scholarly journals Acute sleep deprivation: the effects of the AMPAKINE compound CX717 on human cognitive performance, alertness and recovery sleep

2011 ◽  
Vol 26 (8) ◽  
pp. 1047-1057 ◽  
Author(s):  
Julia Boyle ◽  
Neil Stanley ◽  
Lynette M James ◽  
Nicola Wright ◽  
Sigurd Johnsen ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Recovery Sleep ◽  
Acute Sleep Deprivation

123 Detrimental effects of acute sleep deprivation on perceptual metacognition

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A50-A50
Author(s):  
Marco Bigica ◽  
Chunxiang Jiang ◽  
Ilenia D’Onofrio ◽  
Zhishan Liu ◽  
Chen Song
Keyword(s):  
Sleep Deprivation ◽  
Executive Functions ◽  
Cognitive Performance ◽  
Orientation Discrimination ◽  
Perceptual Decision ◽  
Recovery Sleep ◽  
Acute Sleep Deprivation ◽  
Flicker Fusion ◽  
Perceptual Threshold ◽  
Metacognitive Accuracy

Abstract Introduction Sleep deprivation (SD) impairs cognitive performance but its impact on metacognition – i.e. the ability to introspect about cognitive performance – is less clear. A few studies have assessed metacognitive accuracy after acute sleep deprivation in tasks of executive functions and found no impairments. However, whether SD has no influence on metacognition of other cognitive domains such as perception has not been investigated. In this study, we examined how metacognitive accuracy in perceptual decision tasks is affected by 32 hours of sustained wakefulness. Methods 14 participants (3 males, aged 20-32) repeated four visual psychophysical tasks (orientation discrimination, two-flicker fusion, vernier acuity and a novel face/house discrimination in noise) at regular intervals during 32 hours of sustained wakefulness and once after 8 hours recovery sleep. In each task, we concurrently measured quantitative indices of perceptual threshold, confidence rating and metacognitive accuracy (i.e. how well confidence ratings discriminate correct vs incorrect perceptual judgements). Results We observed a gradual increase of perceptual threshold in all tasks with increased time awake. Furthermore, metacognitive accuracy gradually decreased during sustained wakefulness in all tasks. Specifically, the decrease in metacognitive accuracy was driven by over-estimated confidence in trials when participants made incorrect perceptual judgements. After recovery sleep, perceptual thresholds were reset to baseline for all tasks, while metacognitive accuracy was reset to baseline for the orientation discrimination and two-flicker fusion tasks only. Conclusion We showed that sustained wakefulness up to 32 hours increasingly impairs metacognitive accuracy in perceptual decision tasks. These results are consistent across different perceptual tasks, but are in contrast to previous studies showing preserved metacognition of executive functions after SD. Overall, this suggests that the fundamental mechanisms of perceptual metacognition may be similarly affected by sleep deprivation, but that SD selectively impacts different domains of metacognition, such as perceptual metacognition and metacognition of executive functions. Support (if any) MB - Cardiff University PhD Funding CS - Wellcome Trust 209192/Z/17/Z

Could BDNF be involved in compensatory mechanisms to maintain cognitive performance despite acute sleep deprivation? An exploratory study

2016 ◽  
Vol 99 ◽  
pp. 96-102 ◽  
Author(s):  
Bruno Lima Giacobbo ◽  
Márcio Silveira Corrêa ◽  
Kelem Vedovelli ◽  
Carlos Eduardo Bruhn de Souza ◽  
Letícia Martins Spitza ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Exploratory Study ◽  
Compensatory Mechanisms ◽  
Acute Sleep Deprivation

044 Slow oscillatory transcranial direct current stimulation enhances cognitive performance during subsequent sleep deprivation

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A19-A19
Author(s):  
John Hughes ◽  
Tracy Jill Doty ◽  
Ruthie Ratcliffe ◽  
Thomas Balkin
Keyword(s):  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Slow Oscillation ◽  
Physiological Basis ◽  
Medicine Research ◽  
Direct Current Stimulation ◽  
Psychomotor Vigilance Test ◽  
Recovery Sleep

Abstract Introduction The EEG slow oscillation of < 1 Hertz frequency has been implicated in various sleep functions, sparking a recent interest in slow oscillation enhancement strategies. In a seminal study, Marshall et al. (2006) demonstrated that 25 minutes of a slow oscillatory form of transcranial direct current stimulation (SO-tDCS) during early nocturnal sleep improved subsequent retention of word pairs learned prior to sleep, consistent with a proposed role for the slow oscillation in sleep-related memory consolidation. Another proposed function of the slow oscillation is synaptic downscaling, hypothesized to constitute the physiological basis for satisfying the homeostatic drive for sleep, per the synaptic homeostasis hypothesis of Tononi and Cirelli. We sought to determine if SO-tDCS could enhance the restorative properties of sleep, by enhancing slow oscillation activity, during a restricted sleep opportunity by assessing performance during a subsequent period of sleep deprivation (SD). Methods Twenty-six healthy volunteers were randomized into two groups. Participants either received electrical stimulation with 50 minutes of SO-tDCS at 0.75Hz, or sham stimulation, during the second hour of a restricted two hour sleep opportunity (11:00PM TO 1:00AM), followed by a 46 hour period of SD and then two recovery nights of sleep. Vigilance was assessed periodically with the Psychomotor Vigilance Test (PVT) during a baseline day, SD, and during the two days following recovery sleep nights. Results A mixed linear regression revealed significant main effects of day, group, and the interaction between group and day on mean reaction time (RT). Posthoc analysis revealed faster RTs following stimulation on day 2 of SD. It was also found that participants in the stimulation group had fewer major lapses (RTs > 500 ms) than those in the sham group over the first three days following stimulation. Conclusion Slow oscillatory transcranial direct current stimulation during a portion of a restricted period of sleep appears to enhance sleep’s restorative properties and improves cognitive performance during subsequent sustained wakefulness. The mechanistic basis for this phenomenon may be increased slow oscillation induced synaptic renormalization. Support (if any) Department of Defense Military Operational Medicine Research Program (MOMRP)

scholarly journals Effects of Sleep Deprivation on Brain Bioenergetics, Sleep, and Cognitive Performance in Cocaine-Dependent Individuals

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
George H. Trksak ◽  
Bethany K. Bracken ◽  
J. Eric Jensen ◽  
David T. Plante ◽  
David M. Penetar ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Sleep Loss ◽  
Continuous Performance ◽  
Digit Symbol ◽  
Continuous Performance Task ◽  
Performance Task ◽  
Recovery Sleep ◽  
Symbol Substitution ◽  
Healthy Control

In cocaine-dependent individuals, sleep is disturbed during cocaine use and abstinence, highlighting the importance of examining the behavioral and homeostatic response to acute sleep loss in these individuals. The current study was designed to identify a differential effect of sleep deprivation on brain bioenergetics, cognitive performance, and sleep between cocaine-dependent and healthy control participants. 14 healthy control and 8 cocaine-dependent participants experienced consecutive nights of baseline, total sleep deprivation, and recovery sleep in the research laboratory. Participants underwent[31]P magnetic resonance spectroscopy (MRS) brain imaging, polysomnography, Continuous Performance Task, and Digit Symbol Substitution Task. Following recovery sleep,[31]P MRS scans revealed that cocaine-dependent participants exhibited elevated global brainβ-NTP (direct measure of adenosine triphosphate),α-NTP, and total NTP levels compared to those of healthy controls. Cocaine-dependent participants performed worse on the Continuous Performance Task and Digit Symbol Substitution Task at baseline compared to healthy control participants, but sleep deprivation did not worsen cognitive performance in either group. Enhancements of brain ATP levels in cocaine dependent participants following recovery sleep may reflect a greater impact of sleep deprivation on sleep homeostasis, which may highlight the importance of monitoring sleep during abstinence and the potential influence of sleep loss in drug relapse.

scholarly journals Altered hippocampal transcriptome dynamics following sleep deprivation

2021 ◽  
Author(s):  
Marie E Gaine ◽  
Ethan Bahl ◽  
Snehajyoti Chatterjee ◽  
Jacob J Michaelson ◽  
Ted Abel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sleep Deprivation ◽  
Rna Splicing ◽  
Public Health Problem ◽  
The United States ◽  
Postsynaptic Membrane ◽  
Protein Coding ◽  
Recovery Sleep ◽  
Behavioral Studies ◽  
Acute Sleep Deprivation

Widespread sleep deprivation is a continuing public health problem in the United States and worldwide affecting adolescents and adults. Acute sleep deprivation results in decrements in spatial memory and cognitive impairments. The hippocampus is vulnerable to acute sleep deprivation with changes in gene expression, cell signaling, and protein synthesis. Sleep deprivation also has long lasting effects on memory and performance that persist after recovery sleep, as seen in behavioral studies from invertebrates to humans. Although previous research has shown that acute sleep deprivation impacts gene expression, the extent to which sleep deprivation affects gene regulation remains unknown. Using an unbiased deep RNA sequencing approach, we investigated the effects of acute sleep deprivation on gene expression in the hippocampus. We identified 1,146 genes that were significantly dysregulated following sleep deprivation with 507 genes upregulated and 639 genes downregulated, including protein coding genes and long non-coding RNAs not previously identified as impacted by sleep deprivation. Notably, genes significantly upregulated after sleep deprivation were associated with RNA splicing and the nucleus. In contrast, downregulated genes were associated with cell adhesion, dendritic localization, the synapse, and postsynaptic membrane. These results clearly demonstrate that sleep deprivation differentially regulates gene expression on multiple transcriptomic levels to impact hippocampal function.

scholarly journals 0041 Heart Rate Variability Differs in Resilient vs. Vulnerable Adults from Total Sleep Deprivation and Psychological Stress and Predicts Cognitive Performance

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A16-A17
Author(s):  
E M Yamazaki ◽  
K M Rosendahl-Garcia ◽  
L E MacMullen ◽  
A J Ecker ◽  
J N Kirkpatrick ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Individual Differences ◽  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Psychological Stress ◽  
Total Sleep Deprivation ◽  
Time Points ◽  
Significant Time ◽  
Recovery Sleep

Abstract Introduction There are substantial individual differences (resilience and vulnerability) in neurobehavioral performance from psychosocial stress and sleep loss. However, the time course of heart rate variability (HRV) across baseline, total sleep deprivation (TSD), the combination of TSD + psychological stress, and recovery has not been investigated; in addition, it remains unknown whether HRV and blood pressure (BP) differ in resilient vs. vulnerable individuals and predict individual differences in cognitive performance. Methods Thirty-one healthy adults (ages 27–53; mean±SD, 35.4±7.1y; 14 females) participated in a five-day experiment consisting of two 8h time-in-bed (TIB) baseline nights, 39h TSD, and two 8h-10h TIB recovery nights. A modified Trier Social Stress Test (TSST) induced psychological stress on the TSD day. Systolic and diastolic BP and HRV (derived from echocardiographic R-R interval) were obtained at six time points (pre-study, baseline, during TSD, during TSD after the TSST, after recovery, and post-study). Cognitively resilient (n=15) and vulnerable (n=16) groups were defined by a median split on 10-minute Psychomotor Vigilance Test (PVT) TSD performance [total lapses (>500ms response time) and errors]. Repeated measures ANOVA and post-hoc comparisons corrected for multiple testing, examined BP and HRV across time points between groups. Results HRV showed a significant time*group interaction: while resilient individuals had significantly lower HRV at pre-study compared to vulnerable individuals, their HRV increased above that of vulnerable individuals with TSD and with TSD + psychological stress. By contrast, systolic and diastolic BP did not show significant time*group interactions and did not predict cognitive vulnerability during TSD. Conclusion HRV differed between resilient and vulnerable individuals across TSD, psychological stress and recovery sleep and predicted individual differences in cognitive performance, whereby lower HRV during full-rested conditions predicted resilience to TSD and TSD + psychological stress. HRV, but not BP, is a reliable biomarker of sleep deprivation, psychological stress, and neurobehavioral vulnerability. Support NASA NNX14AN49G.

scholarly journals Altered hippocampal transcriptome dynamics following sleep deprivation

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Marie E. Gaine ◽  
Ethan Bahl ◽  
Snehajyoti Chatterjee ◽  
Jacob J. Michaelson ◽  
Ted Abel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sleep Deprivation ◽  
Rna Splicing ◽  
Public Health Problem ◽  
The United States ◽  
Postsynaptic Membrane ◽  
Protein Coding ◽  
Recovery Sleep ◽  
Behavioral Studies ◽  
Acute Sleep Deprivation

AbstractWidespread sleep deprivation is a continuing public health problem in the United States and worldwide affecting adolescents and adults. Acute sleep deprivation results in decrements in spatial memory and cognitive impairments. The hippocampus is vulnerable to acute sleep deprivation with changes in gene expression, cell signaling, and protein synthesis. Sleep deprivation also has long lasting effects on memory and performance that persist after recovery sleep, as seen in behavioral studies from invertebrates to humans. Although previous research has shown that acute sleep deprivation impacts gene expression, the extent to which sleep deprivation affects gene regulation remains unknown. Using an unbiased deep RNA sequencing approach, we investigated the effects of acute sleep deprivation on gene expression in the hippocampus. We identified 1,146 genes that were significantly dysregulated following sleep deprivation with 507 genes upregulated and 639 genes downregulated, including protein coding genes and long non-coding RNAs not previously identified as impacted by sleep deprivation. Notably, genes significantly upregulated after sleep deprivation were associated with RNA splicing and the nucleus. In contrast, downregulated genes were associated with cell adhesion, dendritic localization, the synapse, and postsynaptic membrane. Furthermore, we found through independent experiments analyzing a subset of genes that three hours of recovery sleep following acute sleep deprivation was sufficient to normalize mRNA abundance for most genes, although exceptions occurred for some genes that may affect RNA splicing or transcription. These results clearly demonstrate that sleep deprivation differentially regulates gene expression on multiple transcriptomic levels to impact hippocampal function.

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