scholarly journals Effect of Metabotropic Glutamate Receptor 3 Genotype onN-Acetylaspartate Measures in the Dorsolateral Prefrontal Cortex

2006 ◽  
Vol 163 (4) ◽  
pp. 740-742 ◽  
Author(s):  
Stefano Marenco ◽  
Sonya U. Steele ◽  
Michael F. Egan ◽  
Terry E. Goldberg ◽  
Richard E. Straub ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Glutamate Receptor ◽  
Dorsolateral Prefrontal Cortex ◽  
Metabotropic Glutamate Receptor ◽  
Metabotropic Glutamate ◽  
Metabotropic Glutamate Receptor 3 ◽  
Dorsolateral Prefrontal

scholarly journals Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction

2015 ◽  
Vol 112 (4) ◽  
pp. 1196-1201 ◽  
Author(s):  
Adam G. Walker ◽  
Cody J. Wenthur ◽  
Zixiu Xiang ◽  
Jerri M. Rook ◽  
Kyle A. Emmitte ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Fear Extinction ◽  
Long Term Depression ◽  
Metabotropic Glutamate ◽  
Metabotropic Glutamate Receptor 3

Clinical studies have revealed that genetic variations in metabotropic glutamate receptor 3 (mGlu3) affect performance on cognitive tasks dependent upon the prefrontal cortex (PFC) and may be linked to psychiatric conditions such as schizophrenia, bipolar disorder, and addiction. We have performed a series of studies aimed at understanding how mGlu3 influences PFC function and cognitive behaviors. In the present study, we found that activation of mGlu3 can induce long-term depression in the mouse medial PFC (mPFC) in vitro. Furthermore, in vivo administration of a selective mGlu3 negative allosteric modulator impaired learning in the mPFC-dependent fear extinction task. The results of these studies implicate mGlu3 as a major regulator of PFC function and cognition. Additionally, potentiators of mGlu3 may be useful in alleviating prefrontal impairments associated with several CNS disorders.

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