Biomechanics of Calcium Sulfate-Sodium Hyaluronate Composite Bone Graft Materials in Treating Radius Fractures
The composite bone graft materials were made of calcium sulfate (CaSO4) and sodium hyaluronate (SH). The SH was in the form of solution, with a concentration of 850 kDa 0.1% v/w. The two materials were mixed in a ratio of 2 g:1 mL to obtain the first composite bone graft material Ca_Nw. Next, CaSO4 was mixed with SH-derivative (cross-linked SH) in a ratio of 2 g:1 mL to obtain the second composite bone graft material Ca_Cn. The experiment included 80 patients with ulna and radius nonunion, who were divided into 4 groups. The included patients were treated with Ca_Nw bone graft material, Ca_Cn bone graft material, autograft, and allograft. The computed tomography (CT) data, MIMICS software, and PRO/E software were utilized to construct the finite element models of AO-typing C-type distal radius fractures treated by different bone graft materials. The fixed constraints of radial and ulnar full degree of freedom (DOF) were set. The 120 N axial pressure was given on the forearm to compare the stress and fracture displacement. The results showed excellent stress simulation effects on two groups of patients treated by composite bone graft materials than those treated by autograft and allograft (P < 0.05).