scholarly journals Antianginal Efficacy of Ivabradine in Patients With History of Coronary Revascularization

Angiology ◽  
2016 ◽  
Vol 68 (1) ◽  
pp. 10-18 ◽  
Author(s):  
J. Zarifis ◽  
V. Grammatikou ◽  
M. Kallistratos ◽  
A. Katsivas
Keyword(s):  
Quality Of Life ◽  
Stable Angina ◽  
Coronary Revascularization ◽  
History Of ◽  
Artery Disease ◽  
Noninterventional Study ◽  
Revascularization Procedures ◽  
Post Hoc ◽  
Antianginal Efficacy

Although coronary revascularization procedures are widely performed in patients with coronary artery disease (CAD), angina is often reported, even after such procedures. This study evaluated the antianginal efficacy and effect of ivabradine treatment on quality of life (QOL) in patients with CAD and history of coronary revascularization. This is a post hoc analysis (926 post-revascularization patients) of a prospective, noninterventional study, which included 2403 patients with CAD and stable angina. The data were recorded at baseline, at 1 month and 4 months after inclusion. After ivabradine administration, mean number of anginal events decreased from 2.2 ± 2.3 (median: 2.0, minimum: 0.0, maximum: 21.0, range: 21.0) to 0.3 ± 0.6 (median: 0.0, minimum: 0.0, maximum: 7.0, range: 7.0) times/week ( P < .001), while nitroglycerin consumption decreased from 1.5 ± 2.2 (median: 1.0, minimum: 0.0, maximum: 20.0, range: 20.0) to 0.1 ± 0.4 times/week (median: 0.0, minimum: 0.0, maximum: 5.0, range: 5.0; P < .001). Quality of life improved at study completion compared to baseline ( P < .001). Ivabradine addition on top of optimal individualized dose of β-blockers is associated with decreased anginal events and improvement in QOL in patients with stable angina and history of coronary revascularization.

Abstract 12585: Antianginal Efficacy of Ivabradine in Patients With History of Coronary Revascularization

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Ioannis Zarifis ◽  
Violetta Grammatikou ◽  
Emmanouil Kallistratos ◽  
Apostolos Katsivas
Keyword(s):  
Quality Of Life ◽  
Coronary Revascularization ◽  
Symptomatic Treatment ◽  
History Of ◽  
Β Blocker ◽  
Study Completion ◽  
Artery Disease ◽  
Revascularization Procedures ◽  
Post Hoc

Introduction: Coronary revascularization procedures are widely performed for the symptomatic treatment of patients with coronary artery disease (CAD). Even after such procedures, angina symptoms often remain. Hypothesis: To evaluate the antianginal effectiveness and the effect on quality of life of ivabradine co-administered with a β-blocker, during 4-month therapy of CAD patients with a history of coronary revascularization. Methods: This is a post hoc analysis (926 post-revascularization patients) of a Pan-Hellenic, prospective, non interventional study including 2403 patients with CAD and stable angina. Data were recorded at baseline, and at 1 and 4 months after inclusion, while patients’ quality of life was assessed by means of the EQ-5D questionnaire. Results: Of 926 CAD patients who participated in the study, 28 (3%) prematurely discontinued treatment. Addition of ivabradine decreased mean heart rate from 80.3±9.5 bpm (1st visit) to 67.8±7.3 bpm (2nd visit) and 63.9±6.2 bpm (3rd visit) (P<0.001). Mean number of angina attacks and nitroglycerin consumption decreased, respectively, from 2.2±2.3/1.5±2.2 times/week (1st visit) to 0.5±1.0/0.3±0.8 (2nd visit) and 0.3±0.6/0.1±0.4 times times/week (3rd visit) (P<0.001). Moreover, the percentage of patients with angina CCS I (Canadian Cardiovascular Society classification) increased from 36% at baseline to 83% at study completion (P<0.001), while those with angina CCS III-IV decreased from 21% to 2% (P<0.001). All dimensions of the EQ-5D questionnaire were significantly improved after 4 months of treatment with ivabradine (P<0.001) (Table 1). Compliance with ivabradine treatment was high. Throughout the trial, 884 patients (95.5%) were taking their treatment “every day” or “quite often.” Conclusions: These results confirm the antianginal effectiveness as well as the beneficial effect of ivabradine on the quality of life of patients with CAD and a history of coronary revascularization.

scholarly journals The argument of the ORBITA study: angioplasty is useless

2020 ◽  
Vol 22 (Supplement_E) ◽  
pp. E34-E36
Author(s):  
Leonardo Bolognese
Keyword(s):  
Quality Of Life ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Functional Capacity ◽  
Coronary Angioplasty ◽  
Stable Coronary Artery Disease ◽  
Artery Disease ◽  
Revascularization Procedures ◽  
Vessel Coronary Artery

Abstract The goal of treatment in stable coronary artery disease is to improve prognosis and quality of life of the patients. International Guidelines support revascularization procedures for symptomatic patients unresponsive to optimal medical treatment. Previous studies demonstrated, in fact, the therapeutic efficacy of coronary angioplasty in reducing angina and improving the functional capacity of these patients. The ORBITA study, recently published, challenged these assertions by demonstrating the lack of benefit of angioplasty over placebo in terms of effort tolerance in a population of patients with single-vessel coronary artery disease. What lesson could we learn from the ORBITA study?

scholarly journals Gender differences in quality of life in coronary artery disease patients with comorbidities undergoing coronary revascularization

PLoS ONE ◽  
2020 ◽  
Vol 15 (6) ◽  
pp. e0234543 ◽  
Author(s):  
Tom H. Oreel ◽  
Pythia T. Nieuwkerk ◽  
Iris D. Hartog ◽  
Justine E. Netjes ◽  
Alexander B. A. Vonk ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Coronary Artery Disease ◽  
Gender Differences ◽  
Coronary Artery ◽  
Coronary Revascularization ◽  
Artery Disease

scholarly journals Differences between Slovak and Dutch patients scheduled for coronary artery bypass graft surgery regarding clinical and psychosocial predictors of physical and mental health-related quality of life

2017 ◽  
Vol 17 (4) ◽  
pp. 324-335 ◽  
Author(s):  
Noha El-Baz ◽  
Daniela Ondusova ◽  
Martin Studencan ◽  
Jaroslav Rosenberger ◽  
Sijmen A Reijneveld ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Coronary Artery ◽  
Health Related Quality ◽  
Symptoms Of Depression ◽  
Type D ◽  
Related Quality ◽  
Health Related ◽  
History Of ◽  
Artery Disease

Background: Differences in health-related quality of life in coronary artery disease patients and associated factors between patients of central and western European descent are rarely investigated. We aim to test differences between Dutch and Slovak health-related quality of life, whether nationality predicted health-related quality of life and if standardised beta weights of health-related quality of life determinants differ across countries. Design: An observational multicentre study at university cardiac centres in the Netherlands and Slovakia. Methods: In 226 coronary artery disease patients, health-related quality of life was measured by the Short Form Health Survey 36, anxiety and depression were measured using the Hospital Anxiety and Depression Scale, and type D personality was assessed with the 14-item Type D Scale. Multivariate analysis was used to explore the effect of patient characteristics on the physical and mental component summaries. Estimates of each predictor’s beta value of the physical and mental component summaries in the Slovak and Dutch patient sample were separately calculated using the Cummings criterion for comparison of two independent betas. Results: Stronger predictors of physical health-related quality of life in Slovak patients were educational level, current smoking, poor functional status, history of diabetes and amount of social support. In Dutch patients, only more symptoms of depression was a stronger predictor ( P<0.05). Regarding Slovak mental health-related quality of life, stronger predictors were educational level, current smoking and amount of social support. Female gender, history of myocardial infarction and more symptoms of depression were stronger predictors in Dutch patients ( P<0.05). Conclusion: Descent and differences between both populations in determinants of health-related quality of life should be considered while planning care, follow-up, health education and rehabilitation.

Management of stable angina

2010 ◽  
pp. 2902-2911
Author(s):  
Adam D. Timmis
Keyword(s):  
Coronary Revascularization ◽  
Obstructive Coronary Artery Disease ◽  
Clinical History ◽  
Direct Proportion ◽  
Atypical Symptoms ◽  
Referral Decisions ◽  
Specialist Services ◽  
History Of ◽  
Artery Disease

Angina—the pain provoked by myocardial ischaemia—is usually caused by obstructive coronary artery disease that is sufficiently severe to restrict oxygen delivery to the cardiac myocytes. Quality of life is impaired in direct proportion to the severity of symptoms. Clinical history remains the most useful basis for diagnosis and referral decisions to specialist services, the commonest indications being (1) new-onset angina, (2) exclusion of angina in high-risk individuals with atypical symptoms, (3) worsening angina in a patient with previously stable symptoms, (4) new or recurrent angina in a patient with history of myocardial infarction or coronary revascularization, (5) assessment of occupational fitness (e.g. airline pilots)....

Health-related quality of life in patients with coronary artery disease after coronary revascularization

Open Medicine ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. 618-626
Author(s):  
Ivan Tasić ◽  
Gordana Lazarević ◽  
Miomir Stojanović ◽  
Svetlana Kostić ◽  
Marija Rihter ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Revascularization ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Two Dimensions ◽  
Sf 36 ◽  
Artery Disease

AbstractThe aim of this study was to investigate the quality of life (HRQoL) in coronary artery disease(CAD) patients, admitted for rehabilitation within 3 months after an acute coronary event, in relation to treatment strategy [conservative treatment without revascularization (WR), percutaneous transluminal coronary angioplasty (PTCA), coronary artery bypass graft (CABG)]. Methods: Overall 719 consecutive CAD patients were involved in the study: WR (n=170), PTCA (n=226), CABG (n=323). HRQoL was estimated using the SF-36 questionnaire for total QoL and its two dimensions for physical and mental health [physical and mental component scores (PCS, MCS)]. Sexual dysfunction was assessed using the ASEX scale. Results: Significantly higher PCS, MCS and total SF-36, but lower ASEX score, were found in men compared with women. The ASEX score was significantly affected by age. Significantly higher PCS was found in PTCA group compared with that of CABG group. In multivariate analysis a significant positive association was obtained between PCS/MCS and male sex, between regular exercise, hyperlipoproteinemia, and permanent stress. ASEX was significantly positively associated with the age, CHF and non smoking. Conclusion: The results of this study have demonstrated significantly better HRQoL in men, younger CAD patients, patients who underwent PTCA and in patients without self-reported exposition to stress.

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