Usefulness of biochemical markers of bone formation (total and bone alkaline phosphatase) and bone resorption (hydroxyproline and telopeptide) in paget's disease of bone

Bone ◽  
1995 ◽  
Vol 17 (1) ◽  
pp. 100
Author(s):  
M.A. Díaz Martin ◽  
C. de la Piedra ◽  
A. Rapado
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Resorption ◽  
Bone Formation ◽  
Biochemical Markers ◽  
Paget’S Disease ◽  
Bone Alkaline Phosphatase ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Markers Of Bone Formation

Plasma α2 HS-glycoprotein Concentration in Paget's Disease of Bone: its Possible Significance

1980 ◽  
Vol 58 (5) ◽  
pp. 435-438 ◽  
Author(s):  
B. A. Ashton ◽  
R. Smith
Keyword(s):  
Alkaline Phosphatase ◽  
Plasma Concentration ◽  
Bone Formation ◽  
Alkaline Phosphatase Activity ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Plasma Alkaline Phosphatase ◽  
Normal Adults

1. The plasma concentration of the α2HS-glycoprotein has been measured in 58 normal adults and in patients with Paget's disease of bone before (24) and during treatment (16). 2. The average plasma α2HS-glycoprotein was lower in the patients with Paget's disease than in the normal adults and was inversely related to plasma alkaline phosphatase activity (r = −0.55, n = 24, P<0.001). 3. When the patients with Paget's disease were treated with either diphosphonate or calcitonin, the plasma α2HS-glycoprotein concentration increased towards normal. In those patients treated with calcitonin, this increase was too rapid to be entirely accounted for by a cessation of bone formation.

Changes in bone metabolism associated with exposure to industrial vibration

2020 ◽  
pp. 766-766
Author(s):  
A. V. Sukhova ◽  
E. N. Kryuchkova
Keyword(s):  
Bone Mineral Density ◽  
Alkaline Phosphatase ◽  
Bone Resorption ◽  
Bone Formation ◽  
Bone Metabolism ◽  
Biochemical Markers ◽  
Mineral Density ◽  
Local Vibration ◽  
Markers Of Bone Formation

The influence of general and local vibration on bone remodeling processes is investigated. The interrelations between the long - term exposure of industrial vibration and indicators of bone mineral density (T-and Z-criteria), biochemical markers of bone formation (osteocalcin, alkaline phosphatase) and bone resorption (ionized calcium, calcium/creatinine) were established.

Dichloromethylene Diphosphonate (Cl2MDP) as an Inhibitor of Bone Resorption in Paget's Disease of Bone

1980 ◽  
Vol 58 (2) ◽  
pp. 24P-24P
Author(s):  
D. L. Douglas ◽  
T. Duckworth ◽  
J. A. Kanis ◽  
C. J. Preston ◽  
J. S. Woodhead ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Dichloromethylene Diphosphonate

Plasma Calcitonin in Paget's Disease of Bone

1977 ◽  
Vol 52 (3) ◽  
pp. 329-332 ◽  
Author(s):  
J. A. Kanis ◽  
G. Heynen ◽  
R. J. Walton
Keyword(s):  
Alkaline Phosphatase ◽  
Plasma Levels ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Control Subjects ◽  
Plasma Alkaline Phosphatase ◽  
And Control ◽  
Age And Sex

1. Plasma levels of immunoreactive calcitonin were measured in 22 patients with untreated Paget's disease of bone and in 22 control subjects matched for age and sex. 2. No significant differences in plasma calcitonin were found between patients and control subjects, and hormone levels did not correlate significantly with activity of plasma alkaline phosphatase. 3. These results suggest that Paget's disease of bone is not due to deficient secretion of endogenous calcitonin.

The Therapeutic Uses of Calcitonin

1978 ◽  
Vol 23 (2) ◽  
pp. 161-165 ◽  
Author(s):  
T. J. Martin
Keyword(s):  
Bone Resorption ◽  
Therapeutic Effect ◽  
Salmon Calcitonin ◽  
Bone Pain ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Therapeutic Uses ◽  
Histological Improvement

Calcitonin is a potent hormonal inhibitor of bone resorption. Its major therapeutic effect is in the treatment of Paget's Disease of bone, in which it has been shown to reduce bone pain, lead to radiological and histological improvement in bone, and to restore abnormal biochemistry towards normal. Some patients are resistant to treatment, and in others resistance may develop during treatment. Although antibodies to pig or to salmon calcitonin develop in almost 50 per cent of treated patients it is only very rarely that resistance may be ascribed to antibodies. There are a number of other clinical states of increased resorption in which the value of calcitonin therapy has yet to be established.

scholarly journals Paget's disease of bone

2006 ◽  
Vol 50 (4) ◽  
pp. 814-822 ◽  
Author(s):  
Luiz Griz ◽  
Gustavo Caldas ◽  
Cristina Bandeira ◽  
Viviane Assunção ◽  
Francisco Bandeira
Keyword(s):  
Biochemical Markers ◽  
Bone Scan ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
European Descent ◽  
Markers Of Bone Turnover ◽  
European Colonization ◽  
Genetic And Environmental Factors

Paget's disease of bone is a focal disorder of bone remodeling accompanied initially by an increase in bone resorption, followed by a disorganized and excessive formation of bone, leading to pain, fractures and deformities. It exhibits a marked geographical variation in its prevalence. In Brazil it predominantly affects persons of European descent. The majority of the reported cases of the disease in Brazil are from Recife, owing to its peculiar mixed European colonization over approximately four centuries. The etiology is complex and involves both genetic and environmental factors. The disease is often asymptomatic and diagnosis is usually based on biochemical markers of bone turnover, radionuclide bone scan and radiological examination. Bisphosphonates, in particular zoledronic acid, are regarded as the treatment of choice for Paget's disease of bone.

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