Immediate effects of individualized heparin and protamine management on hemostatic activation and platelet function in adult patients undergoing cardiac surgery with tranexamic acid antifibrinolytic therapy

Perfusion ◽  
2013 ◽  
Vol 28 (5) ◽  
pp. 412-418 ◽  
Author(s):  
B Hofmann ◽  
H Bushnaq ◽  
FB Kraus ◽  
C Raspé ◽  
A Simm ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Tranexamic Acid ◽  
Platelet Function ◽  
Adult Patients ◽  
Antifibrinolytic Therapy

The Influence of Aprotinin and Tranexamic Acid on Platelet Function and Postoperative Blood Loss in Cardiac Surgery

2008 ◽  
Vol 107 (2) ◽  
pp. 391-397 ◽  
Author(s):  
Andinet M. Mengistu ◽  
Kerstin D. Röhm ◽  
Joachim Boldt ◽  
Jochen Mayer ◽  
Stefan W. Suttner ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Platelet Function ◽  
Postoperative Blood Loss

Preservation of collagen-induced whole blood platelet aggregation by tranexamic acid therapy in primary cardiac valve surgery

Perfusion ◽  
2000 ◽  
Vol 15 (6) ◽  
pp. 507-513 ◽  
Author(s):  
Tetsuya Miyashita ◽  
Takahiko Kamibayashi ◽  
Yoshihiko Ohnishi ◽  
Junjiro Kobayashi ◽  
Masakazu Kuro
Keyword(s):  
Cardiac Surgery ◽  
Platelet Aggregation ◽  
Tranexamic Acid ◽  
Platelet Function ◽  
Whole Blood ◽  
Blood Platelet ◽  
Acid Group ◽  
Valve Surgery ◽  
Control Group ◽  
Blood Platelet Aggregation

Haemostatic disorder is one of the most common complications following cardiac surgery with cardiopulmonary bypass (CPB). Tranexamic acid reduces blood loss and allogeneic blood transfusion requirement in cardiac surgery. It had been thought that tranexamic acid inhibited fibrinolysis alone following CPB. In the present study, the haemostatic effects of tranexamic acid (20 mg/kg body weight bolus after induction of anaesthesia followed by continuous infusion at 2 mg/kg/h), including fibrinolysis and platelet function, were investigated in 22 patients (tranexamic acid group n = 12; control group n = 10) undergoing primary cardiac valve surgery. Fibrinolysis following CPB was reduced significantly in the tranexamic acid group. Following protamine administration, the reduction of collagen-induced whole blood platelet aggregation was mitigated significantly in the tranexamic acid group compared with the control group (36% reduction in the tranexamic acid group vs 58% in the control group; p = 0.011), although platelet counts did not differ between the two groups. In conclusion, tranexamic acid not only inhibits fibrinolysis directly, but also may preserve platelet function following CPB.

Antifibrinolytic Therapy for Cardiac Surgery

2015 ◽  
Vol 123 (1) ◽  
pp. 214-221 ◽  
Author(s):  
Andreas Koster ◽  
David Faraoni ◽  
Jerrold H. Levy
Keyword(s):  
Cardiac Surgery ◽  
Side Effects ◽  
Tranexamic Acid ◽  
Chest Tube ◽  
Surgical Patients ◽  
Two Phase ◽  
Adverse Side Effects ◽  
Antifibrinolytic Therapy ◽  
Phase Ii Studies ◽  
New Compounds

Abstract Antifibrinolytic therapy reduces bleeding and chest tube drainage output in cardiac surgical patients but is associated with potential side effects. Two phase-II studies with new compounds were terminated prematurely. There is increasing evidence of adverse side effects with tranexamic acid.

Comparison of Tranexamic-Acid and Aprotinin regarding the outcome after cardiac surgery

2011 ◽  
Vol 59 (S 01) ◽  
Author(s):  
A Cetinkaya ◽  
A Van Linden ◽  
Z Szalay ◽  
A Afflerbach ◽  
J Blumenstein ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Tranexamic Acid
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