Systemic Immune-Inflammation Index May Predict the Development of Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction

Angiology ◽  
2021 ◽  
pp. 000331972110300
Author(s):  
Ali Bağcı ◽  
Fatih Aksoy ◽  
Hasan Aydin Baş
Keyword(s):  
Myocardial Infarction ◽  
Characteristic Curve ◽  
Contrast Induced Nephropathy ◽  
Predictive Capacity ◽  
St Segment Elevation ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Immune Inflammation

The aim of this study was to investigate the predictive capacity of a systemic immune-inflammation index (SII) in the detection of contrast-induced nephropathy (CIN) following ST-segment elevation myocardial infarction (STEMI). A total of 477 STEMI patients were enrolled in the study. The patients were divided into 2 groups according to CIN development. A cutoff point of 5.91 for logarithm-transformed SII was identified with 73.0% sensitivity and 57.5% specificity to predict CIN following STEMI. According to a pairwise analysis of receiver operating characteristic curve analysis, the predictive power of SII in detecting CIN following STEMI was similar to that of high-sensitivity C-reactive protein and better than the neutrophil/lymphocyte ratio or platelet/lymphocyte ratio. As a result, SII can be used as one of the independent predictors of CIN after STEMI.

Systemic Immune-Inflammation Index Is a Predictor of Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction

Angiology ◽  
2021 ◽  
pp. 000331972110290
Author(s):  
Recep Öztürk ◽  
Duygu İnan ◽  
Barış Güngör
Keyword(s):  
Myocardial Infarction ◽  
Coronary Intervention ◽  
Contrast Induced Nephropathy ◽  
St Segment Elevation ◽  
Lymphocyte Ratio ◽  
Protein Levels ◽  
The Third ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Immune Inflammation

We evaluated the predictive value of admission systemic immune-inflammation index (SII) for the risk of contrast-induced nephropathy (CIN) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and SII (platelet × NLR) levels were calculated in 1621 consecutive patients with STEMI. The relationship of these parameters with CIN development within 72 hours of pPCI was analyzed. Of the study population, 343 (21.1%) cases developed CIN. The frequency of CIN was 11.1% in the first SII quartile, 11.6% in the second SII quartile, 26.8% in the third SII quartile, and 35% in the fourth SII quartile, which differed significantly between groups ( P < .01). Age, baseline glomerular filtration rate, contrast media volume, hypertension, C-reactive protein levels, and the quartiles of SII were independent predictors of CIN. Patients in the third SII quartile versus first SII quartile (OR: 2.906, 95% CI, 1.903-4.437; P < .001), and fourth SII quartile versus first SII quartile (OR: 4.168, 95% CI, 2.754-6.313; P < .001) had a significantly higher risk for CIN in the multivariable model. The SII may be a promising inflammatory parameter to predict CIN after pPCI.

Systemic Immune Inflammation Index: A Novel Predictor of Contrast-Induced Nephropathy in Patients With Non-ST Segment Elevation Myocardial Infarction

Angiology ◽  
2021 ◽  
pp. 000331972110077
Author(s):  
Saban Kelesoglu ◽  
Yucel Yilmaz ◽  
Deniz Elcık ◽  
Zeki Çetınkaya ◽  
Mehmet Tugrul Inanc ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Characteristic Curve ◽  
High Sensitivity ◽  
Coronary Intervention ◽  
Contrast Induced Nephropathy ◽  
St Segment Elevation ◽  
Glucose Levels ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Immune Inflammation

We investigated whether the systemic immune inflammation index (SII) on admission is an independent risk factor that predicts the development of contrast-induced nephropathy (CIN) in patients with non-ST segment elevation myocardial infarction (NSTEMI) who underwent percutaneous coronary intervention (PCI). A total of 429 patients with NSTEMI were enrolled in the study. Contrast-induced nephropathy was defined as an increase in serum creatinine level of ≥0.5 mg/dL or ≥25% above baseline within 72 hour after the procedure. Patients were divided into 2 groups: with and without CIN. Demographics, clinical risk factors, angiographic and laboratory parameters, CIN incidence, and SII score were compared between the 2 groups. Non-ST segment elevation myocardial infarction patients, who developed CIN, had higher glucose levels ( P = .009), neutrophil counts ( P < .001), platelet counts ( P < .001), neutrophil-lymphocyte ratios ( P < .001), high sensitivity C-reactive protein levels ( P = .009), and SII levels ( P < .001) than those who did not develop CIN. The receiver operating characteristic curve analysis showed that at a cutoff of 933.2, the value of SII exhibited 77.6% sensitivity and 69.2% specificity for detecting CIN. Our study showed that the SII levels on admission were independently associated with CIN development after PCI in patients with NSTEMI.

Systemic immune–inflammation index predicts new onset atrial fibrillation after ST elevation myocardial infarction

2021 ◽  
Author(s):  
Ali Bağcı ◽  
Fatih Aksoy
Keyword(s):  
Myocardial Infarction ◽  
Atrial Fibrillation ◽  
Characteristic Curve ◽  
Predictive Capacity ◽  
St Segment Elevation ◽  
Lymphocyte Ratio ◽  
Reactive Protein ◽  
Immune Inflammation ◽  
Onset Atrial Fibrillation ◽  
New Onset

Aim: To investigate the predictive capacity of a systemic immune–inflammation index (SII) in detecting new onset atrial fibrillation (NOAF) following ST segment elevation myocardial infarction (STEMI). Patients & methods: A total of 402 STEMI patients were enrolled in the study. The patients were divided into two groups according to NOAF development. Results: A cut-off point of 1,228,000 for SII was identified with 60% sensitivity and 78.1% specificity to predict NOAF following STEMI. According to pairwise analysis of receiver operating characteristic curve analysis, the predictive power of SII in detecting NOAF following STEMI was similar to high-sensitive C-reactive protein, and better than neutrophil-to-lymphocyte ratio or platelet-to-lymphocyte ratio. Conclusion: SII can be used as one of the independent predictors of NOAF following STEMI.

Correlation of Platelet-Lymphocyte Ratio (PLR) and Contrast-Induced Nephropathy (CIN) in Patients with ST-Segment Elevation Myocardial Infarction (STEMI) Undergoing Primary Percutaneous Coronary Intervention (PCI)

2021 ◽  
Vol 4 (2) ◽  
Author(s):  
Steven Winardi ◽  
Andika Sitepu
Keyword(s):  
Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Primary Percutaneous Coronary Intervention ◽  
Coronary Intervention ◽  
Contrast Induced Nephropathy ◽  
St Segment Elevation ◽  
Lymphocyte Ratio ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Percutaneous Coronary

Acute Coronary Syndrome (ACS) is a series of clinical disorders caused by acute ischemic heart disease. The clinical spectrum of ACS is unstable angina pectoris (UAP), non  ST segment elevation myocardial infarction (NSTEMI) and ST segment elevation myocardial infarction (STEMI). Inflammation occurs from the early stages of atheroma formation to plaque rupture and thrombosis. Thrombocytosis and lymphopenia are associated with the degree of systemic inflammation and the platelet lymphocyte ratio (PLR) is a new marker involving both hematological indices. ST segment elevation myocardial infarction is a type of acute myocardial infarction with high mortality. Management of STEMI patients is carried out with reperfusion therapy consisting of primary percutaneous coronary intervention (PCI) and fibrinolytics. Contrast-induced nephropathy is a serious complication of angiograph procedures that results from administration of contrast media.

Platelet to Lymphocyte Ratio Predicts Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Angiology ◽  
2017 ◽  
Vol 69 (1) ◽  
pp. 71-78 ◽  
Author(s):  
Xi-peng Sun ◽  
Jing Li ◽  
Wei-wei Zhu ◽  
Dong-bao Li ◽  
Hui Chen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Coronary Intervention ◽  
Platelet To Lymphocyte Ratio ◽  
Contrast Induced Nephropathy ◽  
St Segment Elevation ◽  
Lymphocyte Ratio ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Percutaneous Coronary

We investigated the relationship between platelet to lymphocyte ratio (PLR) and contrast-induced nephropathy (CIN) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). We enrolled 5719 patients in 3 tertiary hospitals from January 2005 to December 2010. The PLR was calculated as the ratio of platelet to lymphocyte counts on admission. Serum creatinine level was measured before and within 72 hours after contrast medium administration. To evaluate the relation between PLR and CIN, the 5719 patients were divided into a CIN group and a non-CIN group. Contrast-induced nephropathy occurred in 252 (4.4%) patients. Patients in the CIN group had significantly higher PLR than those in the non-CIN group (173.8 [62.3] and 116.2 [51.7], respectively; P < .001). In logistic regression analysis, PLR was an independent predictor of CIN (odds ratio: 1.432, 95% confidence interval: 1.205-1.816, P = .031), along with age, diabetes mellitus, creatinine, estimated glomerular filtration rate, and neutrophil to lymphocyte ratio. In conclusion, a higher PLR was an independent risk factor for the development of CIN in patients with STEMI undergoing pPCI.

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