Major depressive disorder with psychotic features induced by                 interferon-α treatment for hepatitis C in a polydrug abuser

ABSTRACT BACKGROUND: Major depressive disorder (MDD) is commonly reported in patients with chronic hepatitis C (CHC); however, the factors behind the co-occurrence of these conditions have not been completely clarified yet. OBJECTIVE: We aimed to evaluate the frequency of mental disorders in CHC patients and to investigate variables associated with MDD. METHODS: CHC patients (n=151) attending a referral Centre for hepatitis were evaluated using the Mini-International Neuropsychiatry Interview and the Cut-Annoyed-Guilty-Eye (CAGE) Questionnaire. Multivariate analysis was used to evaluate independent covariates associated with current MDD. RESULTS: Seventy-six (50.3%) patients had, at least, one current psychiatric diagnosis with MDD (33.1%) being the most common. Current MDD was independently associated with age (≤50 yr.) (OR=2.57; 95%CI=1.25-5.29; P=0.01) and type 2 diabetes mellitus (OR=2.80, 95%CI=1.17-6.70; P=0.02). Cirrhosis was associated with type 2 diabetes mellitus (OR=5.09; 95%CI=1.73-15.04; P=0.03) and current alcohol abuse/dependence (OR=2.54; 95%CI=1.04-6.22; P=0.04). DISCUSSION: MDD is associated with type 2 diabetes in CHC patients. Even in the direct-acting antivirals (DAAs) era, characterized by great perspectives for the first ample cure of a chronic viral infection, we should ensure that the screening for psychiatric disorders takes place in the course of routine clinical care of patients chronically infected with hepatitis C virus.

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Ziprasidone in the treatment of major depressive disorder with psychotic features

Pharmacopsychiatry ◽

10.1055/s-2005-918784 ◽

2005 ◽

Vol 38 (05) ◽

Author(s):

O Möller ◽

DH Nguyen ◽

U Dannlowski ◽

J Deckert ◽

V Arolt ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Major Depressive ◽

Psychotic Features

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A Case Series: Adjunctive Treatment of Major Depressive Disorder in the Geriatric Population with the Methylphenidate Patch

Case Reports in Psychiatry ◽

10.1155/2019/2890913 ◽

2019 ◽

Vol 2019 ◽

pp. 1-3

Author(s):

Kamal Patel ◽

Ashley Collins ◽

Suzanne Holroyd ◽

Andre Benja Lamyaithong

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Elderly Patients ◽

Initial Treatment ◽

Geriatric Patients ◽

Case Series ◽

Adjunctive Treatment ◽

Major Depressive ◽

Geriatric Population ◽

Psychotic Features

Major depressive disorder can affect anyone regardless of age. In geriatric populations depression is often overlooked and untreated, which subsequently may lead to serious consequences. Almost one third of elderly patients with depression fail to respond to initial treatment and require adjunctive treatment. Methylphenidate is one such option, which is seldom used in the geriatric population to treat depression despite reports of improvement in symptoms of mood within a brief period of time. Methylphenidate is also available in a patch formulation that can be used in patient’s nonadherent to the medication, which is reported to be an issue in as many as 75% of the geriatric population. Here we present three geriatric patients who were diagnosed with recurrent severe major depressive disorder without psychotic features. The three patients responded well with methylphenidate as adjunctive treatment to conventional antidepressants.

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