A real‐life experience of psoriatic patients with history of cancer treated with biological drugs

2019 ◽  
Vol 33 (12) ◽  
Author(s):  
G. Odorici ◽  
C. Lasagni ◽  
L. Bigi ◽  
G. Pellacani ◽  
A. Conti
Keyword(s):  
Life Experience ◽  
Real Life ◽  
Biological Drugs ◽  
History Of ◽  
History Of Cancer

scholarly journals The Use of Antigenic SARS-CoV-2 Point-of-Care Test: The Italian Pediatric Real-Life Experience

2021 ◽  
pp. 000992282110539
Author(s):  
Federica Ferrari ◽  
Fortunata Civitelli ◽  
Francesca Ardenti Morini ◽  
Federico Angelo Carmelo Buonaiuto ◽  
Gianluca Frega ◽  
...  
Keyword(s):  
Life Experience ◽  
Close Contact ◽  
Point Of Care ◽  
Pediatric Population ◽  
Real Life ◽  
Gastrointestinal Symptoms ◽  
Point Of Care Test ◽  
Large Numbers ◽  
History Of ◽  
Acute Rhinitis

In Italy, during the second epidemic wave of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapid antigenic (Ag) test at point-of-care (POCT) station were employed to quickly evaluate large numbers of swabs. We collected data of all children who underwent the Ag test in our hospital. All positive patients were recalled to perform reverse transcription polymerase chain reaction. A total of 2133 tests were collected over 1 month. Clinical data of 1941 children (median age = 3.7 years) were analyzed: 1343 (69.2%) patients complained of symptoms, 594 (30.6%) had a history of close contact with SARS-CoV-2-positive individuals. Among symptoms reported, acute rhinitis was the most frequent (67.9%), followed by cough (42.6%) and fever (31.5%). Among all tests, 95.8% resulted negative, 4.2% positive: 37/89 were confirmed. In confirmed cases, fever (56.2% vs 32.2%; P = .041) and gastrointestinal symptoms (18.8% vs 6.25%; P = .041) were significantly more frequent compared with negative children. The use of POCT for Ag test seems appropriate for SARS-CoV-2 screening in the pediatric population. In children, fever and gastrointestinal symptoms may constitute red flags of SARS-CoV-2.

WED 061 ‘real life’ experience with brivaracetam as add-on treatment for epilepsy

2018 ◽  
Vol 89 (10) ◽  
pp. A7.2-A7
Author(s):  
Hughes Rhiannon ◽  
Maguire Melissa ◽  
Geldard Jo ◽  
Reuber Markus
Keyword(s):  
Life Experience ◽  
Focal Epilepsy ◽  
Real Life ◽  
Service Evaluation ◽  
Serious Adverse Events ◽  
Daily Dose ◽  
History Of ◽  
The Mean ◽  
Clinical Records

BackgroundBrivaracetam received its UK licence as an adjuvant drug for focal epilepsy in adults in 2016. There is little data on its efficacy and tolerability in ‘real life’ settings. We present an interim analysis of a multicentre service evaluation of brivaracetam.MethodsData was retrospectively collected from clinical records at two UK centres of consecutive patients treated with brivaracetam and at least one follow up. Data were also extracted on previous levetiracetam use. Seizure frequency was categorised at baseline and follow-up (daily/weekly/monthly/yearly/none).Results: Of the 44 patients identified (17 male, mean age 39, range 19–66), 75% had a history of levetiracetam exposure (LE+) and 25% did not (LE−). Mean brivaracetam exposure was 10.3 months (2–21), the mean daily dose was 200 mg (50–400). Retention was 91% vs 100% in LE+ versus LE− groups at 3 months and 82% in both groups at 6 months. Seizure category improvements were seen in 20%/36.4% in the LE+ vs LE− groups, seizure category deteriorations in 0% vs 9%. There were no serious adverse events.ConclusionBrivaracetam emerges as a potentially useful adjuvant medication for focal epilepsy. It may be better tolerated by some patients than Levetiracetam and more effective than this drug.

scholarly journals The History of Conflict between Institutional and Native Hebrew in Israel

2020 ◽  
Vol 34 ◽  
pp. 9-35
Author(s):  
Uri Mor
Keyword(s):  
Formal Language ◽  
Life Experience ◽  
Native Speakers ◽  
Real Life ◽  
National Language ◽  
The Other ◽  
Popular Discourse ◽  
Generational Identity ◽  
History Of ◽  
The One

Contemporary popular discourse on Hebrew prescriptivism betrays an interesting ambivalence: acceptance of institutional standards on the one hand and objection to normative intervention on the other. This ambivalence can be traced to the tension between the Language Committee and the Palestine Teachers’ Association during the Second Aliyah. Both advocated that Israel adopt a modern national language, but the former was in favor of a systematic language planning, while the latter was in favor of spontaneous language adoption. In the 1950s, a similar tension developed between the older generation and the Sabras (native speakers), whose generational identity had crystallized during the pre-State period. The language promoted by the former group was an institutional variety bound to a prescriptive norm, while that promoted by the latter was a native variety bound to conventional norms and real-life experience. The tension in these two episodes led to a deep cultural rift—one that is familiar to every Hebrew speaker in Israel—between the formal language of the state and the natural language of Hebrew speakers. A crosslinguistic perspective reveals a resemblance between Israeli Hebrew and European Late Dialect Selection languages, suggesting that the ambivalence towards prescriptivism in fact indicates ambivalence towards the national language, which is perceived, simultaneously, as a manifestation of a stable national identity and an institutional interference in individual speech

scholarly journals Hipopara-Red, Real Life Experience in 322 Patients With Hypoparathyroidism

2020 ◽  
Vol 5 (2) ◽  
Author(s):  
María Belén Zanchetta ◽  
Damián Robbiani ◽  
Beatriz Oliveri ◽  
Evangelina Giacoia ◽  
Adriana Frigeri ◽  
...  
Keyword(s):  
Natural History ◽  
Clinical Management ◽  
Life Experience ◽  
Real Life ◽  
Clinical Complications ◽  
Common Causes ◽  
History Of ◽  
The Mean ◽  
Nonsurgical Patients

Abstract Context Hypoparathyroidism is a rare disease and, as such, its natural history, long-term complications, and correct clinical management remain unclear. Objective To describe the natural history and clinical characteristics of the disease. Design and Setting To present a retrospective observational analysis from 7 specialized centers in Buenos Aires, Argentina. Patients Chronic hypoparathyroid patients followed-up between 1985 and December 2018. Main Outcome Measures Data on demographics, etiology, clinical complications, biochemical parameters, dual-energy x-ray absorptiometry (DXA) values, and treatment doses were collected. Results A total of 322 subjects with chronic hypoparathyroidism were included; 85.7% were female, the mean age was 55.2 ± 16.8 years, and the mean age at diagnosis was 43.8 ± 16.8 years. Prevalence of surgical hypoparathyroidism was 90.7%, with the most common causes being thyroid carcinoma and benign thyroid disease. A history of hypocalcemia requiring hospitalization was present in 25.7% of the whole group and in 4.3% of patients who had a history of seizures. Overall, 40.9% of our patients had reported at least 1 neuromuscular symptom. Renal insufficiency was present in 22.4% of our patients and was significantly associated with age (P < 0.0001). Hyperphosphatemia was present in 42% of patients. A history of severe hypocalcemia, paresthesias, tetany, ganglia calcifications, seizures, and cataracts was significantly higher in nonsurgical patients. Conclusion Although these patients were followed-up by experienced physicians, clinical management was heterogeneous and probably insufficient to assess all the potential complications of this chronic disease. Almost 70% of the study’s group of patients met the experts’ indications for considering the use of rhPTH 1–84. Being aware of this fact is the 1st step in improving our medical management of this disease in the future.

scholarly journals How to Domesticate Otherness: Three Metaphors of Otherness in the European Cultural Tradition

Paideusis ◽  
2020 ◽  
Vol 16 (3) ◽  
pp. 33-43
Author(s):  
Robi Kroflic
Keyword(s):  
Life Experience ◽  
Real Life ◽  
Radical Change ◽  
The Other ◽  
Cultural Tradition ◽  
Collective Identities ◽  
Educational Processes ◽  
The Face ◽  
History Of ◽  
The Difference

Individual and collective identities always develop in relation to the other as different, and in this process, the otherness is always subjected to the attempts of cultivation/domestication. In the history of European thought, we can recognize three metaphors which express the impossibility of seeing the other as different: the metaphors of The Leper, The Court Fool and The Noble Savage. They developed on the basis of the relationship between the difference and common rationality, which means that a more inclusive relationship to otherness as a conversational ideal could be formed if we were able shift the emphasis of ethical discourse from the universal concept of autonomy to respect for authenticity and to Levinas’s ethics of “the face of the other”. Such a step requires a radical change of discursive practices of all involved in the educational processes. That is why I propose the principle of observing the face of the other as different in both real-life experience and in expressive images of art, as well as the recognition and acceptance of otherness at the very core of our own identity.

scholarly journals Psoriasis, biological drugs and Coronavirus Disease 2019: Real life experience of two Italian provinces

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Martina Vispi ◽  
Teresa Corradin ◽  
Camilla Peccianti ◽  
Luca Feci ◽  
Laura Casini ◽  
...  
Keyword(s):  
Life Experience ◽  
Close Contact ◽  
Real Life ◽  
World Health ◽  
Risk Category ◽  
Biological Drugs ◽  
Italian Provinces ◽  
The Media ◽  
Health Organization ◽  
Observation Period

On January 30, 2020, World Health Organization (WHO) stated that a new coronavirus disease outbreak [COronaVIrus Disease - 19 (COVID-19)] was an international public health emergency. Many news, often fake ones, about the derived pandemic rapidly spread along the media, thus leading many dermatological patients to identify as “risk category” and sometimes discontinue treatments by themselves. The Dermatology Units in Grosseto and Pordenone simultaneously carried out a data collection by remote-conducted visits, evaluating the incidence of COVID-19 in psoriatic patients. Only 1 patient (close contact of a case) as part of the psoriasis analyzed group was tested and turned out to be positive for SARS-CoV-2, developing no symptoms during the observation period. The collected information may suggest that psoriasis, biotechnologically treated or not, cannot promote or aggravate the clinical trend of the SARS-CoV-2 infection, hence stopping systemic therapy in negative or clinically free SARS-CoV-2 patients is not recommended in general.

scholarly journals The History of Conflict between Institutional and Native Hebrew in Israel

2020 ◽  
Vol 34 ◽  
pp. 9-35
Author(s):  
Uri Mor
Keyword(s):  
Formal Language ◽  
Life Experience ◽  
Native Speakers ◽  
Real Life ◽  
National Language ◽  
The Other ◽  
Popular Discourse ◽  
Generational Identity ◽  
History Of ◽  
The One

Contemporary popular discourse on Hebrew prescriptivism betrays an interesting ambivalence: acceptance of institutional standards on the one hand and objection to normative intervention on the other. This ambivalence can be traced to the tension between the Language Committee and the Palestine Teachers’ Association during the Second Aliyah. Both advocated that Israel adopt a modern national language, but the former was in favor of a systematic language planning, while the latter was in favor of spontaneous language adoption. In the 1950s, a similar tension developed between the older generation and the Sabras (native speakers), whose generational identity had crystallized during the pre-State period. The language promoted by the former group was an institutional variety bound to a prescriptive norm, while that promoted by the latter was a native variety bound to conventional norms and real-life experience. The tension in these two episodes led to a deep cultural rift—one that is familiar to every Hebrew speaker in Israel—between the formal language of the state and the natural language of Hebrew speakers. A crosslinguistic perspective reveals a resemblance between Israeli Hebrew and European Late Dialect Selection languages, suggesting that the ambivalence towards prescriptivism in fact indicates ambivalence towards the national language, which is perceived, simultaneously, as a manifestation of a stable national identity and an institutional interference in individual speech.

The space of V.S. Naipaul’s novels in the light of multicultural theory

2021 ◽  
Vol 66 (1) ◽  
pp. 26-33
Author(s):  
Le Dinh Thi
Keyword(s):  
Trinidad And Tobago ◽  
Life Experience ◽  
Real Life ◽  
Cultural Space ◽  
Spatial Dimensions ◽  
History Of ◽  
The Relationship ◽  
Place And Identity ◽  
Insight Into ◽  
Multicultural Theory

It is a self-evident truth that V.S. Naipaul 's novels hold powerful appeal to readers worldwide thanks to his real-life experience of migration and changes in psychology and lifestyles between multicultural spaces. The writer has successfully created a diversified, rich, traditional hybrid space of the Trinidad and Tobago, an African cultural space before the historical upheavals, and English villages and towns after the the golden age of wealthy nobles and landowners. Studying these spatial dimensions through the prisms of Doreen Massey's multicultural theory will offer an insight into the relationship between place and identity, as well as the artistic talent of V.S. Naipaul, a passionate and gifted writer, who devoted his life to “the history of oppressed peoples”, contributing a great voice to “marginal” cultures.

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