Bone Marrow Necrosis in Acute Lymphoblastic Leukaemia

1987 ◽  
Vol 32 (6) ◽  
pp. 177-180 ◽  
Author(s):  
H.W. Habboush ◽  
I.M. Hann
Keyword(s):  
Bone Marrow ◽  
Complete Remission ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Bone Marrow Necrosis ◽  
Prognostic Features ◽  
Remission Duration ◽  
Prognostic Feature ◽  
Poor Prognostic Feature ◽  
Low Rate

Bone marrow necrosis, an uncommon finding in acute lymphoblastic leukaemia, has previously been regarded as a poor prognostic feature. It has been associated with difficulty in establishing the diagnosis, a low rate of remission as well as short remission duration. We report a case of bone marrow necrosis in a girl with acute lymphoblastic leukaemia and good prognostic features who attained complete remission uneventfully and will discuss previous reports of this association in the literature.

scholarly journals Extensive Bone Marrow Necrosis: A Rare Presentation of Acute Lymphoblastic Leukaemia

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
I. Ranathunga ◽  
N. R. Muthumala ◽  
H. W. C. K. Kulathilake ◽  
S. Weerasinghe ◽  
N. L. A. Shyamali
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Bone Marrow Aspiration ◽  
Blood Film ◽  
Lymphoid Cells ◽  
Severe Neutropenia ◽  
Bone Marrow Necrosis ◽  
Rare Presentation ◽  
Extensive Necrosis

Background. Bone marrow necrosis (BMN) is a rare entity which presents with bone pain, fever, and peripheral cytopenia. Acute lymphoblastic leukaemia (ALL) is characterized by malignant proliferation of immature lymphocytes, and patients usually present with fatigue and bleeding manifestations. Presentation with BMN is an extremely rare finding and only few cases had been reported in the literature. Case Presentation. A 22-year-old male presented with nocturnal lower back ache, pleuritic central chest pain, and fever for two weeks. He was extensively investigated for a cause. His investigations revealed pancytopenia with severe neutropenia. Initial bone marrow aspiration and biopsy did not provide a positive result due to extensive necrosis. However, immunohistochemical analysis of few immature lymphoid cells on repeated BM biopsy showed evidence of acute lymphoblastic leukaemia. Conclusions. ALL usually presents with fatigue and bleeding manifestations. Presentation with BMN is extremely rare. The diagnosis was extremely challenging as this patient had only occasional atypical cells in the peripheral blood film and the repeat bone marrow (BM) biopsy showed extensive necrosis.

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