scholarly journals THE DETERMINATION OF UNEVEN PULMONARY BLOOD FLOW FROM THE ARTERIAL OXYGEN TENSION DURING NITROGEN WASHOUT

1961 ◽  
Vol 40 (9) ◽  
pp. 1727-1734 ◽  
Author(s):  
Theodore N. Finley
Keyword(s):  
Blood Flow ◽  
Oxygen Tension ◽  
Pulmonary Blood Flow ◽  
Arterial Oxygen Tension ◽  
Arterial Oxygen ◽  
Nitrogen Washout

Development of pulmonary vascular response to oxygen

1988 ◽  
Vol 254 (3) ◽  
pp. H542-H546 ◽  
Author(s):  
F. C. Morin ◽  
E. A. Egan ◽  
W. Ferguson ◽  
C. E. Lundgren
Keyword(s):  
Blood Flow ◽  
Right Ventricular ◽  
Oxygen Tension ◽  
Pulmonary Circulation ◽  
Pulmonary Blood Flow ◽  
Arterial Oxygen Tension ◽  
Arterial Oxygen ◽  
Absolute Pressure ◽  
Fetal Lamb ◽  
Near Term

The ability of the pulmonary circulation of the fetal lamb to respond to a rise in oxygen tension was studied from 94 to 146 days of gestation. The unanesthetized ewe breathed room air at normal atmospheric pressure, followed by 100% oxygen at three atmospheres absolute pressure in a hyperbaric chamber. In eleven near-term lambs (132 to 146 days of gestation), fetal arterial oxygen tension (PaO2) increased from 25 +/- 1 to 55 +/- 6 Torr (mean +/- SE), which increased the proportion of right ventricular output distributed to the fetal lungs from 8 +/- 1 to 59 +/- 5%. In five very immature lambs (94 to 101 days of gestation), fetal PaO2 increased from 27 +/- 1 to 174 +/- 70 Torr, but the proportion of right ventricular output distributed to the lung did not change, 8 +/- 1 to 9 +/- 1%. In five of the near-term lambs, pulmonary blood flow was measured. It increased from 34 +/- 3 to 298 +/- 35 ml.kg fetal wt-1.min-1, an 8.8-fold increase. We conclude that the pulmonary circulation of the fetal lamb does not respond to an increase in oxygen tension before 101 days of gestation; however, near term an increase in oxygen tension alone can induce the entire increase in pulmonary blood flow that normally occurs after the onset of breathing at birth.

scholarly journals Bidirectional Ductal Shunting and Preductal to Postductal Oxygenation Gradient in Persistent Pulmonary Hypertension of the Newborn

Children ◽  
2020 ◽  
Vol 7 (9) ◽  
pp. 137
Author(s):  
Amy Lesneski ◽  
Morgan Hardie ◽  
William Ferrier ◽  
Satyan Lakshminrusimha ◽  
Payam Vali
Keyword(s):  
Blood Flow ◽  
Pulmonary Hypertension ◽  
Pulmonary Blood Flow ◽  
Ductus Arteriosus ◽  
Arterial Oxygen Tension ◽  
Persistent Pulmonary Hypertension ◽  
Arterial Oxygen ◽  
Meconium Aspiration ◽  
Arterial Blood Gas ◽  
Arterial Blood

Background: The aim was to evaluate the relationship between the direction of the patent ductus arteriosus (PDA) shunt and the pre- and postductal gradient for arterial blood gas (ABG) parameters in a lamb model of meconium aspiration syndrome (MAS) with persistent pulmonary hypertension of the newborn (PPHN). Methods: PPHN was induced by intermittent umbilical cord occlusion and the aspiration of meconium through the tracheal tube. After delivery, 13 lambs were ventilated and simultaneous 129 pairs of pre- and postductal ABG were drawn (right carotid and umbilical artery, respectively) while recording the PDA and the carotid and pulmonary blood flow. Results: Meconium aspiration resulted in hypoxemia. The bidirectional ductal shunt had a lower postductal partial arterial oxygen tension ([PaO2] with lower PaO2/FiO2 ratio—97 ± 36 vs. 130 ± 65 mmHg) and left pulmonary flow (81 ± 52 vs. 133 ± 82 mL/kg/min). However, 56% of the samples with a bidirectional shunt had a pre- and postductal saturation gradient of < 3%. Conclusions: The presence of a bidirectional ductal shunt is associated with hypoxemia and low pulmonary blood flow. The absence of a pre- and postductal saturation difference is frequently observed with bidirectional right-to-left shunting through the PDA, and does not exclude a diagnosis of PPHN in this model.

scholarly journals Effects of high arterial oxygen tension on function, blood flow distribution, and metabolism in ischemic myocardium.

Circulation ◽  
1992 ◽  
Vol 85 (2) ◽  
pp. 828-838 ◽  
Author(s):  
B A Cason ◽  
J A Wisneski ◽  
R A Neese ◽  
W C Stanley ◽  
R F Hickey ◽  
...  
Keyword(s):  
Blood Flow ◽  
Oxygen Tension ◽  
Arterial Oxygen Tension ◽  
Flow Distribution ◽  
Ischemic Myocardium ◽  
Arterial Oxygen ◽  
Blood Flow Distribution

Prediction of changing cerebral blood flow by use of the conjunctival oxygen tension/arterial oxygen tension index

1989 ◽  
Vol 17 (12) ◽  
pp. 1328-1332 ◽  
Author(s):  
WILLIAM F. RUTHERFORD ◽  
EDWARD A. PANACEK ◽  
J. KEYEN GRIFFITH ◽  
JEFFREY A. GREEN ◽  
MARK MUNGER ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Oxygen Tension ◽  
Arterial Oxygen Tension ◽  
Arterial Oxygen ◽  
Tension Index ◽  
Conjunctival Oxygen Tension

scholarly journals Deoxygenation Reduces Sickle Cell Blood Flow at Arterial Oxygen Tension

2016 ◽  
Vol 110 (12) ◽  
pp. 2751-2758 ◽  
Author(s):  
Xinran Lu ◽  
David K. Wood ◽  
John M. Higgins
Keyword(s):  
Blood Flow ◽  
Oxygen Tension ◽  
Sickle Cell ◽  
Arterial Oxygen Tension ◽  
Arterial Oxygen

Achieving optimal pulmonary blood flow in the first-stage of palliation in early infancy for complex cardiac defects with hypoplastic left ventricles

1995 ◽  
Vol 5 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Tetsuya Kitagawa ◽  
Itsuo Katoh ◽  
Yoshiaki Fukumura ◽  
Masanori Yoshizumi ◽  
Yutaka Masuda ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pulmonary Blood Flow ◽  
Arterial Oxygen Tension ◽  
Postoperative Mortality ◽  
Arterial Oxygen ◽  
Optimal Size ◽  
Mean Airway Pressure ◽  
Rigid Model ◽  
Pulmonary Arterial ◽  
Left Heart Syndrome

AbstractThe aim of the study was to determine the optimal size and technique for construction of the systemic-to-pulmonary arterial shunt which will provide suitable pulmonary blood flow in first-stage Norwood palliation for hypoplastic left heart syndrome in neonates. Our clinical experience suggested that an arterial oxygen tension of about 30 mm Hg immediately after cardiopulmonary bypass, with the patients being ventilated at the lowest possible mean airway pressure with an FiO2of 1.0, provided a suitable pulmonary-to-systemic flow ratio. We also aimed to clarify the characteristics of pulmonary blood flow in accordance with the size of the shunt and the change in the pulmonary vascular resistance in a simplified rigid model of the Norwood procedure. A hole of2.0 mm diameter proved adequate to provide a suitable pulmonary blood flow of 200−300 mlx002F;min in the presence of a pressure gradient of 20−40 mm Hg between the systemic and pulmonary circulations in neonates weighing 3 kg. A short central shunt with a prosthesis of4 mm in diameter produced an excessive flow of pulmonary blood. Our data suggest that using a smaller shunt than that commonly used is necessary to decrease the early and intermediate postoperative mortality. A prosthesis of 3.0 or 3.5 mm in diameter arising from the brachiocephalic artery would be acceptable and can be recommended for first-stage Norwood palliation in small infants, especially in view of the operative difficulties encountered in taking down the shunt at the time of subsequent operations.

TcPO2 values in limb ischemia: Effects of blood flow and arterial oxygen tension

1986 ◽  
Vol 40 (5) ◽  
pp. 482-487 ◽  
Author(s):  
Hans H. Moosa ◽  
Michel S. Makaroun ◽  
Andrew B. Peitzman ◽  
David L. Steed ◽  
Marshall W. Webster
Keyword(s):  
Blood Flow ◽  
Oxygen Tension ◽  
Arterial Oxygen Tension ◽  
Limb Ischemia ◽  
Arterial Oxygen
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