Increased Platelet Distribution Width Is Associated With Severity of Coronary Artery Disease in Patients With Acute Coronary Syndrome

Angiology ◽  
2014 ◽  
Vol 66 (7) ◽  
pp. 638-643 ◽  
Author(s):  
Adem Bekler ◽  
Muhammed Turgut Alper Ozkan ◽  
Erhan Tenekecioglu ◽  
Emine Gazi ◽  
Ali Umit Yener ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Platelet Distribution Width ◽  
Distribution Width ◽  
Coronary Syndrome ◽  
Artery Disease

scholarly journals Serum parameters and severity of coronary artery disease in patients with acute coronary syndrome

2020 ◽  
Vol 6 (1) ◽  
pp. e12-e12
Author(s):  
Fardin Mirbolouk ◽  
Fatemeh Baharvand ◽  
Arsalan Salari ◽  
Maryam Shakiba ◽  
Mani Moayerifar ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Serum Creatinine ◽  
Multinomial Logistic Regression ◽  
White Blood Cells ◽  
Distribution Width ◽  
Serum Parameters ◽  
Coronary Syndrome ◽  
Artery Disease

Introduction: Coronary artery disease (CAD) is one of the most common causes of morbidity and mortality in developed countries. SYNTAX (SX) score is a useful index that scores lesion severity during coronary angiography (CA) and can predict the patient’s outcome. Recent studies have associated a number of serum parameters with SX score, including platelet volume, and platelet-to-lymphocyte ratio (PLR). Objectives: We aimed to study the SX score in association with various serum parameters to find a valuable parameter for prediction of CAD severity. Patients and Methods: This study consisted of 363 patients referred to Heshmat hospital (Rasht) from March 2016 to October 2016 with acute coronary syndrome (ACS). Serum laboratory parameters were measured after 12 hours of fasting. Severity of CAD was evaluated during CA by SX score. The associations were analyzed using multinomial logistic regression model. Results: The mean age of patients was 63.68±11.03 years; since 26.2% of cases had severe, 43% had moderate, and 30.8% had mild CAD. Comparing to mild CAD, the multivariate adjusted model showed higher significant odds of severe CAD for one elevation of platelets (odds ratio [OR] =2.18 (95% CI: 1.35-3.50), white blood cells (WBCs) (OR=1.66, 95% CI: 1.17-2.35) RDW (red cell distribution width), (OR=1.59, 95% CI: 1.08-2.35) and serum creatinine (OR=1.75, 95% CI: 1.16-2.63). Conclusion: Plasma platelets, WBC and RDW and also serum creatinine were all independently correlated with severity of CAD.

scholarly journals Evaluation of platelet indices in patients with acute coronary syndrome and chronic stable angina

2020 ◽  
Vol 8 (11) ◽  
pp. 3886
Author(s):  
Vijay Sai Chowdekar ◽  
Naveen Peddi
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Stable Angina ◽  
Chronic Stable Angina ◽  
Control Group ◽  
Distribution Width ◽  
Platelet Indices ◽  
Coronary Syndrome ◽  
Artery Disease

Background: The objective of the study was to evaluate the levels of platelet indices mean platelet volume (MPV) and platelet distribution width (PDW) in patients with acute coronary syndrome (ACS) and chronic stable angina (CSA) and to study its correlation with the occurrence of disease.Methods: This was a hospital-based, case-control, prospective observational study which included 333 patients who fulfilled inclusion and exclusion criteria. All the patients were divided into three groups after clinical investigations: i) 100 patients in ACS group, ii) 114 patients in CSA group and iii) 119 patients in control group. MPV and PDW levels were estimated in all the patients along with other routine investigations related to coronary artery disease. All the data were analyzed using independent sample t-test, ANOVA and Pearson correlation at 95% level of significance.Results: Troponin levels were significantly higher in ACS group compared to CSA and control group (p<0.0001). Mean MPV levels in ACS (15.57±2.11 fL) and CSA (11.27±1.7 fL) groups were significantly higher (p<0.0001) compared with controls (10.48±1.49 fL). A significant elevation in MPV levels was observed in patients with a greater number of diseased vessels. However, no statistically significant correlation was found between PDW and number of diseased vessels (p=0.246).Conclusions: The study concludes that MPV should be considered as an effective tool in predicting the magnitude of acute events in patients with coronary artery disease. However, larger studies with morphological and functional estimation of platelet indices are required to prove this.

Study on Vitamin D deficiency in patients of diabetes mellitus presenting with Acute Coronary syndrome in a tertiary care hospital in South India

2020 ◽  
Vol 11 (5) ◽  
pp. 49-53
Author(s):  
Archana Bhat ◽  
Arunachalam Ramachandran ◽  
Pradeep Periera ◽  
Akshatha Rao Aroor
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Vitamin D ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Vitamin D Deficiency ◽  
Coronary Syndrome ◽  
Vitamin D Levels ◽  
Luminal Stenosis ◽  
Artery Disease

Background: Vitamin D, a fat-soluble vitamin has its receptor present in myriad of tissues and it modulates multiple cellular processes. Vitamin D deficiency is reported to be associated with coronary artery disease. Cardiovascular disease is the leading cause of mortality worldwide. Aims and Objective: The primary outcome was to investigate if there is a correlation of 25-OH levels with the percentage of luminal stenosis, as measured with coronary angiogram. The secondary outcome was to determine the differences in angiographically proven luminal stenosis across categories of 25-OH vitamin D levels. Materials and Methods: Thirty patients with acute coronary syndrome with diabetes mellitus were included in this cross-sectional descriptive study. All patients were tested for fasting vitamin D levels, fasting blood sugar, HbA1C and serum creatinine. Detailed history of the patients was recorded. Data was analyzed by the statistical software SPSS version 19 and p value <0.05 was considered significant. Statistical tests like Chi- square, independent t test and log regression was used. Results: In this study 30 patients undergoing coronary angiography for acute coronary syndrome, Vitamin D levels showed severe deficiency in 6.7% (2) cases while mild deficiency was seen in 50% of the cases. Patients with single vessel disease on the coronary angiogram had lower mean HbA1C (9.18) levels in our study. Patients with triple vessel disease had poorly controlled mean HbA1C levels (10.42). Conclusion: In this study we did not find any significant difference between the serum Vitamin D deficiency levels with patients with angiographic severity of the coronary artery disease. Patients with poorly controlled diabetes mellitus had more severe angiographic proven coronary artery disease.

scholarly journals Severe Coronary Artery Disease in a Person Living with HIV

Medicina ◽  
2021 ◽  
Vol 57 (6) ◽  
pp. 595
Author(s):  
Mircea Bajdechi ◽  
Cosmin Mihai ◽  
Alexandru Scafa-Udriste ◽  
Ali Cherry ◽  
Diana Zamfir ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Severe Coronary Artery Disease ◽  
Atypical Symptoms ◽  
Coronary Syndrome ◽  
Severe Coronary Artery ◽  
Artery Disease ◽  
Living With Hiv ◽  
Missed Diagnoses

The pathophysiology of accelerated atherosclerosis in people living with Human Immunofediciency virus (HIV) is complex. Coronary artery disease (CAD) has become an important cause of mortality in these patients. They often have atypical symptoms, leading to frequently missed diagnoses. We report a case of a 51-year-old male undergoing antiretroviral therapy who was admitted for acute coronary syndrome. He had severe coronary artery disease that involved difficult management.

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