Diagnostic performance of CT-guided percutaneous transthoracic core needle biopsy using low tube voltage (100 kVp): comparison with conventional tube voltage (120 kVp)

Background Computed tomography (CT)-guided percutaneous transthoracic core needle biopsy (PTNB) is typically performed at 120 kVp tube voltage. However, there is no study that has demonstrated diagnostic performance including ground-glass nodules and radiation dose reduction at lower tube voltage in large population. Purpose To retrospectively compare the diagnostic performance and radiation dose between 100 kVp and 120 kVp during CT-guided PTNB. Material and Methods This study included 393 PTNBs performed in 385 patients (Group I; 120 kVp) from March 2011 to September 2011 and 1368 PTNBs performed in 1318 patients (Group II; 100 kVp) from October 2011 to December 2013. The patients underwent CT-guided PTNB with the coaxial technique. Diagnostic performance, complication rate, and radiation dose were compared between two groups. Results Technical success was achieved in 391 of 393 PTNBs (99.5%) in Group I and in 1344 of 1368 PTNBs (98.2%) in Group II ( P = 0.09). The diagnostic accuracies for pulmonary lesions were not significantly different between two groups (97.1% [362/373] versus 96.2% [1202/1249], P = 0.458). Complication rate showed no significant differences between two groups in terms of pneumothorax (19.7% [77/391] versus 19.4% [261/1344], P = 0.904) and hemoptysis (2.3% [9/391] versus 3.2% [43/1344], P = 0.360). Among patients who developed pneumothorax, three patients (3.9%, 3/77) in Group I and eight patients (3.1%, 8/261) in Group II required treatment with drainage catheter. Nobody needed further treatment for hemoptysis in the two groups. The mean radiation dose was 1.5 ± 1.9 mSv in Group I and 0.7 ± 0.3 mSv in Group II ( P < 0.001). Conclusion The 100-kVp protocol for CT-guided PTNB showed significant benefit of radiation dose reduction while maintaining high diagnostic accuracy and safety.

Download Full-text

CT-guided transthoracic core needle biopsy for small pulmonary lesions: diagnostic performance and adequacy for molecular testing

Journal of Thoracic Disease ◽

10.21037/jtd.2017.02.16 ◽

2017 ◽

Vol 9 (2) ◽

pp. 333-343 ◽

Cited By ~ 24

Author(s):

Panwen Tian ◽

Ye Wang ◽

Lei Li ◽

Yongzhao Zhou ◽

Wenxin Luo ◽

...

Keyword(s):

Core Needle Biopsy ◽

Needle Biopsy ◽

Diagnostic Performance ◽

Molecular Testing ◽

Ct Guided ◽

Core Needle ◽

Pulmonary Lesions

Download Full-text

Percutaneous Imaging-Guided versus Open Musculoskeletal Biopsy: Concepts and Controversies

Seminars in Musculoskeletal Radiology ◽

10.1055/s-0040-1717113 ◽

2020 ◽

Vol 24 (06) ◽

pp. 667-675

Author(s):

Violeta Vasilevska Nikodinovska ◽

Slavcho Ivanoski ◽

Milan Samardziski ◽

Vesna Janevska

Keyword(s):

Soft Tissue ◽

Complication Rate ◽

Core Needle Biopsy ◽

Multidisciplinary Team ◽

Gold Standard ◽

Needle Biopsy ◽

Soft Tissue Tumors ◽

Open Biopsy ◽

Core Needle ◽

Similar Accuracy

AbstractBone and soft tissue tumors are a largely heterogeneous group of tumors. Biopsy of musculoskeletal (MSK) tumors is sometimes a challenging procedure. Although the open biopsy is still considered the gold standard for the biopsy of MSK lesions, core needle biopsy can replace it in most cases, with similar accuracy and a low complication rate. The biopsy should be performed in a tertiary sarcoma center where the multidisciplinary team consists of at minimum a tumor surgeon, an MSK pathologist, and an MSK radiologist who can assess all steps of the procedure. Several factors can influence the success of the biopsy including the lesion characteristics, the equipment, and the method used for the procedure. This review highlights some of the important aspects regarding the biopsy of the MSK tumors, with special attention to imaging a guided core needle biopsy and highlighting some of the recent advancements and controversies in the field.

Download Full-text

Factors to consider when comparing the diagnostic performance of fine-needle aspiration and core-needle biopsy for thyroid nodules

Endocrine ◽

10.1007/s12020-020-02562-4 ◽

2021 ◽

Author(s):

Dong Gyu Na

Keyword(s):

Fine Needle Aspiration ◽

Core Needle Biopsy ◽

Needle Biopsy ◽

Diagnostic Performance ◽

Thyroid Nodules ◽

Needle Aspiration ◽

Core Needle ◽

Fine Needle

Download Full-text

Diagnostic Accuracy of CT-Guided Core Needle Biopsy for Solitary Bone Lesions in Pediatric Patients

10.1055/s-0040-1722507 ◽

2020 ◽

Author(s):

A. Vidoni ◽

A. Saifuddin

Keyword(s):

Diagnostic Accuracy ◽

Core Needle Biopsy ◽

Needle Biopsy ◽

Pediatric Patients ◽

Bone Lesions ◽

Ct Guided ◽

Core Needle

Download Full-text

Value of CT-guided core-needle biopsy in diagnosis and classification of malignant lymphomas using automated biopsy gun

World Journal of Gastroenterology ◽

10.3748/wjg.v11.i31.4843 ◽

2005 ◽

Vol 11 (31) ◽

pp. 4843 ◽

Cited By ~ 22

Author(s):

Li Li

Keyword(s):

Core Needle Biopsy ◽

Needle Biopsy ◽

Malignant Lymphomas ◽

Ct Guided ◽

Core Needle ◽

Diagnosis And Classification

Download Full-text

Percutaneous Core Needle Biopsy Can Efficiently and Safely Diagnose Most Primary Bone Tumors

Diagnostics ◽

10.3390/diagnostics11091552 ◽

2021 ◽

Vol 11 (9) ◽

pp. 1552

Author(s):

Vincent Crenn ◽

Léonard Vezole ◽

Amine Bouhamama ◽

Alexandra Meurgey ◽

Marie Karanian ◽

...

Keyword(s):

Complication Rate ◽

Core Needle Biopsy ◽

Needle Biopsy ◽

Bone Tumors ◽

First Line ◽

Surgical Biopsy ◽

Core Needle ◽

Reference Center ◽

Referral Center ◽

Percutaneous Core Needle Biopsy

A biopsy is a prerequisite for the diagnosis and evaluation of musculoskeletal tumors. It is considered that surgical biopsy provides a more reliable diagnosis because it can obtain more tumor material for pathological analysis. However, it is often associated with a significant complication rate. Imaging-guided percutaneous core needle biopsy (PCNB) is now widely used as an alternative to surgical biopsy; it appears to be minimally invasive, possibly with lower complication rates. This study evaluates the diagnostic yield of the preferred use of PCNB in a referral center, its accuracy, and its complication rate. The data relating to the biopsy and the histological analysis were extracted from the database of a bone tumor reference center where PCNB of bone tumors was discussed as a first-line option. 196 bone tumors were biopsied percutaneously between 2016 and 2020. They were located in the axial skeleton in 21.4% (42) of cases, in the lower limb in 58.7% (115), and in the upper limb in 19.9% (39) cases. We obtained a diagnosis yield of 84.7% and a diagnosis accuracy of 91.7%. The overall complication rate of the percutaneous biopsies observed was 1.0% (n = 2), consisting of two hematomas. PCNB performed in a referral center is a safe, precise procedure, with a very low complication rate, and which avoids the need for first-line open surgical biopsy. The consultation between pathologist, radiologist, and clinician in an expert reference center makes this technique an effective choice as a first-line diagnosis tool.

Download Full-text