scholarly journals Optical coherence tomography of arteriolar diameter and capillary perfusion during spreading depolarizations

2021 ◽  
pp. 0271678X2199401
Author(s):  
Maryam Anzabi ◽  
Baoqiang Li ◽  
Hui Wang ◽  
Sreekanth Kura ◽  
Sava Sakadžić ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Capillary Flow ◽  
Hemodynamic Response ◽  
Optical Coherence ◽  
Capillary Perfusion ◽  
Pial Arteries ◽  
Primary Mechanism ◽  
Mouse Cortex ◽  
Capillary Bed ◽  
Arteriolar Diameter

Spreading depolarization (SD) is associated with profound oligemia and reduced oxygen availability in the mouse cortex during the depolarization phase. Coincident pial arteriolar constriction has been implicated as the primary mechanism for the oligemia. However, where in the vascular bed the hemodynamic response starts has been unclear. To resolve the origin of the hemodynamic response, we used optical coherence tomography (OCT) to simultaneously monitor changes in the vascular tree from capillary bed to pial arteries in mice during two consecutive SDs 15 minutes apart. We found that capillary flow dropped several seconds before pial arteriolar constriction. Moreover, penetrating arterioles constricted before pial arteries suggesting upstream propagation of constriction. Smaller caliber distal pial arteries constricted stronger than larger caliber proximal arterioles, suggesting that the farther the constriction propagates, the weaker it gets. Altogether, our data indicate that the hemodynamic response to cortical SD originates in the capillary bed.

scholarly journals Imaging hemodynamic response after ischemic stroke in mouse cortex using visible-light optical coherence tomography

2016 ◽  
Vol 7 (9) ◽  
pp. 3377 ◽  
Author(s):  
Siyu Chen ◽  
Qi Liu ◽  
Xiao Shu ◽  
Brian Soetikno ◽  
Shanbao Tong ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Ischemic Stroke ◽  
Visible Light ◽  
Hemodynamic Response ◽  
Optical Coherence ◽  
Mouse Cortex

Vascular findings in primarily affected and fellow eyes of middle-aged patients with Coats’ disease using multimodal imaging

2020 ◽  
pp. bjophthalmol-2020-317101
Author(s):  
Claudia Brockmann ◽  
Julia Löwen ◽  
Shideh Schönfeld ◽  
Mirjam Rossel-Zemkouo ◽  
Ira Seibel ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Multimodal Imaging ◽  
Clinical Investigation ◽  
Optical Coherence ◽  
Aged Patients ◽  
Vascular Abnormalities ◽  
Fundus Imaging ◽  
Coats Disease ◽  
Capillary Bed ◽  
Fellow Eyes

AimsTo investigate the retinal vascular structure and capillary anomalies of affected and fellow eyes of patients with unilateral Coats’ disease using multimodal imaging.MethodsClinical investigation of both eyes of each patient with diagnosed Coats’ disease using ultra-widefield (UWF) fundus imaging, including UWF fluorescein angiography (UWFFA), spectral domain optical coherence tomography (OCT) and optical coherence tomography angiography (OCT-A).ResultsWe analysed 38 eyes of 19 patients with unilateral Coats’ disease and found that all fellow eyes (19/19; 100%) revealed vascular alterations, detected by UWFFA, predominantly located in the temporal periphery. Thereby, 89% of the fellow eyes (17/19) presented capillary bed abnormalities, that did not exceed the capillary level; 58% (11/19) presented tortuous abnormalities and 26% (5/19) presented microaneurysmatic abnormalities, exceeding the capillary level. If primarily affected eyes presented central Coats’ specific vascular abnormalities, fellow eyes revealed tortuous vascular abnormalities twice as often (78% (7/9) vs 40% (4/10); P=0.096). In primarily affected eyes, a tendency towards larger foveal avascular zones was revealed, compared to fellow eyes (0.28±0.16 mm2 vs 0.20±0.10 mm2; P=0.123).ConclusionThe use of modern multimodal imaging allows the detection of even subtle vascular changes in fellow eyes of patients with Coats’ disease. Coats’ disease appears to be a bilateral ocular disease with a predominant manifestation in one eye of the affected patients.

scholarly journals Exploring the association of collaterals and vessel density using optical coherence tomography angiography in retinal vein occlusions

2019 ◽  
Author(s):  
Hee Eun Lee ◽  
Yiyang Wang ◽  
Alaa E. Fayed ◽  
Amani A. Fawzi
Keyword(s):  
Optical Coherence Tomography ◽  
Clustering Algorithm ◽  
Optical Coherence Tomography Angiography ◽  
Vessel Density ◽  
P Value ◽  
Study Cohort ◽  
Optical Coherence ◽  
Capillary Perfusion ◽  
Cross Sectional ◽  
Entire Study

AbstractPurposeUsing optical coherence tomography angiography (OCTA) to characterize the types of collaterals in eyes with retinal vein occlusion (RVO) and further investigate their correlations with vessel densities of the superficial (SCP) and the deep capillary plexus (DCP).MethodsThis cross-sectional study included 25 eyes of 23 patients with RVO. 3 × 3 mm2 OCTA macular scans were used to quantify the parafoveal vessel density (VD) of the SCP and DCP, and to classify the collaterals into one of four types (true superficial, true deep, superficial diving, and foveal collateral). Poisson regression model was used to identify significant associations between parafoveal VD and collaterals. We further compared parafoveal VD between subgroups classified by the presence of specific collateral types based on the results of a clustering algorithm.Results16 of 25 eyes (64%) developed collaterals. Of the 43 collateral vessels analyzed, 12/19 (63%) true superficial collaterals developed in eyes with central RVO, while all 10 superficial diving collaterals (100%) developed in eyes with branch RVO. Located exclusively in the SCP, true superficial collaterals were all arteriovenous (A-V), while diving collaterals were all veno-venular (V-V). We found a significant negative correlation between SCP VD and the total number of collaterals (R2 = 0.648, P < 0.001) for the entire study cohort. Furthermore, BRVO eyes that developed superficial diving collaterals and CRVO eyes that developed true superficial collaterals demonstrated statistically significant decrease in SCP VD (P-value = 0.014) and DCP VD (P-value = 0.030), respectively, as compared to their counterparts.ConclusionOur data shows that decreased capillary perfusion in RVO is associated with the development of collaterals, while the RVO type largely dictates the type of collateral that ultimately develops.

Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study

2020 ◽  
Vol 104 (10) ◽  
pp. 1435-1442
Author(s):  
Mohamed I Geneid ◽  
Janne J Uusitalo ◽  
Ilmari L Leiviskä ◽  
Ville O Saarela ◽  
M Johanna Liinamaa
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Retinal Vessel ◽  
Vessel Diameter ◽  
Macular Thickness ◽  
Optical Coherence ◽  
Middle Aged ◽  
Macular Volume ◽  
Rnfl Thickness ◽  
Arteriolar Diameter

AimsStudying the relationship between retinal vessel diameter (RVD) with (1) macular thickness and volume, (2) retinal nerve fibre layer (RNFL), (3) ganglion cell-inner plexiform layer (GC-IPL) and (4) optic nerve head (ONH) in a population cohort of middle-aged Caucasians.MethodsWe collected data from 3070 individuals. We used a semiautomated computer-assisted programme to measure central retinal arteriolar equivalent and central retinal venular equivalent. Macular and ONH parameters were assessed by optical coherence tomography.ResultsData from 2155 persons were analysed. A larger RVD was associated with a thicker macula and increased macular volume; each SD increase in average macular thickness and volume was associated with a 3.28 µm and a 3.19 µm increase in arteriolar diameter and a 5.10 µm and a 5.08 µm increase in venular diameter, respectively (p<0.001 for all). A larger rim area, greater GC-IPL and RNFL thicknesses were associated with larger RVD; each SD increase in rim area, GC-IPL thickness and RNFL thickness was associated with a 1.21 µm, 2.68 µm and a 3.29 µm increase in arteriolar diameter and a 2.13 µm, 4.02 µm and 5.04 µm increase in venular diameter, respectively (p<0.001 for all).ConclusionsIncreased macular thickness, macular volume, GC-IPL thickness, RNFL thickness and optic nerve rim area were associated with larger RVDs in all subjects. This study clarified the anatomical correlations between both macular and ONH parameters with RVD for middle-aged Caucasians; these can represent a basis for further studies investigating the vascular aetiology of eye diseases.

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