Comments in response to report on ‘Late reversal reaction with resistant Mycobacterium leprae: an emerging paradigm’

2020 ◽  
Vol 50 (4) ◽  
pp. 395-396
Author(s):  
Tarun Narang ◽  
Divya Kamat ◽  
Sunil Dogra ◽  
Bhushan Kumar
Keyword(s):  
Mycobacterium Leprae ◽  
Reversal Reaction

scholarly journals Glucocorticoids in Leprosy Reversal reaction

2019 ◽  
Vol 11 (3) ◽  
pp. 77-83
Author(s):  
Renni Yuniati ◽  
Matthew Brian Khrisna
Keyword(s):  
Corticosteroid Therapy ◽  
Mycobacterium Leprae ◽  
Alternative Therapies ◽  
Reaction Type ◽  
Therapy Regimen ◽  
Key Points ◽  
Who Guideline ◽  
Reversal Reaction

Abstract Leprosy is a disease that is caused by Mycobacterium leprae which results in lots of disabilities in the patients. Leprosy is treated by multi-drug therapy regimen; however, this therapy might cause leprosy reactions in the patients. There are several types of lepromatous reaction: type 1 reaction, type 2 reaction and neuritis. Type 1 reaction mainly occurs in BB, BL and BT forms of leprosy and is characterized by exacerbation of preexisting lesions. The therapy of this reaction according to the WHO guideline is corticosteroid therapy. This article will explain several key points related to the corticosteroid therapy in leprosy reversal reactions, including the side effects and alternative therapies available.

scholarly journals Late reversal reaction with resistant Mycobacterium leprae: an emerging paradigm

2019 ◽  
Vol 50 (1) ◽  
pp. 77-81 ◽  
Author(s):  
Kabir Sardana ◽  
Sinu Rose Mathachan ◽  
Diksha Agrawal ◽  
Mallika Lavania ◽  
Madhvi Ahuja
Keyword(s):  
Mycobacterium Leprae ◽  
Reversal Reaction

scholarly journals Early diagnosis of relapse in borderline leprosy: two case reports

2011 ◽  
Vol 53 (6) ◽  
pp. 341-343 ◽  
Author(s):  
Maria Luiza Figueiredo Braga Brandão ◽  
Cíntia Maria Oliveira Lima ◽  
Juan Piñeiro-Maceira ◽  
Alice Miranda ◽  
M.Leide W. de Oliveira
Keyword(s):  
Drug Therapy ◽  
Early Diagnosis ◽  
Case Reports ◽  
Mycobacterium Leprae ◽  
Skin Lesions ◽  
One Year ◽  
Reversal Reaction

Two cases of relapse in borderline leprosy were reported. Despite the late-reversal, reaction-like feature, the suspicion of relapse in both was based on persistent and slow-developing skin lesions and an absence of acute neuritis or reaction during one year of follow-up. The authors have considered this possible occurrence in lepromatous borderline-treated patients after their immune cellular restoration and defend that not all Type 1 reactions would be an inflammatory answer to persistent Mycobacterium leprae, but that they could be. Therefore, a relapse diagnosis could be applied and it is more advisable, as one year of Multi-Drug Therapy (MDT) is less dangerous and more efficient for these cases than one year of corticosteroids.

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