Indications of Goal Displacement in Regulatory Enforcement Agencies: An Empirical Exploration

2021 ◽  
pp. 009539972110657
Author(s):  
Kees Huizinga
Keyword(s):  
Regulatory Enforcement ◽  
Goal Alignment ◽  
Organizational Reform ◽  
Regulatory Domains ◽  
Systematic Exploration ◽  
Goal Displacement

This paper describes indications of goal displacement in regulatory enforcement agencies as reported by enforcement professionals from a range of regulatory domains. The findings suggest that the occurrence of this phenomenon in these agencies may be more prevalent and multifaceted than expected. Among the goal-displacement types reported as most impactful were goal narrowing, induced by calamities, goal diversion through ongoing organizational reform, and goal diversion brought upon by strict regimes of output management. A systematic exploration of these various goal-displacement types as conducted here sheds light onto the intricate nature of goal alignment of these agencies.

Discovery of a Difluoroglycine Synthesis Method through Quantum Chemical Calculations

2020 ◽  
Author(s):  
Tsuyoshi Mita ◽  
Yu Harabuchi ◽  
Satoshi Maeda
Keyword(s):  
Quantum Chemical Calculations ◽  
Experimental Verification ◽  
Quantum Chemical ◽  
Synthesis Method ◽  
Target Product ◽  
Systematic Exploration ◽  
Hands On ◽  
Retrosynthetic Analysis ◽  
Synthetic Routes ◽  
Verification Process

The systematic exploration of synthetic pathways to afford a desired product through quantum chemical calculations remains a considerable challenge. In 2013, Maeda et al. introduced ‘quantum chemistry aided retrosynthetic analysis’ (QCaRA), which uses quantum chemical calculations to search systematically for decomposition paths of the target product and propose a synthesis method. However, until now, no new reactions suggested by QCaRA have been reported to lead to experimental discoveries. Using a difluoroglycine derivative as a target, this study investigated the ability of QCaRA to suggest various synthetic paths to the target without relying on previous data or the knowledge and experience of chemists. Furthermore, experimental verification of the seemingly most promising path led to the discovery of a synthesis method for the difluoroglycine derivative. The extent of the hands-on expertise of chemists required during the verification process was also evaluated. These insights are expected to advance the applicability of QCaRA to the discovery of viable experimental synthetic routes.

Discovery of a Difluoroglycine Synthesis Method through Quantum Chemical Calculations

2020 ◽  
Author(s):  
Tsuyoshi Mita ◽  
Yu Harabuchi ◽  
Satoshi Maeda
Keyword(s):  
Quantum Chemical Calculations ◽  
Experimental Verification ◽  
Quantum Chemical ◽  
Synthesis Method ◽  
Target Product ◽  
Systematic Exploration ◽  
Hands On ◽  
Retrosynthetic Analysis ◽  
Synthetic Routes ◽  
Verification Process

The systematic exploration of synthetic pathways to afford a desired product through quantum chemical calculations remains a considerable challenge. In 2013, Maeda et al. introduced ‘quantum chemistry aided retrosynthetic analysis’ (QCaRA), which uses quantum chemical calculations to search systematically for decomposition paths of the target product and propose a synthesis method. However, until now, no new reactions suggested by QCaRA have been reported to lead to experimental discoveries. Using a difluoroglycine derivative as a target, this study investigated the ability of QCaRA to suggest various synthetic paths to the target without relying on previous data or the knowledge and experience of chemists. Furthermore, experimental verification of the seemingly most promising path led to the discovery of a synthesis method for the difluoroglycine derivative. The extent of the hands-on expertise of chemists required during the verification process was also evaluated. These insights are expected to advance the applicability of QCaRA to the discovery of viable experimental synthetic routes.

In Conclusion

2018 ◽  
Author(s):  
Jaime Kucinskas
Keyword(s):  
Environmental Protection ◽  
Social Institutions ◽  
Contemplative Practices ◽  
Organizational Reform ◽  
Women's Equality ◽  
Lgbtq Rights

The mindfulness movement’s unobtrusive, consensus-based tactics were effective in popularizing, embedding, and legitimizing contemplative practices in a wide array of powerful social institutions. Yet, using consensus-based tactics and relying upon elite endorsements and support also opened the movement up to criticisms of potential cooptation along many fronts. Although movement leaders succeeded in changing the minds and hearts of many professionals, the movement as a whole failed to produce desired organizational reform. This concluding chapter discusses these implications of these tactics’ strengths and shortcomings not only for the contemplative movement but for other similar movements trying to change institutions through insiders working within and across targeted organizations and movements. These include the movements for LGBTQ rights, women’s equality, and environmental protection.

Systematic exploration of quaternary ammonium salt adsorption on oxidized coal based on experiments and MD simulations

Fuel ◽  
2021 ◽  
Vol 287 ◽  
pp. 119434
Author(s):  
Jun Chen ◽  
Hongliang Li ◽  
Chunfu Liu ◽  
Lingyun Liu ◽  
Yu Sun ◽  
...  
Keyword(s):  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
Md Simulations ◽  
Oxidized Coal ◽  
Systematic Exploration
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