Pediatric Intraparotid Castleman's Disease

2003 ◽  
Vol 112 (9) ◽  
pp. 813-816 ◽  
Author(s):  
Daniel S. Samadi ◽  
Neil G. Hockstein ◽  
Lawrence W. C. Tom
Keyword(s):  
Head And Neck ◽  
Clinical Course ◽  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Cell Type ◽  
Radiographic Findings ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Plasma Cell Type ◽  
Histologic Types

Castleman's disease (CD) is a rare, benign lymphoepithelial disease of unknown cause that presents most commonly in the mediastinum. There are 2 histologic types of CD: the hyaline vascular type and the plasma cell type. In the head and neck, 98% of these lesions are of the hyaline vascular type. The differential diagnosis of CD includes reactive lymphadenopathy, lymphoproliferative disorders, lymph node metastasis, and other conditions. Approximately 80 cases of CD have been reported in children; head and neck involvement in children is extremely rare. A case of a child with intraparotid CD is presented; the clinical course, histopathologic presentation, radiographic findings, and management of CD are reviewed.

Rituximab Therapy for HIV-Negative Multicentric Castleman’s Disease: Seven Years’ Experience at a Single Institute

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 4998-4998
Author(s):  
Makoto Ide ◽  
Yasunori Kawachi ◽  
Yoichiro Izumi
Keyword(s):  
Plasma Cell ◽  
Castleman’S Disease ◽  
Cell Type ◽  
Multicentric Castleman’S Disease ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Plasma Cell Type ◽  
Multicentric Castleman's Disease ◽  
Hiv Negative

Abstract Background: Multicentric Castleman’s disease (MCD) is an indolent lymphoproliferative disorder of unknown etiology, and is classified into three types: hyaline-vascular type, plasma-cell type, and mixed type. Recently, we reported the use of rituximab therapy for HIV-negative patients with MCD, after obtaining the informed consent of the patient and the approval of the Institutional Review Board (Br J Haematology 121, 818–819, 2003, Eur J Haematology 76. 119–123. 2006). Therefore, we tried to review the long-term follow-up (nine to 75 months) of all patients at a single institute. Patients and Methods: Over seven years, 5 HIV-negative patients with MCD (3 men and 2 women; median age: 39, range: 26–61 years) were referred to Takamatsu Red Cross hospital. After clinical evaluation (chest and abdominal computed tomography scans, magnetic resonance imaging and Ga67 citrate scintigrams), lymphnode biopsy was performed for histological diagnosis. Rituximab was administered intravenously at a standard dose of 375 mg/m2 weekly, for 4 or 8 times without chemotherapy, and we analyzed the clinical course of MCD after rituximab therapy. During the follow-up, clinical symptoms were recorded. At a median follow-up of 49 months, biologic parameters (complete blood count, C-reactive protein, immunoglobulin G), and cytokines (soluble interleukin-2 receptor, Interleukin-6) were determined at different time points by standard procedures. Results: Three of the five patients had histological evidence of hyaline-vascular type MCD, and two patients had plasma-cell type MCD. Two (both with hyaline vascular type) of the five MCD patients (40%) with MCD achieved almost complete remission with rituximab therapy when followed up for 50 to 75 months. Three (one with hyaline vascular type and two with plasma-cell type) of the five patients did not show clinical remission after riruximab administration. Conclusion;Rituximab treatment provides a durable response in a some MCD (especially those with hyaline-vascular type) patients, but is not always successful.

scholarly journals Unicentric Castleman’s Disease in a Man Originally Diagnosed with Sarcoidosis: A Case and Analysis of the Key Differences in Diagnosis

2019 ◽  
Vol 4 (4) ◽  
Keyword(s):  
Lymph Nodes ◽  
Surgical Resection ◽  
Lymphoproliferative Disorder ◽  
Castleman’S Disease ◽  
Castleman Disease ◽  
Castleman's Disease ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Complete Surgical Resection ◽  
Vascular Proliferation

Castleman Disease (CD) is a lymphoproliferative disorder characterized by enlarged hyperplastic lymph nodes with regressed follicles surrounded by expanded mantle zones of small lymphocytes, and interfollicular vascular proliferation in the hyaline-vascular type. There are two types: unicentric and multicentric. Unicentric, hyalinevascular type of Castleman’s disease can be treated successfully with complete surgical resection with monitoring for reoccurrence. Here we report a case of a patient originally diagnosed with sarcoidosis who was found to have Unicentric Castleman’s disease.

scholarly journals Abdominal localization of unicentric form of Castleman disease: A case report

2017 ◽  
Vol 74 (4) ◽  
pp. 367-370
Author(s):  
Bosko Milev ◽  
Borka Milev ◽  
Zoran Kostic ◽  
Darko Mirkovic ◽  
Nenad Perisic ◽  
...  
Keyword(s):  
Case Report ◽  
Plasma Cell ◽  
Castleman Disease ◽  
Mr Enterography ◽  
Unknown Etiology ◽  
Cell Type ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Plasma Cell Type ◽  
Golden Standard

Introduction. Castleman disease is a rare disease of the unknown etiology, occuring in two clinical forms: unicentric or multicentric. It is characterized by the hyperplasia of lymph glands. In literature the four pathohistological forms were described: hyaline vascular type, plasma cell type, mixed type and a recently recognized plasmablastic type. The most frequent changes are localized in the mediastinum, while the abdominal localization is with significatly rare occurrence, and that was the motive for presentation of this case. Case report. In a 41-year old male magnetic resonance (MR) enterography showed a change in the ileocecal area without the presence of subjective symptoms of digestive tract and without loss of body mass. Due to the suspicion of stromal tumor, surgical intervention was indicated. Pathohistological findings showed Castleman lymphadenopathia reactiva mesenterii (plasma cell type) which was in the unicentric form. There were present only anaemia and the increased value of sedimentation from the laboratory analyses. Conclusion. Abdominal localization of unicentric plasma cell form occurs rarely and the surgical method of treatment presents the golden standard as it was shown in the presented case.

scholarly journals Castleman’s disease: an entity forgotten in ENT

2021 ◽  
Vol 7 (5) ◽  
pp. 905
Author(s):  
Mohamed Riyas Ali ◽  
Vikram Wadhwa ◽  
Ravi Meher ◽  
Reena Tomar ◽  
Karishma Singh ◽  
...  
Keyword(s):  
Castleman’S Disease ◽  
Treatment Modalities ◽  
Retropharyngeal Space ◽  
Castleman's Disease ◽  
Complete Excision ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Systemic Lymphadenopathy ◽  
Rare Site ◽  
Usual Site

<p class="abstract">Castleman’s disease (CD) usually presents as localized or systemic lymphadenopathy or as an extra nodal mass. The usual site of presentation are mediastinum, retroperitoneum, axilla and mesentery. Only 3 cases of CD have been reported in retro pharyngeal space. We report a case of 20 year old male patient with retropharyngeal mass. He presented with difficulty in swallowing, change in voice and respiratory distress. The mass was removed in-toto transorally after performing elective tracheostomy. The histopathological findings were consistent with hyaline vascular type of CD. He was decannulated after two day and postoperative period was uneventful. Postoperative CT imaging confirmed the complete excision of tumor and patient is on follow up, with no signs of recurrence. The presentation of tumour in the retropharyngeal space which is a rare site of occurrence add to the uniqueness of this case. Unicentric CD has an excellent prognosis and surgery is the management of choice. Its clinical features, histological subtypes, treatment modalities and prognosis are discussed.</p>

scholarly journals Successful Treatment of Mediastinal Unicentric Castleman’s Disease Using Video-Assisted Thoracoscopic Surgery with Preoperative Embolization

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Yosuke Amano ◽  
Daiya Takai ◽  
Nobuya Ohishi ◽  
Aya Shinozaki-Ushiku ◽  
Masashi Fukayama ◽  
...  
Keyword(s):  
Thoracoscopic Surgery ◽  
Castleman’S Disease ◽  
Preoperative Embolization ◽  
Castleman's Disease ◽  
Tumor Vascularity ◽  
Mediastinal Tumors ◽  
Video Assisted ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Video Assisted Thoracoscopic Surgery

Unicentric Castleman’s disease is a rare, benign lymphoproliferative disorder that is curable with surgical resection. However, significant bleeding often occurs during surgery because of tumor hypervascularity. We herein present a case of hyaline-vascular-type mediastinal unicentric Castleman’s disease, successfully resected using video-assisted thoracoscopic surgery with preoperative embolization. In the present case, tumor hypervascularity and feeding vessels were revealed by computed tomography (CT), which led us to perform preoperative angiography and embolization to the tumor feeding arteries to reduce intraoperative bleeding. Castleman’s disease should be considered in the differential diagnosis of hypervascular mediastinal tumors. Tumor vascularity should be assessed prior to surgery, and preoperative embolization should be considered.

scholarly journals Retroperitoneal pararenal castleman’s disease: a case report

2013 ◽  
Vol 3 (6) ◽  
pp. 509-511
Author(s):  
S Shrestha ◽  
U Nepal ◽  
N Lamichhane ◽  
P Chhetri
Keyword(s):  
Preoperative Diagnosis ◽  
Histopathological Examination ◽  
Castleman’S Disease ◽  
Accurate Diagnosis ◽  
Renal Tumors ◽  
Unknown Etiology ◽  
Resected Specimen ◽  
Castleman's Disease ◽  
Vascular Type ◽  
Hyaline Vascular Type

Castleman’s diseas is a rare lymphoproliferative disorder of unknown etiology. We report a 28 years old woman with solitary Castleman’s disease in the left pararenal space. This case was diagnosed preoperatively as renal cell carcinoma. The patient underwent a radical nephrectomy with dissection of pararenal mass. Histopathological examination of the surgically resected specimen showed the hyaline vascular type of Castleman’s disease. A preoperative diagnosis of Castleman’s disease is difficult; therefore, a surgical resection and histopathological evaluation can provide an accurate diagnosis of tumor. Taking this case into consideration, we suggest that Castleman’s disease should be included in the differential diagnosis of renal tumors. DOI: http://dx.doi.org/10.3126/jpn.v3i6.9004 Journal of Pathology of Nepal (2013) Vol. 3, 509-511

Rare case of the hyaline vascular type of Castleman's disease of the kidney

2007 ◽  
Vol 14 (12) ◽  
pp. 1098-1100 ◽  
Author(s):  
Koji. Hatano ◽  
Shigeki Fujita ◽  
Yuichi Tsujimoto ◽  
Tsuyoshi Takada ◽  
Masato Honda ◽  
...  
Keyword(s):  
Rare Case ◽  
Castleman’S Disease ◽  
Castleman's Disease ◽  
Vascular Type ◽  
Hyaline Vascular Type
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