scholarly journals Corneal Confocal Microscopy in Type 1 Diabetes Mellitus: A Six-Year Longitudinal Study

2022 ◽  
Vol 11 (1) ◽  
pp. 17
Author(s):  
Stuti L. Misra ◽  
James A. Slater ◽  
Charles N. J. McGhee ◽  
Monika Pradhan ◽  
Geoffrey D. Braatvedt
2021 ◽  
pp. bjophthalmol-2021-319057
Author(s):  
Hoda Gad ◽  
Bara Al-Jarrah ◽  
Saras Saraswathi ◽  
Sara Mohamed ◽  
Alise Kalteniece ◽  
...  

PurposeTo assess whether alterations in stromal keratocyte density are related to loss of corneal nerve fibres in children with type 1 diabetes mellitus (T1DM).MethodsTwenty participants with T1DM and 20 age-matched healthy controls underwent corneal confocal microscopy. Corneal sub-basal nerve morphology and corneal keratocyte density (KD) were quantified.ResultsCorneal nerve fibre density (CNFD) (p<0.001), corneal nerve branch density (p<0.001), corneal nerve fibre length (CNFL) (p<0.001) and inferior whorl length (IWL) (p<0.001) were lower in children with T1DM compared with healthy controls. Anterior (p<0.03) and mid (p=0.03) stromal KDs were lower with no difference in posterior KD (PKD) in children with T1DM compared with controls. Age, duration of diabetes, height, weight and body mass index did not correlate with anterior (AKD), mid (MKD) or PKD. Inverse correlations were found between glycated haemoglobin and PKD (r=−0.539, p=0.026), bilirubin with MKD (r=−0.540, p=0.025) and PKD (r=−0.531, p=0.028) and 25-hydroxycholecalciferol with MKD (r=−0.583, p=0.018). CNFD, CNFL and IWL did not correlate with AKD, MKD or PKD.ConclusionThis study demonstrates a reduction in corneal nerves and anterior and mid stromal KD in children with T1DM, but no correlation between corneal nerve and keratocyte cell loss.


2011 ◽  
Vol 59 (3) ◽  
pp. 563-565 ◽  
Author(s):  
Eelco van Duinkerken ◽  
Augustina M.A. Brands ◽  
Esther van den Berg ◽  
Johanna M.L. Henselmans ◽  
Roel P.L.M. Hoogma ◽  
...  

2018 ◽  
Vol 19 (5) ◽  
pp. 963-971 ◽  
Author(s):  
Ana Laura Fitas ◽  
Catarina Martins ◽  
Luís Miguel Borrego ◽  
Lurdes Lopes ◽  
Anne Jörns ◽  
...  

2002 ◽  
Vol 3 (4) ◽  
pp. 189-193 ◽  
Author(s):  
Shankar Kanumakala ◽  
Preeti Dabadghao ◽  
John B. Carlin ◽  
Suzanna Vidmar ◽  
Fergus J. Cameron

2018 ◽  
Vol 22 ◽  
Author(s):  
Agma Leozina Viana Souza ◽  
Aleida Nazareth Soares ◽  
Tatiane Géa-Horta ◽  
Alexandra Dias Moreira ◽  
Janice Sepúlveda Reis

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