Bronchoscopy in the Staging and Evaluation of Head and Neck Carcinoma

1983 ◽  
Vol 92 (4) ◽  
pp. 373-376 ◽  
Author(s):  
Bruce Leipzig

There is no consensus of opinion regarding the use of routine bronchoscopy, either rigid or flexible, to evaluate patients with primary squamous cell carcinomas of the upper aerodigestive tract for the possibility of second synchronous primary cancers. Whereas there is certainty of the effectiveness of this endoscopy in patients with questionable lesions or masses on chest radiographs, the value of this procedure in the face of a normal, unequivocal chest radiograph remains questionable. Six patients with primary carcinomas in the upper head and neck region and normal chest radiographs were among 98 patients evaluated within the past 6 months by triple endoscopy. In three instances, a small (less than 2 cm) lesion was discovered in the tracheobronchial tree, utilizing rigid diagnostic bronchoscopy. In three other patients with positive cytology from bronchial washings, a lung primary carcinoma has not been discovered. These presumed false-positive findings add a watchword of warning. The observation of these patients provides evidence to support the routine panendoscopic evaluation of all patients with squamous cell carcinomas of the head and neck. A valid study to identify subgroups at risk to develop these cancers should be encouraged.

JAMA Oncology ◽  
2017 ◽  
Vol 3 (2) ◽  
pp. 220 ◽  
Author(s):  
Lillian L. Siu ◽  
John N. Waldron ◽  
Bingshu E. Chen ◽  
Eric Winquist ◽  
Jim R. Wright ◽  
...  

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 975 ◽  
Author(s):  
Francesco Perri ◽  
Francesco Longo ◽  
Francesco Caponigro ◽  
Fabio Sandomenico ◽  
Agostino Guida ◽  
...  

Head and neck squamous cell carcinomas (HNSCCs) are a very heterogeneous group of malignancies arising from the upper aerodigestive tract. They show different clinical behaviors depending on their origin site and genetics. Several data support the existence of at least two genetically different types of HNSCC, one virus-related and the other alcohol and/or tobacco and oral trauma-related, which show both clinical and biological opposite features. In fact, human papillomavirus (HPV)-related HNSCCs, which are mainly located in the oropharynx, are characterized by better prognosis and response to therapies when compared to HPV-negative HNSCCs. Interestingly, virus-related HNSCC has shown a better response to conservative (nonsurgical) treatments and immunotherapy, opening questions about the possibility to perform a pretherapy assessment which could totally guide the treatment strategy. In this review, we summarize molecular differences and similarities between HPV-positive and HPV-negative HNSCC, highlighting their impact on clinical behavior and on therapeutic strategies.


1983 ◽  
Vol 91 (2) ◽  
pp. 136-142 ◽  
Author(s):  
Tsuneo Watanabe ◽  
J. Dirk Iglehart ◽  
Dani P. Bolognesi ◽  
Edwin B. Cox ◽  
Anna Vaughn ◽  
...  

Secretory immunoglobulin A (SlgA) is a major component of the secretory immune system and has been demonstrated in the sera of patients with various pathologic conditions. Current studies were undertaken to quantitate secretory components (SC) in sera of patients with squamous cell carcinoma in the head and neck region by means of a sensitive double-antibody radioimmunoassay. Patients with head and neck carcinoma were found to have threefold higher levels of SC (1.54 ± 0.74 mg/ml) compared to normal controls (0.51 ± 0.22mg/ml, P < .0001). Of interest was that the sera of patients who had successfully been treated 2 to 6 months prior to the study demonstrated statistically lower levels than those of patients with untreated carcinoma or recurrent disease. SC in sera appears to be in the form of SlgA. The origin and diagnostic significance of SC are briefly discussed.


Cancer ◽  
2005 ◽  
Vol 104 (7) ◽  
pp. 1408-1417 ◽  
Author(s):  
Johannes A. Langendijk ◽  
Ben J. Slotman ◽  
Isaac van der Waal ◽  
P. Doornaert ◽  
Johannes Berkof ◽  
...  

Head & Neck ◽  
2001 ◽  
Vol 23 (4) ◽  
pp. 298-304 ◽  
Author(s):  
Mario Airoldi ◽  
Antonella De Stefani ◽  
Sara Marchionatti ◽  
Fulvia Pedani ◽  
Pietro Gabriele ◽  
...  

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