scholarly journals Corneal Confocal Microscopy in Type 1 Diabetes Mellitus: A Six-Year Longitudinal Study

2022 ◽  
Vol 11 (1) ◽  
pp. 17
Author(s):  
Stuti L. Misra ◽  
James A. Slater ◽  
Charles N. J. McGhee ◽  
Monika Pradhan ◽  
Geoffrey D. Braatvedt
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Longitudinal Study ◽  
Confocal Microscopy ◽  
Type 1 Diabetes Mellitus ◽  
Corneal Confocal Microscopy

Corneal confocal microscopy identifies a reduction in corneal keratocyte density and sub-basal nerves in children with type 1 diabetes mellitus

2021 ◽  
pp. bjophthalmol-2021-319057
Author(s):  
Hoda Gad ◽  
Bara Al-Jarrah ◽  
Saras Saraswathi ◽  
Sara Mohamed ◽  
Alise Kalteniece ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Confocal Microscopy ◽  
Type 1 Diabetes Mellitus ◽  
Nerve Fibre ◽  
Healthy Controls ◽  
Corneal Confocal Microscopy ◽  
Corneal Nerve ◽  
Keratocyte Density

PurposeTo assess whether alterations in stromal keratocyte density are related to loss of corneal nerve fibres in children with type 1 diabetes mellitus (T1DM).MethodsTwenty participants with T1DM and 20 age-matched healthy controls underwent corneal confocal microscopy. Corneal sub-basal nerve morphology and corneal keratocyte density (KD) were quantified.ResultsCorneal nerve fibre density (CNFD) (p<0.001), corneal nerve branch density (p<0.001), corneal nerve fibre length (CNFL) (p<0.001) and inferior whorl length (IWL) (p<0.001) were lower in children with T1DM compared with healthy controls. Anterior (p<0.03) and mid (p=0.03) stromal KDs were lower with no difference in posterior KD (PKD) in children with T1DM compared with controls. Age, duration of diabetes, height, weight and body mass index did not correlate with anterior (AKD), mid (MKD) or PKD. Inverse correlations were found between glycated haemoglobin and PKD (r=−0.539, p=0.026), bilirubin with MKD (r=−0.540, p=0.025) and PKD (r=−0.531, p=0.028) and 25-hydroxycholecalciferol with MKD (r=−0.583, p=0.018). CNFD, CNFL and IWL did not correlate with AKD, MKD or PKD.ConclusionThis study demonstrates a reduction in corneal nerves and anterior and mid stromal KD in children with T1DM, but no correlation between corneal nerve and keratocyte cell loss.

COGNITION IN OLDER PATIENTS WITH TYPE 1 DIABETES MELLITUS: A LONGITUDINAL STUDY

2011 ◽  
Vol 59 (3) ◽  
pp. 563-565 ◽  
Author(s):  
Eelco van Duinkerken ◽  
Augustina M.A. Brands ◽  
Esther van den Berg ◽  
Johanna M.L. Henselmans ◽  
Roel P.L.M. Hoogma ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Longitudinal Study ◽  
Type 1 Diabetes Mellitus ◽  
Older Patients

scholarly journals Immune cell and cytokine patterns in children with type 1 diabetes mellitus undergoing a remission phase: A longitudinal study

2018 ◽  
Vol 19 (5) ◽  
pp. 963-971 ◽  
Author(s):  
Ana Laura Fitas ◽  
Catarina Martins ◽  
Luís Miguel Borrego ◽  
Lurdes Lopes ◽  
Anne Jörns ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Longitudinal Study ◽  
Type 1 Diabetes Mellitus ◽  
Immune Cell ◽  
Remission Phase

Linear growth and height outcomes in children with early onset type 1 diabetes mellitus - a 10-yr longitudinal study

2002 ◽  
Vol 3 (4) ◽  
pp. 189-193 ◽  
Author(s):  
Shankar Kanumakala ◽  
Preeti Dabadghao ◽  
John B. Carlin ◽  
Suzanna Vidmar ◽  
Fergus J. Cameron
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Longitudinal Study ◽  
Type 1 Diabetes Mellitus ◽  
Early Onset ◽  
Linear Growth ◽  
Onset Type

scholarly journals PROFILE AND CLINICAL EVOLUTION OF PATIENTS WITH TYPE 1 DIABETES MELLITUS: A LONGITUDINAL STUDY AT A SECONDARY REFERENCE CENTER IN MINAS GERAIS

2018 ◽  
Vol 22 ◽  
Author(s):  
Agma Leozina Viana Souza ◽  
Aleida Nazareth Soares ◽  
Tatiane Géa-Horta ◽  
Alexandra Dias Moreira ◽  
Janice Sepúlveda Reis
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Longitudinal Study ◽  
Type 1 Diabetes Mellitus ◽  
Minas Gerais ◽  
Reference Center ◽  
Clinical Evolution
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