Diurnal Control of Sensory Axon Growth and Shedding in the Mouse Cornea

The simple nervous system of the nematode C. elegans consists of 302 neurons with highly reproducible morphologies, suggesting a hard-wired program of axon guidance. Surprisingly, we show here that sensory activity shapes sensory axon morphology in C. elegans. A class of mutants with deformed sensory cilia at their dendrite endings have extra axon branches, suggesting that sensory deprivation disrupts axon outgrowth. Mutations that alter calcium channels or membrane potential cause similar defects. Cell-specific perturbations of sensory activity can cause cell-autonomous changes in axon morphology. Although the sensory axons initially reach their targets in the embryo, the mutations that alter sensory activity cause extra axon growth late in development. Thus, perturbations of activity affect the maintenance of sensory axon morphology after an initial pattern of innervation is established. This system provides a genetically tractable model for identifying molecular mechanisms linking neuronal activity to nervous system structure.

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Sensory Axon Growth Requires Spatiotemporal Integration of CaSR and TrkB Signaling

Journal of Neuroscience ◽

10.1523/jneurosci.0027-19.2019 ◽

2019 ◽

Vol 39 (30) ◽

pp. 5842-5860 ◽

Cited By ~ 1

Author(s):

Ronja Markworth ◽

Youri Adolfs ◽

Vivian Dambeck ◽

Lars M. Steinbeck ◽

Muriel Lizé ◽

...

Keyword(s):

Axon Growth ◽

Sensory Axon ◽

Spatiotemporal Integration

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NGF Enhances Sensory Axon Growth Induced by Laminin but Not by the L1 Cell Adhesion Molecule

Molecular and Cellular Neuroscience ◽

10.1006/mcne.2002.1107 ◽

2002 ◽

Vol 20 (1) ◽

pp. 2-12 ◽

Cited By ~ 33

Author(s):

Rong-Yu Liu ◽

Ralf-Steffen Schmid ◽

William D. Snider ◽

Patricia F. Maness

Keyword(s):

Cell Adhesion ◽

Adhesion Molecule ◽

Cell Adhesion Molecule ◽

Axon Growth ◽

Sensory Axon ◽

L1 Cell Adhesion Molecule

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Inhibition of PTEN activity promotes IB4-positive sensory neuronal axon growth

10.1101/2020.04.02.019042 ◽

2020 ◽

Author(s):

Li-Yu Zhou ◽

Feng Han ◽

Shi-Bin Qi ◽

Jin-Jin Ma ◽

Yan-Xia Ma ◽

...

Keyword(s):

Nervous System ◽

Sensory Neurons ◽

Strong Evidence ◽

Axon Regeneration ◽

Axon Growth ◽

Clinical Problem ◽

Sensory Axon ◽

Nerve Injuries ◽

Critical Process ◽

Common Clinical Problem

AbstractTraumatic nerve injuries have become a common clinical problem, and axon regeneration is a critical process in the successful functional recovery of the injured nervous system. In this study, we found that peripheral axotomy reduce total PTEN expression in adult sensory neurons, however, it did not alter the expression level of PTEN in IB4-positive sensory neurons. Additionally, our results indicate that the artificial inhibition of PTEN markedly promotes adult sensory axon regeneration, including IB4-positive neuronal axon growth. Thus, our results provide strong evidence that PTEN is a prominent repressor of adult sensory axon regeneration, especially in IB4-positive neurons.

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