scholarly journals Extracellular traps released by antimicrobial TH17 cells contribute to host defense

Author(s):  
George W. Agak ◽  
Alice Mouton ◽  
Rosane Teles ◽  
Thomas A. Weston ◽  
Marco Morselli ◽  
...  
Cells ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 2130
Author(s):  
Shrikant R. Mulay ◽  
Hans-Joachim Anders

Neutrophils are first responders of antimicrobial host defense and sterile inflammation, and therefore, play important roles during health and disease [...]


2013 ◽  
Vol 7 (2) ◽  
pp. 138-143 ◽  
Author(s):  
André Gladiator ◽  
Kerstin Trautwein-Weidner ◽  
Eva Bär ◽  
Salomé LeibundGut-Landmann
Keyword(s):  

Author(s):  
Hanna K de Jong ◽  
Gavin CKW Koh ◽  
Ahmed Achouiti ◽  
Anne J van der Meer ◽  
Ingrid Bulder ◽  
...  

2016 ◽  
Vol 24 (8) ◽  
pp. 1139-1153 ◽  
Author(s):  
Nardhy Gomez-Lopez ◽  
Roberto Romero ◽  
Yi Xu ◽  
Derek Miller ◽  
Ronald Unkel ◽  
...  

2019 ◽  
Vol 12 (7) ◽  
pp. a037028 ◽  
Author(s):  
Sabrina Sofia Burgener ◽  
Kate Schroder

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Hsing-Chuan Tsai ◽  
Sharlene Velichko ◽  
Li-Yin Hung ◽  
Reen Wu

The significance of Th17 cells and interleukin- (IL-)17A signaling in host defense and disease development has been demonstrated in various infection and autoimmune models. Numerous studies have indicated that Th17 cells and its signature cytokine IL-17A are critical to the airway’s immune response against various bacteria and fungal infection. Cytokines such as IL-23, which are involved in Th17 differentiation, play a critical role in controllingKlebsiella pneumonia(K. pneumonia) infection. IL-17A acts on nonimmune cells in infected tissues to strengthen innate immunity by inducing the expression of antimicrobial proteins, cytokines, and chemokines. Mice deficient in IL-17 receptor (IL-17R) expression are susceptible to infection by various pathogens. In this review, we summarize the recent advances in unraveling the mechanism behind Th17 cell differentiation, IL-17A/IL-17R signaling, and also the importance of IL-17A in pulmonary infection.


2007 ◽  
Vol 19 (6) ◽  
pp. 377-382 ◽  
Author(s):  
Shean J. Aujla ◽  
Patricia J. Dubin ◽  
Jay K. Kolls
Keyword(s):  

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