scholarly journals Learning to see again: Perceptual learning of simulated abnormal on- off-cell population responses in sighted individuals

2021 ◽  
Vol 21 (13) ◽  
pp. 10
Author(s):  
Rebecca B. Esquenazi ◽  
Kimberly Meier ◽  
Michael Beyeler ◽  
Geoffrey M. Boynton ◽  
Ione Fine
Keyword(s):  
Perceptual Learning ◽  
Cell Population ◽  
Population Responses

scholarly journals The contribution of age structure to cell population responses to targeted therapeutics

2012 ◽  
Vol 311 ◽  
pp. 19-27 ◽  
Author(s):  
Pierre Gabriel ◽  
Shawn P. Garbett ◽  
Vito Quaranta ◽  
Darren R. Tyson ◽  
Glenn F. Webb
Keyword(s):  
Cell Population ◽  
Age Structure ◽  
Targeted Therapeutics ◽  
Population Responses

scholarly journals Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise

2012 ◽  
Vol 6 (1) ◽  
pp. 109 ◽  
Author(s):  
Marc R Birtwistle ◽  
Jens Rauch ◽  
Anatoly Kiyatkin ◽  
Edita Aksamitiene ◽  
Maciej Dobrzyński ◽  
...  
Keyword(s):  
Protein Expression ◽  
Cell Signaling ◽  
Single Cell ◽  
Cell Population ◽  
Population Responses ◽  
Expression Noise

Ultrastructural Changes in the Mammary Epithelial Cell Population During Neoplastic Development Induced by A Chemical Carcinogen.

1976 ◽  
Vol 34 ◽  
pp. 250-251 ◽  
Author(s):  
J. Russo ◽  
W. Isenberg ◽  
M. Ireland ◽  
I.H. Russo
Keyword(s):  
Mammary Gland ◽  
Cell Population ◽  
Virgin Female ◽  
Histological Change ◽  
Mammary Epithelial ◽  
Female Rats ◽  
Ultrastructural Changes ◽  
Post Inoculation ◽  
Chemical Carcinogen ◽  
Sprague Dawley

The induction of rat mammary carcinoma by the chemical carcinogen DMBA is used as a model for the study of the human disease (1). We previously described the histochemical changes that occur in the mammary gland of DMBA treated animals before the earliest manifested histological change, the intraductal proliferation (IDP), was observed (2). In the present work, we demonstrate that a change in the stable cell population found in the resting mammary gland occurs after carcinogen administration.Fifty-five day old Sprague-Dawley virgin female rats were inoculated intragastrically with 20mg of 7,12-dimethylbenz(a)anthracene (DMBA) in 1ml sesame oil. Non-inoculated, age-matched females were used as controls. Mammary glands from control and inoculated rats were removed weekly from the time of inoculation until 60 days post-inoculation. For electron microscopy, the glands were immersed in Karnovsky's fixative, post-fixed in 1% OsO4, dehydrated, and embedded in an Epon-Araldite mixture. Thick (lμ) sections were stained with 1% toluidine blue and were used for selecting areas for ultrastructural study.

Perceptual Learning of Vocoded Speech With and Without Contralateral Hearing: Implications for Cochlear Implant Rehabilitation

2020 ◽  
pp. 1-10
Author(s):  
Martin Chavant ◽  
Alexis Hervais-Adelman ◽  
Olivier Macherey
Keyword(s):  
Cochlear Implant ◽  
Perceptual Learning ◽  
Speech Signal ◽  
Training Phase ◽  
Monosyllabic Words ◽  
Low Pass ◽  
Contralateral Ear ◽  
Number Of Individuals ◽  
Insight Into ◽  
Vocoded Speech

Purpose An increasing number of individuals with residual or even normal contralateral hearing are being considered for cochlear implantation. It remains unknown whether the presence of contralateral hearing is beneficial or detrimental to their perceptual learning of cochlear implant (CI)–processed speech. The aim of this experiment was to provide a first insight into this question using acoustic simulations of CI processing. Method Sixty normal-hearing listeners took part in an auditory perceptual learning experiment. Each subject was randomly assigned to one of three groups of 20 referred to as NORMAL, LOWPASS, and NOTHING. The experiment consisted of two test phases separated by a training phase. In the test phases, all subjects were tested on recognition of monosyllabic words passed through a six-channel “PSHC” vocoder presented to a single ear. In the training phase, which consisted of listening to a 25-min audio book, all subjects were also presented with the same vocoded speech in one ear but the signal they received in their other ear differed across groups. The NORMAL group was presented with the unprocessed speech signal, the LOWPASS group with a low-pass filtered version of the speech signal, and the NOTHING group with no sound at all. Results The improvement in speech scores following training was significantly smaller for the NORMAL than for the LOWPASS and NOTHING groups. Conclusions This study suggests that the presentation of normal speech in the contralateral ear reduces or slows down perceptual learning of vocoded speech but that an unintelligible low-pass filtered contralateral signal does not have this effect. Potential implications for the rehabilitation of CI patients with partial or full contralateral hearing are discussed.

The Role of Early Perceptual Learning in Reading

2000 ◽  
Author(s):  
Tatjana A. Nazir ◽  
Avital Deutsch ◽  
Jonathan Grainger ◽  
Ram Frost
Keyword(s):  
Perceptual Learning

Pupil Diameter Changes Non-Monotonically With Perceptual Learning

2012 ◽  
Author(s):  
Taylor R. Hayes ◽  
Alexander A. Petrov
Keyword(s):  
Perceptual Learning ◽  
Pupil Diameter
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