Comparative Platelet Releasate Proteomic Profiling of Acute Coronary Syndrome versus Stable Coronary Artery Disease

Coronary artery disease may develop slowly and create symptoms only in late stages due to marked narrowing of one or more coronary arteries. However, the disease progression can also be rapid and be triggered by disruption of a coronary arterial plaque, complicated by thrombosis, embolization, and varying degrees of obstruction to myocardial perfusion. The term acute coronary syndrome is used to denote the acute phases of ischaemic coronary artery disease with or without myocardial cell necrosis. This term is preferred to earlier symptom-related terminology because it encompasses the common underlying pathophysiology. The clinical features depend upon the extent and severity of myocardial ischaemia. Acute coronary syndrome describes the spectrum of clinical manifestations from worsening of stable coronary artery disease to large myocardial infarction with shock or sudden cardiac death.

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Evaluation of antibodies to oxidized low-density lipoprotein and assessment of C-reactive protein in acute coronary syndrome and stable coronary artery disease

Thrombosis and Haemostasis ◽

10.1160/th06-10-0561 ◽

2007 ◽

Vol 98 (08) ◽

pp. 413-419 ◽

Cited By ~ 12

Author(s):

Pal Soltesz ◽

Katalin Veres ◽

Renata Laczik ◽

Henrietta Der ◽

Istvan Csipo ◽

...

Keyword(s):

Coronary Artery Disease ◽

Acute Coronary Syndrome ◽

Coronary Artery ◽

Stable Coronary Artery Disease ◽

Clinical State ◽

C Reactive Protein ◽

Reactive Protein ◽

Coronary Syndrome ◽

Artery Disease ◽

Stable Cad

SummaryThe aim was to measure the level of antibodies to oxidized LDL (oxLDL) and C-reactive protein (CRP) in the serum of patients with acute coronary syndrome (ACS). The results were correlated with data obtained from patients with stable coronary artery disease (stable CAD) and healthy controls.Thirty-three patients with ACS and 62 stable CAD patients were enrolled in the study. Fifty healthy individuals served as controls.The evaluation of anti-oxLDL autoantibodies was performed by ELISA, while CRP levels were measured by turbidimetry. The level of antibodies to oxLDL was significantly higher in both groups of patients with ACS and stable CAD compared to controls.The comparison between the acute and stable groups showed that anti-oxLDL levels were higher in the acute group,but because of high SD, the difference was not significant. By performing group analysis, anti-oxLDL levels were found to be significantly higher in ACS patients with unstable clinical state (circulatory insufficiency, malignant arrhythmias, recurring ischemic pain, need for urgent coronary intervention and death). CRP level in patients with ACS was significantly higher than in those with stable CAD. A positive correlation was found between anti-oxLDL antibodies and CRP levels both in patients with ACS and stable CAD. The association between the two biomarkers was stronger in the ACS group. In conclusion, our findings support the notion that the presence of antibodies to oxLDL, a plaquespecific antigen, plays a major role as a predictor of complicated manifestations of ACS.

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