scholarly journals Otomycosis in Immunocompetent and Immunocompromised Patients: Comparative Study and Literature Review

2012 ◽  
Vol 91 (3) ◽  
pp. 114-121 ◽  
Author(s):  
Borlingegowda Viswanatha ◽  
Dadarao Sumatha ◽  
Maliyappanahalli Siddappa Vijayashree
Keyword(s):  
Candida Albicans ◽  
Clinical Study ◽  
Clinical Presentation ◽  
Tympanic Membrane Perforation ◽  
Immunocompromised Patients ◽  
Bilateral Involvement ◽  
Membrane Perforation ◽  
Comparative Clinical Study ◽  
Ear Drops ◽  
Immunocompetent Patients

A comparative clinical study was carried out that included 50 cases of otomycosis in immunocompetent patients and 50 cases of otomycosis in immunocompromised patients. Clinical presentation, predisposing factors, mycologic profile, and treatment outcomes were compared. Aspergillus spp were the most commonly isolated fungi in the immunocompetent group, and Candida albicans in the immunocompromised group. Bilateral involvement was more common in the immunocompromised group. All the patients were treated with topical clotrimazole ear drops. Four patients in the immunocompromised group did not respond to treatment with clotrimazole but were treated successfully with fluconazole ear drops. Three patients had a small tympanic membrane perforation due to otomycosis.

Ototoxicity after use of neomycin eardrops is unrelated to A1555G point mutation in mitochondrial DNA

2004 ◽  
Vol 118 (7) ◽  
pp. 546-550 ◽  
Author(s):  
Tatsuya Yamasoba ◽  
Katsunori Tsukuda
Keyword(s):  
Mitochondrial Dna ◽  
Tympanic Membrane ◽  
Point Mutation ◽  
Middle Ear ◽  
Dna Analysis ◽  
Tympanic Membrane Perforation ◽  
Mitochondrial Dna Analysis ◽  
Membrane Perforation ◽  
Inner Ear Damage ◽  
Ear Drops

Ear drops containing neomycin only rarely cause ototoxicity. The authors report on three patients with a tympanic membrane perforation who developed severe ototoxicity after use of eardrops containing 0.35 per cent neomycin. Mitochondrial DNA analysis revealed that there was no A1555G point mutation in these patients. This finding indicates that application of low concentration neomycin to the middle ear can cause severe inner ear damage even in humans who are not hyper-susceptible to aminoglycosides.

Topical Therapeutics for Otitis Media

1981 ◽  
Vol 89 (3) ◽  
pp. 381-385 ◽  
Author(s):  
David N.F. Fairbanks
Keyword(s):  
Bacterial Contamination ◽  
Topical Therapy ◽  
Tympanic Membrane Perforation ◽  
Definitive Treatment ◽  
Intracranial Extension ◽  
Membrane Perforation ◽  
Aerobic And Anaerobic ◽  
Ear Drops ◽  
Middle Ear Cleft ◽  
Antiseptic Solutions

In chronic draining ear associated with a tympanic membrane perforation, cholesteatoma, or both, the infection is that of bacterial contamination. Both aerobic and anaerobic organisms are found, notably Pseudomonas, staphylococcus, and enteric organisms, particularly bacteroides. The disease exists because of a structural defect in the middle ear cleft, which requires surgery as definitive treatment. Medical therapy is valuable as a temporary measure in preoperative preparation, and in prevention and management of intracranial extension. Topical therapy with antibiotic ear drops is often helpful, but also important is local care with cleansing, drying, and antiseptic solutions or powders. Therapy is usually directed toward the Pseudomonas organisms with aminoglycoside-polymyxin combination otic drops. However, Bacteroides fragilis now looms as an important pathogen in 13% of affected patients. Chloramphenicol otic drops are indicated when such an infection is suspected or identified.

R436 – Association Between Chronic Otitis Media and Otosclerosis

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P190-P190
Author(s):  
Sebahattin Cureoglu ◽  
Nomiya Rie ◽  
Nomiya Shigenobu ◽  
Schachern Patricia ◽  
Norimasa Morita ◽  
...  
Keyword(s):  
Clinical Study ◽  
Tympanic Membrane ◽  
Otitis Media ◽  
Chronic Otitis Media ◽  
Tympanic Membrane Perforation ◽  
Membrane Perforation ◽  
Temporal Bones ◽  
Previous Clinical Study

Problem In a previous clinical study, the incidence of chronic otitis media in cases of otosclerosis was reported to be less than that observed in patients without otosclerosis. Histopathologically, we can detect minimal changes such as histological otosclerosis or silent otitis media which are not detected clinically. The purpose of this study is to reveal the association of otosclerosis and chronic otitis media by evaluating human temporal bones, histopathologically. Methods 1235 human temporal bones were reviewed for this study. In order to match patients with otosclerosis, patients with chronic otitis media were limited to 16 to 92 years of age. The incidence of otosclerosis (clinical otosclerosis, histological otosclerosis) and chronic otitis media, either clinical (tympanic membrane perforation) or silent (without perforation) were analyzed. Results There was no statistically difference between the incidence of chronic otitis media in temporal bones with and without otosclerosis. Conclusion The association of chronic otitis media and otosclerosis appears to be a coincidental. Significance The incidence of chronic otitis media in cases of otosclerosis is not less than that observed in cases of chronic otitis media in cases without otosclerosis. Support International Hearing Foundation, Hubbard Foundation, Starkey Foundation.

scholarly journals A Clinical Study of Traumatic Tympanic Membrane Perforation

2010 ◽  
Vol 113 (8) ◽  
pp. 679-686 ◽  
Author(s):  
Kazuharu Yamazaki ◽  
Ken Ishijima ◽  
Hiroaki Sato
Keyword(s):  
Clinical Study ◽  
Tympanic Membrane ◽  
Tympanic Membrane Perforation ◽  
Membrane Perforation

scholarly journals Effectiveness of oral itraconazole in the management of otomycosis with tympanic membrane perforation

2017 ◽  
Vol 5 (4) ◽  
pp. 1373 ◽  
Author(s):  
Aju Ravindran ◽  
Sagesh M.
Keyword(s):  
Tympanic Membrane ◽  
Treatment Response ◽  
Difficult Problem ◽  
Tympanic Membrane Perforation ◽  
Prolonged Treatment ◽  
Membrane Perforation ◽  
Oral Itraconazole ◽  
Methods Of Treatment ◽  
Perforated Tympanic Membrane ◽  
Ear Drops

Background: Otomycosis can be a difficult problem to treat in a patient who already has a perforation of the tympanic membrane. This study highlights the effectiveness of oral Itraconazole in treating such cases.Methods: Thirty-four patients with otomycosis and a perforated tympanic membrane were included in the study and were treated with oral itraconazole and antibiotic ear drops. They were followed up for six weeks to look for treatment response and any recurrence.Results: Of the 34 patients in the study, 25 patients were fully cured with one week of oral Itraconazole therapy. Six out of the remaining 9 patients were cured of the disease with two weeks’ therapy. Three patients needed prolonged treatment and one patient had a recurrence at six weeks.Conclusions: Oral itraconazole therapy is an effective alternative to the traditional methods of treatment for otomycosis with tympanic membrane perforation.

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