Comparison of Serum Osteocalcin with Total and Bone Specific Alkaline Phosphatase and Urinary Hydroxyproline: Creatinine Ratio in Patients with Paget's Disease of Bone

1994 ◽  
Vol 31 (4) ◽  
pp. 327-330 ◽  
Author(s):  
I M S Kaddam ◽  
S J Iqbal ◽  
S Holland ◽  
M Wong ◽  
D Manning
Keyword(s):  
Alkaline Phosphatase ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Serum Osteocalcin ◽  
Paget's Disease Of Bone ◽  
Urinary Hydroxyproline ◽  
Specific Alkaline Phosphatase ◽  
Bone Specific Alkaline Phosphatase ◽  
High Bone

Osteocalcin or bone Gla protein (BGP) is secreted by osteoblasts, and its serum concentration is elevated in a number of conditions with high bone turnover. A comparison of serum osteocalcin with total (TALP) and bone specific alkaline phosphatase (BALP) and urinary hydroxyproline/creatinine (OHP/Cr ratio) was performed in 13 patients with active Paget's disease of bone. BGP did not correlate significantly with either BALP or TALP, but did show a significant correlation with OHP/Cr ratio ( r = 0·76; P<0·01). BGP does not appear to be as sensitive a marker as BALP or TALP in Paget's disease.

Plasma Calcitonin in Paget's Disease of Bone

1977 ◽  
Vol 52 (3) ◽  
pp. 329-332 ◽  
Author(s):  
J. A. Kanis ◽  
G. Heynen ◽  
R. J. Walton
Keyword(s):  
Alkaline Phosphatase ◽  
Plasma Levels ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Control Subjects ◽  
Plasma Alkaline Phosphatase ◽  
And Control ◽  
Age And Sex

1. Plasma levels of immunoreactive calcitonin were measured in 22 patients with untreated Paget's disease of bone and in 22 control subjects matched for age and sex. 2. No significant differences in plasma calcitonin were found between patients and control subjects, and hormone levels did not correlate significantly with activity of plasma alkaline phosphatase. 3. These results suggest that Paget's disease of bone is not due to deficient secretion of endogenous calcitonin.

Plasma α2 HS-glycoprotein Concentration in Paget's Disease of Bone: its Possible Significance

1980 ◽  
Vol 58 (5) ◽  
pp. 435-438 ◽  
Author(s):  
B. A. Ashton ◽  
R. Smith
Keyword(s):  
Alkaline Phosphatase ◽  
Plasma Concentration ◽  
Bone Formation ◽  
Alkaline Phosphatase Activity ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Plasma Alkaline Phosphatase ◽  
Normal Adults

1. The plasma concentration of the α2HS-glycoprotein has been measured in 58 normal adults and in patients with Paget's disease of bone before (24) and during treatment (16). 2. The average plasma α2HS-glycoprotein was lower in the patients with Paget's disease than in the normal adults and was inversely related to plasma alkaline phosphatase activity (r = −0.55, n = 24, P<0.001). 3. When the patients with Paget's disease were treated with either diphosphonate or calcitonin, the plasma α2HS-glycoprotein concentration increased towards normal. In those patients treated with calcitonin, this increase was too rapid to be entirely accounted for by a cessation of bone formation.

Turnover rate of skeletal alkaline phosphatase in humans.

1982 ◽  
Vol 28 (1) ◽  
pp. 153-154 ◽  
Author(s):  
S Posen ◽  
H S Grunstein
Keyword(s):  
Alkaline Phosphatase ◽  
Half Life ◽  
Turnover Rate ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Phosphatase Activities ◽  
Biological Half Life ◽  
Skeletal Alkaline Phosphatase

Abstract Two patients with Paget's disease of bone were subjected to plasmapheresis. Alkaline phosphatase activities of serum declined sharply, but returned to preplasmapheresis values within eight to 10 days. The biological half-life of circulating skeletal alkaline phosphatase, as calculated from these experiments, is between 1.12 and 2.15 days.

Binding of serum osteocalcin to hydroxyapatite in Paget's disease of bone

1991 ◽  
Vol 14 (1) ◽  
pp. 55-65 ◽  
Author(s):  
Rosa Torres ◽  
Concepcion de la Piedra ◽  
Aurelio Rapado
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Serum Osteocalcin ◽  
Paget's Disease Of Bone
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