scholarly journals Artificial Polymeric Scaffolds as Extracellular Matrix Substitutes for Autologous Conjunctival Goblet Cell Expansion

2016 ◽  
Vol 57 (14) ◽  
pp. 6134 ◽  
Author(s):  
Min He ◽  
Thomas Storr-Paulsen ◽  
Annie L. Wang ◽  
Chiara E. Ghezzi ◽  
Siran Wang ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Goblet Cell ◽  
Cell Expansion ◽  
Polymeric Scaffolds

scholarly journals Human periosteal-derived cell expansion in a perfusion bioreactor system: proliferation, differentiation and extracellular matrix formation

2014 ◽  
Vol 11 (2) ◽  
pp. 519-530 ◽  
Author(s):  
M. Sonnaert ◽  
I. Papantoniou ◽  
V. Bloemen ◽  
G. Kerckhofs ◽  
F. P. Luyten ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Expansion ◽  
Perfusion Bioreactor ◽  
Bioreactor System

scholarly journals Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury

Hepatology ◽  
2009 ◽  
Vol 49 (5) ◽  
pp. 1625-1635 ◽  
Author(s):  
Noémi K. M. Van Hul ◽  
Jorge Abarca-Quinones ◽  
Christine Sempoux ◽  
Yves Horsmans ◽  
Isabelle A. Leclercq
Keyword(s):  
Extracellular Matrix ◽  
Liver Injury ◽  
Murine Model ◽  
Cell Expansion ◽  
Progenitor Cell ◽  
Chronic Liver ◽  
Chronic Liver Injury ◽  
Matrix Deposition ◽  
Extracellular Matrix Deposition ◽  
Liver Progenitor Cell

scholarly journals Multi-foci laser microfabrication of 3D polymeric scaffolds for stem cell expansion in regenerative medicine

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Tommaso Zandrini ◽  
Oumin Shan ◽  
Valentina Parodi ◽  
Giulio Cerullo ◽  
Manuela T. Raimondi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Expansion ◽  
Stem Cell Expansion ◽  
Laser Microfabrication ◽  
Polymeric Scaffolds

Extracellular matrix-enriched polymeric scaffolds as a substrate for hepatocyte cultures: in vitro and in vivo studies

Biomaterials ◽  
2005 ◽  
Vol 26 (34) ◽  
pp. 7038-7045 ◽  
Author(s):  
B. Zavan ◽  
P. Brun ◽  
V. Vindigni ◽  
A. Amadori ◽  
W. Habeler ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
In Vivo Studies ◽  
Hepatocyte Cultures ◽  
Polymeric Scaffolds

Evaluating the In Vitro and In Vivo Efficacy of Nano-Dimensional Polymeric Scaffolds for Bladder Tissue Replacement Applications

2007 ◽  
Vol 539-543 ◽  
pp. 540-544
Author(s):  
Karen M. Haberstroh ◽  
Megan A. Pattison ◽  
Martin Kaefer ◽  
Thomas J. Webster
Keyword(s):  
Extracellular Matrix ◽  
Bladder Wall ◽  
Extracellular Matrix Proteins ◽  
Matrix Proteins ◽  
Bladder Tissue ◽  
Tissue Replacement ◽  
Polymeric Scaffolds ◽  
Bladder Replacement

Superficial bladder cancer is often treated by removing the cancerous portion of the bladder wall combined with immuno-chemotherapy; in more extreme cases, it is often necessary to remove the entire bladder wall. This diagnosis brings an obvious need for bladder tissue replacement designs with a high degree of efficacy. Since bladder cells are accustomed to interacting with extracellular matrix proteins having dimensions on the nanometer scale, this study aimed to design the next generation of tissue-engineered bladder replacement constructs with nanometer (less than 100 nm) surface features. For this purpose, porous and biodegradable PLGA and PU scaffolds were treated with various concentrations of NaOH or HNO3, respectively, for various periods of time to create nanometer surface roughness. Resulting surface properties were characterized using SEM (to visualize scaffold properties) and BET. Cell experiments conducted on these polymeric scaffolds provided evidence of enhanced bladder smooth muscle cell attachment, growth, and elastin/collagen production (critical extracellular matrix proteins in the bladder tissue regeneration process) as surface feature dimensions were reduced into the nanometer regime. In vivo augmentation surgeries with nano-structured PLGA and PU patches will provide further information regarding total bladder capacity, anastomotic integrity, burst pressure, epithelialization, muscular ingrowth, and neovascularization. In vitro and in vivo proof of material usefulness and technique would provide urologists with a readily accessible graft for bladder tissue replacement applications.

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