Erratum in: Stress Signal Regulation by Na/K-ATPase As a New Approach to Promote Physiological Revascularization in a Mouse Model of Ischemic Retinopathy

Abstract Background and Aims gddY mice are an IgA nephropathy (IgAN)-prone mouse model that develops albuminuria by 8 weeks (wks) of age with glomerular IgA, IgG, and C3 deposits and progressive mesangioproliferative glomerulonephritis. A previous study in the ddY mouse model, the more genetically heterogeneous predecessor of gddY mice, using the endothelin type A receptor (ETAR) antagonist FR139317 resulted in amelioration of proteinuria and preservation of kidney function. Treatment of ddY mice with the angiotensin II type 1 receptor (AT1R) blocker valsartan resulted in significant protection from glomerulosclerosis (GS) without a significant prevention in proteinuria. Here we examined the effect of sparsentan (SP), a dual ETAR and AT1R blocker, currently in phase 3 trials for focal segmental glomerulosclerosis and IgAN, on the development of albuminuria and GS in gddY mice. Method gddY mice at 4 wks of age were fed with control (C) chow (n=5) or chow containing 900 ppm (n=10) or 1800 ppm (n=10) SP (approximately 180 and 360 mg/kg/day) for 8 wks. Albuminuria (U-Alb) was assessed at 4, 6, 8, and 12 wks of age and plasma levels of SP were determined at 8 am and 4 pm at wks 6, 8, and 12. Kidney biopsies were taken at the end of the study at 12 wks of age for processing and 30 glomeruli per animal were scored for the percentage of GS. Results gddY mice fed SP in the diet for 8 wks from 4 wks of age demonstrated significantly (*P<0.05) decreased U-Alb compared to mice fed the C diet in a dose-dependent manner (Figure 1). The development of GS in mice fed the diet containing 1800 ppm SP was significantly (*P<0.05) attenuated compared to C diet (Figure 2). Plasma levels of SP taken at 8 am and 4 pm after 8 wks of treatment were (mean±SD) 281±107 and 105±62 ng/ml for 900 ppm SP respectively, and 774±674 and 304±176 ng/ml for 1800 ppm SP, respectively. Weight gain in mice fed SP was not different from mice that received C diet. Conclusion Eight weeks of treatment with SP attenuated increases in albuminuria and GS associated with the development of IgAN in gddY mice. If translated to the clinic, these data support SP as a new approach to the treatment of IgAN.

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Hyperoxia Therapy of Pre-Proliferative Ischemic Retinopathy in a Mouse Model

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.11-7666 ◽

2011 ◽

Vol 52 (9) ◽

pp. 6384 ◽

Cited By ~ 11

Author(s):

Wenbo Zhang ◽

Harumasa Yokota ◽

Zhimin Xu ◽

Subhadra P. Narayanan ◽

Lauren Yancey ◽

...

Keyword(s):

Mouse Model ◽

Ischemic Retinopathy

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Possible Mechanism for Resistance to Alzheimer's Disease (AD) in Mice Suggests a New Approach to Generate a Mouse Model for Sporadic AD and May Explain Familial Resistance to AD in Man

Experimental Neurology ◽

10.1006/exnr.1997.6420 ◽

1997 ◽

Vol 144 (1) ◽

pp. 214-218 ◽

Cited By ~ 3

Author(s):

Vladimir Volloch

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Mouse Model ◽

New Approach

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An apelin receptor antagonist inhibits pathological retinal angiogenesis in a mouse model of ischemic retinopathy

Proceedings for Annual Meeting of The Japanese Pharmacological Society ◽

10.1254/jpssuppl.wcp2018.0_po2-9-9 ◽

2018 ◽

Vol WCP2018 (0) ◽

pp. PO2-9-9

Author(s):

Fumiya Shibagaki ◽

Yuki Ishimaru ◽

Hiroko Konishi ◽

Mayu Suzuki ◽

Yuya Fujii ◽

...

Keyword(s):

Mouse Model ◽

Receptor Antagonist ◽

Ischemic Retinopathy ◽

Retinal Angiogenesis ◽

Apelin Receptor

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NEW APPROACH TO ADDITIONAL LEFT-TURN SECTIONS OF THE TRAFFIC SIGNAL REGULATION

The Russian Automobile and Highway Industry Journal ◽

10.26518/2071-7296-2019-4-432-445 ◽

2019 ◽

Vol 16 (4) ◽

pp. 432-445 ◽

Cited By ~ 2

Author(s):

A. P. Zhigadlo ◽

S. V. Dorokhin ◽

D. V. Likhachev

Keyword(s):

Traffic Flow ◽

Queue Length ◽

Flow Speed ◽

Optimal Choice ◽

New Approach ◽

Left Turn ◽

Forward Flow ◽

Traffic Organization ◽

Signal Regulation ◽

Turn Direction

Introduction. The paper describes methods of using the additional left-turn phase of regulation. The authors view the main foreign and domestic methods used in the specialization of the left turn in a separate phase of regulation. To propose a new approach to the specialization of the left-turn direction in a separate phase of regulation the authors investigate one of the most loaded intersections in Voronezh and determine the main characteristics of the traffic flow. Therefore, the authors suggest new parameters in choosing of the necessary method of traffic organization at controlled intersections.Methods and materials. The paper analyses the main methods, which were conditionally related to two approaches: the accident rate of the site and the characteristics of the traffic flow (speed and intensity of the left-turn flow). The authors explained that the new approach, which took into account such parameters as speed, vehicle delays and queue length, allowed effectively controlling the intersection due to the optimal choice of the necessary traffic organization method and due to the result of changes in the parameters by combining the intensity of the left-turn flow and forward flow.Results. The authors developed the approach to the additional left-turn section introduction at the controlled intersection based on a comparison of the left-turn intensity and forward flow and on the analysis of changes in the main characteristics of the traffic flow (speed, vehicle delays and queue length).Discussion and conclusions. The authors concluded that it is necessary to use the proposed approach at the stage of modeling, design and reorganization of the regulated area on the basis of changes in the main characteristics of the traffic flow.

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