scholarly journals Olfactory sensory axon growth and branching is influenced by sonic hedgehog

2009 ◽  
Vol 238 (7) ◽  
pp. 1768-1776 ◽  
Author(s):  
Qizhi Gong ◽  
Huaiyang Chen ◽  
Albert I. Farbman
2018 ◽  
Vol 300 ◽  
pp. 247-258 ◽  
Author(s):  
Ioana Goganau ◽  
Beatrice Sandner ◽  
Norbert Weidner ◽  
Karim Fouad ◽  
Armin Blesch

Development ◽  
1999 ◽  
Vol 126 (9) ◽  
pp. 1891-1902 ◽  
Author(s):  
E.L. Peckol ◽  
J.A. Zallen ◽  
J.C. Yarrow ◽  
C.I. Bargmann

The simple nervous system of the nematode C. elegans consists of 302 neurons with highly reproducible morphologies, suggesting a hard-wired program of axon guidance. Surprisingly, we show here that sensory activity shapes sensory axon morphology in C. elegans. A class of mutants with deformed sensory cilia at their dendrite endings have extra axon branches, suggesting that sensory deprivation disrupts axon outgrowth. Mutations that alter calcium channels or membrane potential cause similar defects. Cell-specific perturbations of sensory activity can cause cell-autonomous changes in axon morphology. Although the sensory axons initially reach their targets in the embryo, the mutations that alter sensory activity cause extra axon growth late in development. Thus, perturbations of activity affect the maintenance of sensory axon morphology after an initial pattern of innervation is established. This system provides a genetically tractable model for identifying molecular mechanisms linking neuronal activity to nervous system structure.


2019 ◽  
Vol 39 (30) ◽  
pp. 5842-5860 ◽  
Author(s):  
Ronja Markworth ◽  
Youri Adolfs ◽  
Vivian Dambeck ◽  
Lars M. Steinbeck ◽  
Muriel Lizé ◽  
...  

2002 ◽  
Vol 20 (1) ◽  
pp. 2-12 ◽  
Author(s):  
Rong-Yu Liu ◽  
Ralf-Steffen Schmid ◽  
William D. Snider ◽  
Patricia F. Maness

2020 ◽  
Author(s):  
Li-Yu Zhou ◽  
Feng Han ◽  
Shi-Bin Qi ◽  
Jin-Jin Ma ◽  
Yan-Xia Ma ◽  
...  

AbstractTraumatic nerve injuries have become a common clinical problem, and axon regeneration is a critical process in the successful functional recovery of the injured nervous system. In this study, we found that peripheral axotomy reduce total PTEN expression in adult sensory neurons, however, it did not alter the expression level of PTEN in IB4-positive sensory neurons. Additionally, our results indicate that the artificial inhibition of PTEN markedly promotes adult sensory axon regeneration, including IB4-positive neuronal axon growth. Thus, our results provide strong evidence that PTEN is a prominent repressor of adult sensory axon regeneration, especially in IB4-positive neurons.


eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Keisuke Onishi ◽  
Yimin Zou

Commissural axons switch on responsiveness to Wnt attraction during midline crossing and turn anteriorly only after exiting the floor plate. We report here that Sonic Hedgehog (Shh)-Smoothened signaling downregulates Shisa2, which inhibits the glycosylation and cell surface presentation of Frizzled3 in rodent commissural axon growth cones. Constitutive Shisa2 expression causes randomized turning of post-crossing commissural axons along the anterior–posterior (A–P) axis. Loss of Shisa2 led to precocious anterior turning of commissural axons before or during midline crossing. Post-crossing commissural axon turning is completely randomized along the A–P axis when Wntless, which is essential for Wnt secretion, is conditionally knocked out in the floor plate. This regulatory link between Shh and planar cell polarity (PCP) signaling may also occur in other developmental processes.


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