scholarly journals The Use of Antigenic SARS-CoV-2 Point-of-Care Test: The Italian Pediatric Real-Life Experience

2021 ◽  
pp. 000992282110539
Author(s):  
Federica Ferrari ◽  
Fortunata Civitelli ◽  
Francesca Ardenti Morini ◽  
Federico Angelo Carmelo Buonaiuto ◽  
Gianluca Frega ◽  
...  
Keyword(s):  
Life Experience ◽  
Close Contact ◽  
Point Of Care ◽  
Pediatric Population ◽  
Real Life ◽  
Gastrointestinal Symptoms ◽  
Point Of Care Test ◽  
Large Numbers ◽  
History Of ◽  
Acute Rhinitis

In Italy, during the second epidemic wave of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapid antigenic (Ag) test at point-of-care (POCT) station were employed to quickly evaluate large numbers of swabs. We collected data of all children who underwent the Ag test in our hospital. All positive patients were recalled to perform reverse transcription polymerase chain reaction. A total of 2133 tests were collected over 1 month. Clinical data of 1941 children (median age = 3.7 years) were analyzed: 1343 (69.2%) patients complained of symptoms, 594 (30.6%) had a history of close contact with SARS-CoV-2-positive individuals. Among symptoms reported, acute rhinitis was the most frequent (67.9%), followed by cough (42.6%) and fever (31.5%). Among all tests, 95.8% resulted negative, 4.2% positive: 37/89 were confirmed. In confirmed cases, fever (56.2% vs 32.2%; P = .041) and gastrointestinal symptoms (18.8% vs 6.25%; P = .041) were significantly more frequent compared with negative children. The use of POCT for Ag test seems appropriate for SARS-CoV-2 screening in the pediatric population. In children, fever and gastrointestinal symptoms may constitute red flags of SARS-CoV-2.

scholarly journals Accuracy of Rapid Point-of-Care Antibody Test in patients with suspected or confirmed COVID-19

2020 ◽  
Author(s):  
Rama Vancheeswaran ◽  
Merlin L Willcox ◽  
Beth Stuart ◽  
Matthew Knight ◽  
Hala Kandil ◽  
...  
Keyword(s):  
Point Of Care ◽  
Antibody Test ◽  
Reference Laboratory ◽  
List Type ◽  
Reference Standard ◽  
Point Of Care Test ◽  
History Of ◽  
Antibody Tests ◽  
Composite Reference Standard ◽  
Rapid Antibody

AbstractObjectivesTo assess the real-world diagnostic accuracy of the Livzon point-of-care rapid test for antibodies to SARS-COV-2DesignProspective cohort studySettingDistrict general hospital in EnglandParticipants173 Patients and 224 hospital staff with a history of COVID-19 symptoms, and who underwent PCR and/or reference antibody testing for COVID-19.InterventionsThe Livzon point-of-care (POC) lateral flow immunoassay rapid antibody test (IgM and IgG) was conducted at least 7 days after onset of symptoms and compared to the composite reference standard of PCR for SARS-COV-2 plus reference laboratory testing for antibodies to SARS-COV-2. The SARS-CoV-2 RT-PCR was tested using the available molecular technology during the study time (PHE laboratories, GeneXpert® system Xpert, Xpress SARS-CoV-2 and Source bioscience laboratory). All molecular platforms/assays were PHE/NHSE approved. The reference antibody test was the Elecsys Anti-SARS-CoV-2 assay (Roche diagnostics GmBH).Main outcome measuresSensitivity and specificity of the rapid antibody testResultsThe reference antibody test was positive in 190/268 (70.9%) of participants with a history of symptoms suggestive of COVID-19; in the majority (n=312) the POC test was taken 35 days or more after onset of symptoms. The POC antibody test had an overall sensitivity of 90.1% (292/328, 95% CI 86.3 – 93.1) and specificity of 100% (68/68, 95% CI 94.7 - 100) for confirming prior SARS-CoV-2 infection when compared to the composite reference standard. Sensitivity was 97.8% (89/92, 95% CI 92.3% to 99.7%) in participants who had been admitted to hospital and 84.4% (124/147, 95% CI 77.5% to 89.8%) in those with milder illness who had never been seen in hospital.ConclusionsThe Livzon point-of-care antibody test had comparable sensitivity and specificity to the reference laboratory antibody test, so could be used in clinical settings to support decision-making about patients presenting with more than 10 days of symptoms of COVID-19.What is already known on this topic-Presence of IgG and IgM antibodies to SARS-COV-2 indicates that the person was infected at least 7 days previously and is usually no longer infectious.-Rapid point-of-care tests for antibodies to SARS-COV-2 are widely available, cheap and easy to use-Preliminary evaluations suggested that rapid antibody tests may have insufficient accuracy to be useful for testing individual patients.What this study adds-The rapid point-of-care test for antibodies to SARS-COV-2 was 90.1% sensitive and 100% specific compared to reference standards for prior infection with COVID-19.-This is comparable to reference antibody tests-The point-of-care test evaluated in this study could be used to support clinical decision-making in real time, for patients presenting with symptoms of possible COVID-19 with at least 10 days of symptoms.

scholarly journals Evaluation of a DGP Point-of-care Test for Celiac Disease in a Pediatric Population

2016 ◽  
Vol 3 (1) ◽  
pp. 7-11 ◽  
Author(s):  
Claude-Olivier Marti ◽  
Benoit Fellay ◽  
Annemarie Bürgin-Wolff ◽  
Jean-Luc Magnin ◽  
Peter Baehler
Keyword(s):  
Celiac Disease ◽  
Point Of Care ◽  
Pediatric Population ◽  
Point Of Care Test

WED 061 ‘real life’ experience with brivaracetam as add-on treatment for epilepsy

2018 ◽  
Vol 89 (10) ◽  
pp. A7.2-A7
Author(s):  
Hughes Rhiannon ◽  
Maguire Melissa ◽  
Geldard Jo ◽  
Reuber Markus
Keyword(s):  
Life Experience ◽  
Focal Epilepsy ◽  
Real Life ◽  
Service Evaluation ◽  
Serious Adverse Events ◽  
Daily Dose ◽  
History Of ◽  
The Mean ◽  
Clinical Records

BackgroundBrivaracetam received its UK licence as an adjuvant drug for focal epilepsy in adults in 2016. There is little data on its efficacy and tolerability in ‘real life’ settings. We present an interim analysis of a multicentre service evaluation of brivaracetam.MethodsData was retrospectively collected from clinical records at two UK centres of consecutive patients treated with brivaracetam and at least one follow up. Data were also extracted on previous levetiracetam use. Seizure frequency was categorised at baseline and follow-up (daily/weekly/monthly/yearly/none).Results: Of the 44 patients identified (17 male, mean age 39, range 19–66), 75% had a history of levetiracetam exposure (LE+) and 25% did not (LE−). Mean brivaracetam exposure was 10.3 months (2–21), the mean daily dose was 200 mg (50–400). Retention was 91% vs 100% in LE+ versus LE− groups at 3 months and 82% in both groups at 6 months. Seizure category improvements were seen in 20%/36.4% in the LE+ vs LE− groups, seizure category deteriorations in 0% vs 9%. There were no serious adverse events.ConclusionBrivaracetam emerges as a potentially useful adjuvant medication for focal epilepsy. It may be better tolerated by some patients than Levetiracetam and more effective than this drug.

scholarly journals Evaluation of point-of-care test calprotectin and lactoferrin for inflammatory bowel disease among children with chronic gastrointestinal symptoms

2016 ◽  
pp. cmw079 ◽  
Author(s):  
Gea A Holtman ◽  
Yvonne Lisman-van Leeuwen ◽  
Patrick F van Rheenen ◽  
Boudewijn J Kollen ◽  
Johanna C Escher ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Point Of Care ◽  
Gastrointestinal Symptoms ◽  
Point Of Care Test ◽  
Inflammatory Bowel

scholarly journals The History of Conflict between Institutional and Native Hebrew in Israel

2020 ◽  
Vol 34 ◽  
pp. 9-35
Author(s):  
Uri Mor
Keyword(s):  
Formal Language ◽  
Life Experience ◽  
Native Speakers ◽  
Real Life ◽  
National Language ◽  
The Other ◽  
Popular Discourse ◽  
Generational Identity ◽  
History Of ◽  
The One

Contemporary popular discourse on Hebrew prescriptivism betrays an interesting ambivalence: acceptance of institutional standards on the one hand and objection to normative intervention on the other. This ambivalence can be traced to the tension between the Language Committee and the Palestine Teachers’ Association during the Second Aliyah. Both advocated that Israel adopt a modern national language, but the former was in favor of a systematic language planning, while the latter was in favor of spontaneous language adoption. In the 1950s, a similar tension developed between the older generation and the Sabras (native speakers), whose generational identity had crystallized during the pre-State period. The language promoted by the former group was an institutional variety bound to a prescriptive norm, while that promoted by the latter was a native variety bound to conventional norms and real-life experience. The tension in these two episodes led to a deep cultural rift—one that is familiar to every Hebrew speaker in Israel—between the formal language of the state and the natural language of Hebrew speakers. A crosslinguistic perspective reveals a resemblance between Israeli Hebrew and European Late Dialect Selection languages, suggesting that the ambivalence towards prescriptivism in fact indicates ambivalence towards the national language, which is perceived, simultaneously, as a manifestation of a stable national identity and an institutional interference in individual speech

Evaluation of a point-of-care test based on deamidated gliadin peptides for celiac disease screening in a large pediatric population

2012 ◽  
Vol 24 (12) ◽  
pp. 1418-1423 ◽  
Author(s):  
Françoise Bienvenu ◽  
Cécile Besson Duvanel ◽  
Camille Seignovert ◽  
Paul Rouzaire ◽  
Alain Lachaux ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Point Of Care ◽  
Pediatric Population ◽  
Disease Screening ◽  
Point Of Care Test ◽  
Gliadin Peptides

scholarly journals The Strategic Alliance between Clinical and Molecular Science in the War against SARS-CoV-2, with the Rapid-Diagnostics Test as an Indispensable Weapon for Front Line Doctors

2020 ◽  
Vol 21 (12) ◽  
pp. 4446
Author(s):  
Antonio Vittorino Gaddi ◽  
Fabio Capello ◽  
Leonardo Aluigi ◽  
Pier Luigi Antignani ◽  
Annapaola Callegaro ◽  
...  
Keyword(s):  
High Speed ◽  
Strategic Alliance ◽  
Point Of Care ◽  
Low Cost ◽  
Real Life ◽  
Diagnostic Purpose ◽  
Rapid Diagnostics ◽  
Immunochromatographic Strip ◽  
Actual Problem ◽  
Point Of Care Test

Our work concerns the actual problem of spread of SARS- CoV-2 outbreak which requires fast and correct as possible answer. In current scenario, the need of rapid answer put away the imperative of proper methodology. We focus on the serogical immunoassay for diagnosis of Covid-19 as an important weapon not only for diagnostic purpose, but also for epidemiologic one. The right equilibrium between high speed, low cost and accuracy is obtained with easy-to-use decentralized point-of-care test as the colloidal gold-based immunochromatographic strip assay which detects IgM and IgG antibodies directed against SARS-CoV-2. As our aim is to evaluate the efficacy of Covid-19 rapid tests and of serological assays in real-life settings, we designed a research protocol aimed to establish how to use correctly these diagnostics, taking into account the different possible clinical and epidemiological scenarios.

scholarly journals Hipopara-Red, Real Life Experience in 322 Patients With Hypoparathyroidism

2020 ◽  
Vol 5 (2) ◽  
Author(s):  
María Belén Zanchetta ◽  
Damián Robbiani ◽  
Beatriz Oliveri ◽  
Evangelina Giacoia ◽  
Adriana Frigeri ◽  
...  
Keyword(s):  
Natural History ◽  
Clinical Management ◽  
Life Experience ◽  
Real Life ◽  
Clinical Complications ◽  
Common Causes ◽  
History Of ◽  
The Mean ◽  
Nonsurgical Patients

Abstract Context Hypoparathyroidism is a rare disease and, as such, its natural history, long-term complications, and correct clinical management remain unclear. Objective To describe the natural history and clinical characteristics of the disease. Design and Setting To present a retrospective observational analysis from 7 specialized centers in Buenos Aires, Argentina. Patients Chronic hypoparathyroid patients followed-up between 1985 and December 2018. Main Outcome Measures Data on demographics, etiology, clinical complications, biochemical parameters, dual-energy x-ray absorptiometry (DXA) values, and treatment doses were collected. Results A total of 322 subjects with chronic hypoparathyroidism were included; 85.7% were female, the mean age was 55.2 ± 16.8 years, and the mean age at diagnosis was 43.8 ± 16.8 years. Prevalence of surgical hypoparathyroidism was 90.7%, with the most common causes being thyroid carcinoma and benign thyroid disease. A history of hypocalcemia requiring hospitalization was present in 25.7% of the whole group and in 4.3% of patients who had a history of seizures. Overall, 40.9% of our patients had reported at least 1 neuromuscular symptom. Renal insufficiency was present in 22.4% of our patients and was significantly associated with age (P < 0.0001). Hyperphosphatemia was present in 42% of patients. A history of severe hypocalcemia, paresthesias, tetany, ganglia calcifications, seizures, and cataracts was significantly higher in nonsurgical patients. Conclusion Although these patients were followed-up by experienced physicians, clinical management was heterogeneous and probably insufficient to assess all the potential complications of this chronic disease. Almost 70% of the study’s group of patients met the experts’ indications for considering the use of rhPTH 1–84. Being aware of this fact is the 1st step in improving our medical management of this disease in the future.

Sign in / Sign up

Export Citation Format

Share Document