Elevated Serum Secretory Immunoglobulin a Levels in Patients with Head and Neck Carcinoma

1983 ◽  
Vol 91 (2) ◽  
pp. 136-142 ◽  
Author(s):  
Tsuneo Watanabe ◽  
J. Dirk Iglehart ◽  
Dani P. Bolognesi ◽  
Edwin B. Cox ◽  
Anna Vaughn ◽  
...  
Keyword(s):  
Head And Neck ◽  
Immunoglobulin A ◽  
Elevated Serum ◽  
Neck Region ◽  
Head And Neck Carcinoma ◽  
Secretory Immunoglobulin A ◽  
Diagnostic Significance ◽  
Head And Neck Region ◽  
Neck Carcinoma ◽  
Secretory Immunoglobulin

Secretory immunoglobulin A (SlgA) is a major component of the secretory immune system and has been demonstrated in the sera of patients with various pathologic conditions. Current studies were undertaken to quantitate secretory components (SC) in sera of patients with squamous cell carcinoma in the head and neck region by means of a sensitive double-antibody radioimmunoassay. Patients with head and neck carcinoma were found to have threefold higher levels of SC (1.54 ± 0.74 mg/ml) compared to normal controls (0.51 ± 0.22mg/ml, P < .0001). Of interest was that the sera of patients who had successfully been treated 2 to 6 months prior to the study demonstrated statistically lower levels than those of patients with untreated carcinoma or recurrent disease. SC in sera appears to be in the form of SlgA. The origin and diagnostic significance of SC are briefly discussed.

scholarly journals SAFE TRACHEOSTOMY IN HEAD AND NECK CARCINOMA PATIENTS DURING COVID ERA: METHOD AND DEMOGRAPHICS

2020 ◽  
pp. 42-43
Author(s):  
Bonny A Joseph ◽  
Sandeep Ghosh ◽  
Sanjay M Desai
Keyword(s):  
Head And Neck ◽  
Neck Region ◽  
Head And Neck Carcinoma ◽  
Surgical Oncology ◽  
Head And Neck Malignancy ◽  
Safety Measures ◽  
Head And Neck Region ◽  
Neck Malignancy ◽  
Neck Carcinoma

Introduction: Tracheostomy is inevitable in the management of many head and neck malignancy. The indications vary from supportive to palliative. During Covid-19 era, ensuring surgeon safety while performing tracheostomy is of utmost importance as tracheostomy is considered an aerosol generating procedure. Materials and methods: All the patients who underwent tracheostomy as part of the management of carcinoma of head and neck region in the department of Surgical Oncology from March till October 2020 Conclusion: Following proper safety measures while doing tracheostomy will ensure safety of the surgeon.

scholarly journals Long Non-coding RNAs as Important Biomarkers in Laryngeal Cancer and Other Head and Neck Tumours

2019 ◽  
Vol 20 (14) ◽  
pp. 3444 ◽  
Author(s):  
Alessia Maria Cossu ◽  
Laura Mosca ◽  
Silvia Zappavigna ◽  
Gabriella Misso ◽  
Marco Bocchetti ◽  
...  
Keyword(s):  
Head And Neck ◽  
Laryngeal Cancer ◽  
Neck Region ◽  
Head And Neck Carcinoma ◽  
Molecular Signatures ◽  
Head And Neck Tumours ◽  
Head And Neck Region ◽  
Neck Carcinoma ◽  
Non Coding Rnas ◽  
Pharmacological Application

Head and neck carcinoma (HNC) is a heterogeneous disease encompassing a variety of tumors according to the origin. Laryngeal cancer (LC) represents one of the most frequent tumors in the head and neck region. Despite clinical studies and advance in treatment, satisfactory curative strategy has not yet been reached. Therefore, there is an urgent need for the identification of specific molecular signatures that better predict the clinical outcomes and markers that serve as suitable therapeutic targets. Long non-coding RNAs (lncRNA) are reported as important regulators of gene expression and represent an innovative pharmacological application as molecular biomarkers in cancer. The purpose of this review is to discuss the most relevant epigenetic and histological prognostic biomarkers in HNC, with particular focus on LC. We summarize the emerging roles of long non-coding RNAs in HNC and LC development and their possible use in early diagnosis.

scholarly journals Kimura's Disease: A Case Report

2000 ◽  
Vol 79 (3) ◽  
pp. 195-199 ◽  
Author(s):  
Sebastian J. Karavattathayyil ◽  
John R. Krause
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Lymph Nodes ◽  
Head And Neck ◽  
Salivary Glands ◽  
Immunoglobulin E ◽  
Elevated Serum ◽  
Neck Region ◽  
Kimura’S Disease ◽  
Head And Neck Region

Kimura's disease is a rare, idiopathic condition that usually affects young men of Asian descent. The disease is characterized by swelling and lesions in the head and neck region, with involvement of the subcutaneous soft tissue, major salivary glands, and lymph nodes. Patients almost always have eosinophilia and elevated serum immunoglobulin E levels. The diagnosis is established by biopsy. Kimura's disease is usually self-limiting. Its etiology is unknown but is thought to be a manifestation of an aberrant allergic response. In this paper, we describe the case of a 30-year-old patient who was diagnosed with Kimura's disease at our institution.

Diagnostic significance of ultrasonography in investigations of swellings of head and neck region – A clinico-imaging study

2013 ◽  
Vol 4 (3) ◽  
pp. 129-136
Author(s):  
Vemanna Naveen Shankar ◽  
Naveen Shankar Ashwini ◽  
Gopa Kumar ◽  
Subhas Babu
Keyword(s):  
Head And Neck ◽  
Imaging Study ◽  
Neck Region ◽  
Diagnostic Significance ◽  
Head And Neck Region

Bronchoscopy in the Staging and Evaluation of Head and Neck Carcinoma

1983 ◽  
Vol 92 (4) ◽  
pp. 373-376 ◽  
Author(s):  
Bruce Leipzig
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Neck Region ◽  
Head And Neck Carcinoma ◽  
Tracheobronchial Tree ◽  
Squamous Cell Carcinomas ◽  
Chest Radiographs ◽  
Upper Aerodigestive Tract ◽  
Neck Carcinoma ◽  
The Face

There is no consensus of opinion regarding the use of routine bronchoscopy, either rigid or flexible, to evaluate patients with primary squamous cell carcinomas of the upper aerodigestive tract for the possibility of second synchronous primary cancers. Whereas there is certainty of the effectiveness of this endoscopy in patients with questionable lesions or masses on chest radiographs, the value of this procedure in the face of a normal, unequivocal chest radiograph remains questionable. Six patients with primary carcinomas in the upper head and neck region and normal chest radiographs were among 98 patients evaluated within the past 6 months by triple endoscopy. In three instances, a small (less than 2 cm) lesion was discovered in the tracheobronchial tree, utilizing rigid diagnostic bronchoscopy. In three other patients with positive cytology from bronchial washings, a lung primary carcinoma has not been discovered. These presumed false-positive findings add a watchword of warning. The observation of these patients provides evidence to support the routine panendoscopic evaluation of all patients with squamous cell carcinomas of the head and neck. A valid study to identify subgroups at risk to develop these cancers should be encouraged.

scholarly journals Radiation-induced Fibrosarcoma of the Larynx: a Case Report and Review of Literature

2021 ◽  
Author(s):  
Wei Gong ◽  
Donghai Huang
Keyword(s):  
Head And Neck ◽  
Surgical Resection ◽  
Rare Complication ◽  
Neck Region ◽  
Head And Neck Carcinoma ◽  
Malignant Tumour ◽  
Primary Treatment ◽  
Head And Neck Region ◽  
Complete Surgical Resection ◽  
Radiation Induced

Abstract Background: Radiation-induced sarcoma (RIS) is a rare complication following radiotherapy of head and neck carcinoma. It occurs mostly within the limits of the irradiated area and always suggests a poor prognosis. Case summary: Herein, we reported one case of a 61-year-old male with laryngeal squamous cell carcinoma (SCC), who had a history of surgery and radiotherapy. In 2014, this patient was admitted in our hospital for increasing hoarseness five years after surgery and radiotherapy. Finally, the patient was diagnosed as fibrosarcoma and was given total laryngectomy, the patient was died in August 2019 within following up. In addition, the clinical and pathological characteristics of similar cases and their probable tumorgenesis were also reviewed. Conclusion: RIS is increasingly important. They usually occur mostly within the limits of the irradiated area. SCC is the most common malignant tumour in the head and neck region, and radiotherapy is a primary adjuvant therapy method. For patients receiving radiotherapy, physicians should follow up more carefully for early detection the RISs. For sarcomas occurring in head and neck region, especially RIS, complete surgical resection is the primary treatment. The choice of radiotherapy and chemotherapy should be more cautious. The prognosis of primary sarcomas or RISs is still controversial. No matter primary sarcomas or RISs, we believe that complete surgical resection should be considered as a top priority in surgery.

scholarly journals Stimulated saliva composition in patients with cancer of the head and neck region

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ulrica Almhöjd ◽  
Hulya Cevik-Aras ◽  
Niclas Karlsson ◽  
Jin Chuncheng ◽  
Annica Almståhl
Keyword(s):  
Head And Neck ◽  
Total Protein ◽  
Protein Concentration ◽  
Immunoglobulin A ◽  
Neck Region ◽  
Salivary Secretion ◽  
Post Treatment ◽  
Secretion Rate ◽  
Total Protein Concentration ◽  
Head And Neck Region

Abstract Background To analyse over time changes in stimulated whole saliva regarding total protein, Immunoglobulin A (IgA), and mucin type O-glycans (mostly MUC5B and MUC7) in head and neck cancer patients. Methods 29 dentate patients (20 men and 9 women, 59 ± 8 years) treated with curative radiation therapy and chemotherapy for cancer of the head and neck region were included. The stimulated whole salivary secretion rate was determined and saliva collected at four time-points: at pretreatment, and at 6 months, 1 and 2 years post treatment. The total protein concentration was determined spectrophotometrically by using Bicinchoninic Acid assay and Immunoglobulin A (IgA) by using ELISA technique. Glycosylation pattern of salivary mucins was determined in samples collected pre- and post treatment by using LC/MS electrospray and mucin content quantified using SDS-AgPAGE gels and PAS staining. Results Compared with pretreatment, the total protein concentration was increased already at 6 months post treatment (p < 0.01), and continued to increase up to 2 years post treatment (p < 0.001). During that period no significant changes in IgA concentration was detected. At pretreatment, the output/min of both total protein and IgA was significantly higher than at all time-points post treatment. Saliva from the cancer patients showed a low abundance/no detectable MUC7, while the MUC5B level remained, compared to saliva from a healthy control. The glycomic analysis showed that the percentage of core 2 O-glycans was increased as core 1, 3 and 4 O-glycans were decreased. The level of sialylation was higher at 6 months post treatment, while sulfation was lower. Conclusion A decreased output per minute of proteins at decreased salivary secretion rate, as well as reduced sulfation of MUC5B at 6 months post treatment tended to correlate with the patients’ experience of sticky saliva and oral dryness. At 2 years post treatment, the decreased amount of IgA combined with a lowered salivary secretion rate indicate a reduced oral defense with increased risk of oral infections.

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