Association of BDNF Val66MET Polymorphism With Parkinson’s Disease and Depression and Anxiety Symptoms

The objective was to investigate if high cadence cycling altered non-motor cognition and depression symptoms in individuals with Parkinson’s disease (PD) and whether exercise responses were influenced by brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. Individuals with idiopathic PD who were ≥50 years old and free of surgical procedures for PD were recruited. Participants were assigned to either a cycling (n = 20) or control (n = 15) group. The cycling group completed three sessions of high cadence cycling on a custom motorized stationary ergometer. The primary outcome was cognition (attention, executive function, and emotion recognition were assessed via WebNeuro® and global cognition via Montreal Cognitive Assessment). Depression symptoms were assessed via Beck Depression Inventory-II. There was a main effect of time for emotional recognition (p = 0.048), but there were no other changes in cognition or depression symptoms. Regardless of intervention or Val66Met polymorphism, high cadence cycling does not alter cognition or depression symptoms after three sessions in one week.

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Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with Parkinson’s disease in a Greek population

Journal of Clinical Neuroscience ◽

10.1016/j.jocn.2011.03.015 ◽

2011 ◽

Vol 18 (12) ◽

pp. 1744-1745 ◽

Cited By ~ 14

Author(s):

Charalambos Karakasis ◽

Kallirhoe Kalinderi ◽

Zoe Katsarou ◽

Liana Fidani ◽

Sevasti Bostantjopoulou

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Greek Population ◽

Val66met Polymorphism ◽

Bdnf Val66met Polymorphism

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Correlation between Serum Renin-Angiotensin System (RAS) Level and Depression and Anxiety Symptoms in Patients with Parkinson's Disease

Saudi Journal of Biological Sciences ◽

10.1016/j.sjbs.2021.02.029 ◽

2021 ◽

Author(s):

ChongChong Zhao ◽

HongBin Cai ◽

Huan Wang ◽

ZhaoMing Ge

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Renin Angiotensin System ◽

Anxiety Symptoms ◽

Depression And Anxiety ◽

Angiotensin System ◽

Renin Angiotensin

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Impact of Depression and Anxiety on Dimensions of Health-Related Quality of Life in Subjects with Parkinson’s Disease Enrolled in an Association of Patients

Brain Sciences ◽

10.3390/brainsci11060771 ◽

2021 ◽

Vol 11 (6) ◽

pp. 771

Author(s):

Fany Chuquilín-Arista ◽

Tania Álvarez-Avellón ◽

Manuel Menéndez-González

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Psychiatric Symptoms ◽

Well Being ◽

Depression And Anxiety ◽

Health Related Quality ◽

Related Quality ◽

Health Related

Parkinson’s disease (PD) is a complex disorder characterized by a wide spectrum of symptoms. Depression and anxiety are common manifestations in PD and may be determinants of health-related quality of life (HRQoL). The objective of this study is to determine the association of depression and anxiety with the dimensions of HRQoL in subjects with PD enrolled in an association of patients. Ninety-five community-based patients with PD diagnosis at different disease stages were studied. HRQoL was assessed using the Parkinson’s Disease Questionnaire (PDQ-39); depression and anxiety were assessed using the Beck Depression Inventory (BDI-II) and the State-Trait Anxiety Inventory (STAI), respectively. Our results showed that depression and anxiety were negatively associated with HRQoL measured by PDSI. Higher motor dysfunction measured by Hoehn and Yahr (H&Y) staging was also associated with worse HRQoL. Depression was the most influential variable in the model. All PDQ-39 dimensions except social support and bodily discomfort were associated with depression. Anxiety was associated with the emotional well-being and bodily discomfort dimensions. These results suggest that physicians should pay attention to the presence of psychiatric symptoms and treat them appropriately.

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