock Copolymers ◽  
Poly Ethylene

The goal of this study was to investigate the solution behavior of nanosystems composed of self-assembling amphiphilic diblock copolymers, poly(ethylene oxide-b-phenyl oxazoline) and poly(isoprene-b-ethylene oxide) (PEO-b-PPhOx and PI-b-PEO), with encapsulated iron oxide nanoparticles (γ-Fe2O3). The hybrid nanosystems were tested in aqueous solution, under physiological conditions and in mixtures with serum proteins. Light scattering methods were used to probe changes in size and mass of the formed aggregates in different solution conditions and as a function of storage time. The developed stable hybrid systems with encapsulated magnetic nanoparticles were able to entrap the anti-inflammatory drug, indomethacin. This work demonstrates versatile nanosystems with metal oxide characteristics for bio-imaging and the potential for drug delivery in aqueous media.

Novel poly(ethylene oxide monomethyl ether)-b-poly(ε-caprolactone) diblock copolymers containing a pH-acid labile ketal group as a block linkage

2014 ◽  
Vol 5 (12) ◽  
pp. 3884-3893 ◽  
Author(s):  
S. Petrova ◽  
E. Jäger ◽  
R. Konefał ◽  
A. Jäger ◽  
C. G. Venturini ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Oxide ◽  
Diblock Copolymers ◽  
Degradation Products ◽  
Monomethyl Ether ◽  
Amphiphilic Block Copolymers ◽  
Physiological Conditions ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Acid Labile

Acidic physiological conditions trigger degradation of amphiphilic block copolymers containing a ketal group as a block linkage into biocompatible degradation products.

Synthesis of new amphiphilic diblock copolymers containing poly(ethylene oxide) and poly(?-olefin)

2002 ◽  
Vol 40 (20) ◽  
pp. 3416-3425 ◽  
Author(s):  
Yingying Lu ◽  
Youliang Hu ◽  
Z. M. Wang ◽  
E. Manias ◽  
T. C. Chung
Keyword(s):  
Ethylene Oxide ◽  
Diblock Copolymers ◽  
Poly Ethylene Oxide ◽  
Amphiphilic Diblock Copolymers ◽  
Poly Ethylene

Aggregates Formed by Poly(Ethylene Oxide)-b-Poly(1H, 1H-Perfluorooctyl Methacrylate) Diblock Copolymers in Solutions

2007 ◽  
Vol 121-123 ◽  
pp. 425-428 ◽  
Author(s):  
Min Young Lee ◽  
Chan Park ◽  
Seong Soo Hong ◽  
Yeong Soon Gal ◽  
Kwon Taek Lim
Keyword(s):  
Block Copolymers ◽  
Ethylene Oxide ◽  
Diblock Copolymers ◽  
Spherical Shape ◽  
Average Diameter ◽  
Continuous Phase ◽  
Cylindrical Domain ◽  
Tem Analysis ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Well-defined block copolymers consisting of a hydrophilic poly (ethylene oxide) (PEO) and lipophobic poly (1H,1H-perfluorooctyl methacrylate) (PFOMA) were synthesized with controlled molecular weight via atom transfer radical polymerization (ATRP). The block copolymers formed stable micelles where PEO is the shell and PFOMA is the core in chloroform. The micellar morphology of PEO5K-b-PFOMA5K was found to be spherical with average diameter of ca. 12 nm, while meandering cylindrical with average diameter of ca. 13 nm was observed for PEO5K-b-PFOMA13K by TEM analysis. The self-assembled structures were reorganized to thermodynamically stable morphologies upon annealing above glass transition temperature (Tg). For example, spherical shape of PEO5K-b-PFOMA5K and cylindrical domain of PFOMA block in PEO5K-b-PFOMA5K became ordered cylindrical and continuous phase, respectively.

Synthesis and Self-Association Behavior of Biodegradable Amphiphilic Poly[bis(ethyl glycinat-N-yl)phosphazene]− Poly(ethylene oxide) Block Copolymers

2002 ◽  
Vol 3 (6) ◽  
pp. 1364-1369 ◽  
Author(s):  
Youngkyu Chang ◽  
Jared D. Bender ◽  
Mwita V. B. Phelps ◽  
Harry R. Allcock
Keyword(s):  
Block Copolymers ◽  
Ethylene Oxide ◽  
Association Behavior ◽  
Poly Ethylene Oxide ◽  
Self Association ◽  
Poly Ethylene

Cleavage of polystyrene-b -poly(ethylene oxide) block copolymers with a trithiocarbonate linkage in solutions

2010 ◽  
Vol 48 (17) ◽  
pp. 3834-3840 ◽  
Author(s):  
Min Cao ◽  
Jian-Qi Wang ◽  
Peng-Cheng Chen ◽  
Jun-Ting Xu ◽  
Zhi-Qiang Fan
Keyword(s):  
Block Copolymers ◽  
Ethylene Oxide ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Synthesis and properties of semifluorinated block copolymers containing poly(ethylene oxide) and poly(fluorooctyl methacrylates) via atom transfer radical polymerisation

Polymer ◽  
2002 ◽  
Vol 43 (25) ◽  
pp. 7043-7049 ◽  
Author(s):  
Kwon Taek Lim ◽  
Min Young Lee ◽  
Myung Jun Moon ◽  
Gun Dae Lee ◽  
Seong-Soo Hong ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Oxide ◽  
Atom Transfer ◽  
Radical Polymerisation ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene
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