scholarly journals KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction

JCI Insight ◽  
2021 ◽  
Author(s):  
Guizhen Zhao ◽  
Ziyi Chang ◽  
Yang Zhao ◽  
Yanhong Guo ◽  
Haocheng Lu ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Endothelial Cell ◽  
Aortic Aneurysm ◽  
Endothelial Cell Dysfunction ◽  
Cell Dysfunction ◽  
Abdominal Aortic

scholarly journals Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II–Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm

Hypertension ◽  
2018 ◽  
Vol 72 (1) ◽  
pp. 128-138 ◽  
Author(s):  
Surawee Chuaiphichai ◽  
Victoria S. Rashbrook ◽  
Ashley B. Hale ◽  
Lucy Trelfa ◽  
Jyoti Patel ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Abdominal Aortic Aneurysm ◽  
Endothelial Cell ◽  
Angiotensin Ii ◽  
Aortic Aneurysm ◽  
Vascular Remodeling ◽  
Abdominal Aortic

Mature endothelial cell therapy stabilizes abdominal aortic aneurysm through paracrine mechanisms and recruitment of local vascular cells

2012 ◽  
Vol 56 (5-6) ◽  
pp. 342
Author(s):  
Grégory Franck ◽  
Jianping Dai ◽  
Stéphanie Michineau ◽  
Saravath Ngo ◽  
Anne-Marie Guinault ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Endothelial Cell ◽  
Aortic Aneurysm ◽  
Cell Therapy ◽  
Vascular Cells ◽  
Mature Endothelial Cell ◽  
Abdominal Aortic

Effect of Intraluminal Thrombus Thickness and Bulge Diameter on the Oxygen Diffusion in Abdominal Aortic Aneurysm

1998 ◽  
Vol 120 (5) ◽  
pp. 579-583 ◽  
Author(s):  
D. A. Vorp ◽  
D. H. J. Wang ◽  
M. W. Webster ◽  
W. J. Federspiel
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Oxygen Diffusion ◽  
Three Dimensional ◽  
Hypoxic Cell ◽  
Intraluminal Thrombus ◽  
Cell Dysfunction ◽  
Abdominal Aortic ◽  
O2 Supply ◽  
Two Parameters

The intraluminal thrombus (ILT) commonly found within abdominal aortic aneurysm (AAA) may serve as a barrier to oxygen diffusion from the lumen to the inner layers of the aortic wall. The purpose of this work was to address this hypothesis and to assess the effects of AAA bulge diameter (dAAA) and ILT thickness (δ) on the oxygen flow. A hypothetical, three-dimensional, axisymmetric model of AAA containing ILT was created for computational analysis. Commercial software was utilized to estimate the volume flow of O2 per cell, which resulted in zero oxygen tension at the AAA wall. Solutions were generated by holding one of the two parameters fixed while varying the other. The supply of O2 to the AAA wall increases slightly and linearly with dAAA for a fixed δ. This slight increase is due to the enlarged area through which diffusion of O2 may take place. The supply of O2 was found to decrease quickly with increasing δ for a fixed dAAA due to the increased resistance to O2 transport by the ILT layer. The presence of even a thin, 3 mm ILT layer causes a diminished O2 supply (less than 4 × 10−10 μmol/min/cell). Normally functioning smooth muscle cells require a supply of 21 × 10−10 μmol/min/cell. Thus, our analysis serves to support our hypothesis that the presence of ILT alters the normal pattern of O2 supply to the AAA wall. This may lead to hypoxic cell dysfunction in the AAA wall, which may further lead to wall weakening and increased potential for rupture.

Abstract 15302: Deficiency of Myeloid Membrane-bound Thrombomodulin Attenuates Vascular Inflammation in Abdominal Aortic Aneurysm

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Hua-Lin Wu ◽  
Kuan-Chieh Wang ◽  
Guey-Yueh Shi
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Endothelial Cell ◽  
Aortic Aneurysm ◽  
Vascular Inflammation ◽  
Ros Production ◽  
Wild Type ◽  
Abdominal Aortic ◽  
Membrane Bound ◽  
Deficient Mice ◽  
Endothelial Cell Adhesion

Introduction: Thrombomodulin (TM), a glycoprotein predominantly expressed in endothelial cells, has been well known for its anti-coagulant and anti-inflammatory properties. Paradoxically, we recently found a promoting role of monocytic membrane-bound TM in experimental sepsis. Hypothesis: We assessed the hypothesis that membrane-bound TM may participate in vascular inflammation and the development of abdominal aortic aneurysm (AAA). Methods and Results: Characterization of the CaCl 2 -induced AAA in mice revealed that TM expression was mainly localized in vascular smooth muscle cells (VSMCs) and infiltrating macrophages. To investigate the function of membrane-bound TM in vivo, transgenic mice with myeloid- (LysMcre/TM flox/flox ) and VSMC-specific (SM22-cre tg /TM flox/flox ) TM ablation and their wild type counterparts were generated. In the CaCl 2 -induced AAA model, myeloid TM-deficient mice (n=12) but not VSMC TM-deficient mice (n=8), when compared with their wild-type respective controls (TM flox/flox , SM22-cre tg /TM +/+ ), showed attenuated accumulation of macrophages, reduced production of proinflammatory cytokines and suppressed levels of matrix metalloproteinase-9, thereby preventing progressive aortic dilatation. In vitro TM-deficient macrophages had reduced proinflammatory mediator production, macrophage-endothelial cell adhesion and intracellular oxidative stress (e.g., reactive oxygen species [ROS]) versus TM wild-type macrophages. In addition, deficiency of TM in hyperlipidemic mice (ApoE -/- /LysMcre/TM flox/flox , n=9) conferred protection against angiotensin II-infused AAA, compatible with dramatically diminished aortic ROS production and matrix metalloproteinase activities. Finally, human AAA samples (n=6) showed that TM signals were predominantly localized to infiltrating macrophages, implicating the potential involvement of monocytic membrane-bound TM in human diseases. Conclusion: Membrane-bound TM in macrophages plays a critical role in the development of AAA by enhancing macrophage-endothelial cell adhesion, proinflammatory mediator elaboration and intracellular ROS production.

Current evidence and prospects for medical treatment of abdominal aortic aneurysms

VASA ◽  
2005 ◽  
Vol 34 (4) ◽  
pp. 217-223 ◽  
Author(s):  
Diehm ◽  
Schmidli ◽  
Dai-Do ◽  
Baumgartner
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Medical Treatment ◽  
Endovascular Treatment ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Current Evidence ◽  
Significant Morbidity ◽  
Abdominal Aortic ◽  
Risk Of Rupture

Abdominal aortic aneurysm (AAA) is a potentially fatal condition with risk of rupture increasing as maximum AAA diameter increases. It is agreed upon that open surgical or endovascular treatment is indicated if maximum AAA diameter exceeds 5 to 5.5cm. Continuing aneurysmal degeneration of aortoiliac arteries accounts for significant morbidity, especially in patients undergoing endovascular AAA repair. Purpose of this review is to give an overview of the current evidence of medical treatment of AAA and describe prospects of potential pharmacological approaches towards prevention of aneurysmal degeneration of small AAAs and to highlight possible adjunctive medical treatment approaches after open surgical or endovascular AAA therapy.

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