Similarity and diversity of spontaneous brain activity in functional dyspepsia subtypes

2019 ◽  
Vol 61 (7) ◽  
pp. 927-935 ◽  
Author(s):  
Rongfeng Qi ◽  
Zhao Shi ◽  
Yifei Weng ◽  
Yulin Yang ◽  
Yifei Zhou ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Epigastric Pain ◽  
Brain Activity ◽  
Pearson Correlation ◽  
Pain Syndrome ◽  
Posterior Cingulate Cortex ◽  
Healthy Controls ◽  
Spontaneous Brain Activity ◽  
Epigastric Pain Syndrome ◽  
The Right

Background Functional dyspepsia (FD) subtypes may differ in terms of pathophysiology, but the underlying mechanisms remain poorly understood. Purpose To explore spontaneous brain activity in two main FD subtypes, namely epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS), using the amplitude of low-frequency fluctuation (ALFF). Material and Methods Thirty-one FD patients (18 EPS and 13 PDS) and 22 matched healthy controls (HC) underwent resting-state functional MRI scanning. Spontaneous brain activity was evaluated by measuring the ALFF and then compared among the EPS, PDS, and HC groups with ANOVA test. Pearson correlation analysis was performed between the ALFF values and clinical indices. Results Compared to healthy controls, both EPS and PDS patients had increased ALFF in the bilateral precentral/postcentral gyri, insula, and thalami. Furthermore, only the EPS patients displayed increased ALFF in the right middle and inferior frontal gyri, and only the PDS patients showed increased ALFF in the left posterior cingulate cortex (PCC). The ALFF values in the left thalamus were positively correlated with the sleep disturbance in EPS patients, and the ALFF values in the right precentral/postcentral gyri showed a positive correlation with the symptom score in PDS patients. Conclusion EPS and PDS had similarities of higher spontaneous brain activity in the primary motor/sensory areas and homeostatic-afferent network regions, and differences in the prefrontal region and PCC, providing evidence to suggest the similarity and diversity of pathophysiology in FD subtypes.

Fasting and Postprandial Gastric Sensorimotor Activity in Functional Dyspepsia: Postprandial Distress Vs. Epigastric Pain Syndrome

2014 ◽  
Vol 109 (10) ◽  
pp. 1631-1639 ◽  
Author(s):  
Michele Di Stefano ◽  
Emanuela Miceli ◽  
Paola Tana ◽  
Caterina Mengoli ◽  
Manuela Bergonzi ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Epigastric Pain ◽  
Pain Syndrome ◽  
Epigastric Pain Syndrome ◽  
Sensorimotor Activity

scholarly journals The effect of acotiamide on epigastric pain syndrome and postprandial distress syndrome in patients with functional dyspepsia

2016 ◽  
Vol 63 (3.4) ◽  
pp. 230-235 ◽  
Author(s):  
Satoshi Shinozaki ◽  
Hiroyuki Osawa ◽  
Hirotsugu Sakamoto ◽  
Yoshikazu Hayashi ◽  
Alan Kawarai Lefor ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Distress Syndrome ◽  
Epigastric Pain ◽  
Pain Syndrome ◽  
Postprandial Distress Syndrome ◽  
Epigastric Pain Syndrome

scholarly journals Level of proinflammatory cytokines in children with various clinical forms of functional dyspepsia

2019 ◽  
Keyword(s):  
Gastric Mucosa ◽  
Functional Dyspepsia ◽  
Epigastric Pain ◽  
Pain Syndrome ◽  
Endoscopic Examination ◽  
Control Group ◽  
Total Group ◽  
Tnf Α ◽  
Epigastric Pain Syndrome ◽  
Pro Inflammatory Cytokines

Objective was to study the level of tumor necrosis factor α (TNF-α) and interleukin 1α (IL-1α) in the blood of children with various forms of functional dyspepsia in accordance with various endoscopic changes of the gastric mucosa. Materials and methods. 79 school age children with functional dyspepsia were examined. The diagnosis was made in accordance with the recommendations of the Rome Criteria IV (2016). All patients underwent endoscopic examination of the esophagus, stomach and duodenum to exclude destructive changes of the mucous membrane. The level of TNF-α and IL-1α in the blood serum was determined by enzyme immunoassay. Statistical processing of the results obtained was performed using Microsoft Excel 2010. Results. The average level of TNF-α in the total group was 463.22±27.4 pg/ml, which statistically significantly exceeded this indicator in the control group (26.76±1.10 pg/ml; p<0.01). The IL-1α value in the total group was 148.6±6.06 pg/ml and was significantly higher in comparison with the control group (53.29±3.28 pg/ml; p<0.01). The level of proinflammatory cytokines in the group of children with epigastric pain syndrome was significantly higher than in the group of children with postprandial distress syndrome. Endoscopic examination showed the presence of unchanged mucous membrane in only 25.3% of children. Erythematous gastroduodenopathy was observed in 74.7% of children and was typical mainly for patients with epigastric pain syndrome (97.7%; p<0.05). Conclusions. The level of pro-inflammatory cytokines in children with functional dyspepsia is increased. When comparing the clinical variants of the disease, a significant increase in the level of TNFα, and IL-1α in children with epigastric pain syndrome was found. In the same group of children, endoscopic changes in the gastric mucosa were more pronounced. Further study of changes in the level of pro-inflammatory cytokines in children with functional dyspepsia may allow this to be used as one of the methods for the differential diagnosis of functional dyspepsia and chronic gastritis.

891 Up-Regulation of Gastric TRPV1 mRNA Expression in Functional Dyspepsia Patients of Epigastric Pain Syndrome Subtype

2014 ◽  
Vol 146 (5) ◽  
pp. S-157
Author(s):  
Yoon Jin Choi ◽  
Nayoung Kim ◽  
Jinjoo Kim ◽  
Sung Wook Hwang ◽  
Ryoung Hee Nam ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Functional Dyspepsia ◽  
Epigastric Pain ◽  
Pain Syndrome ◽  
Epigastric Pain Syndrome

scholarly journals Prevalence of dyspeptic symptoms and heartburn of adults in Belo Horizonte, Brazil

2017 ◽  
Vol 54 (1) ◽  
pp. 46-50 ◽  
Author(s):  
Alessandra Maciel ALMEIDA ◽  
Luísa Alvarenga Guerra MARTINS ◽  
Patrícia Liz Terenzi CUNHA ◽  
Viviane Willig BRASIL ◽  
Lucas Galuppo Fernandes FÉLIX ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Eating Habits ◽  
Epigastric Pain ◽  
Pain Syndrome ◽  
Postprandial Fullness ◽  
Epigastric Pain Syndrome ◽  
Dyspeptic Symptoms ◽  
Rome Iii ◽  
Belo Horizonte ◽  
Social Demographic

ABSTRACT BACKGROUND Medical literature has shown dyspepsia and heartburn-related symptoms occur among 15% to 40% of the population. These symptoms can occur at any age and are more prevalent in women. OBJECTIVE Investigate the prevalence of dyspeptic symptoms and heartburn among individuals over 18. METHODS Individuals over 18 were randomly selected in public venues in Belo Horizonte/MG to participate. A standardized questionnaire that included questions related to social-demographic characteristics, eating habits, digestive symptoms, medical appointments, medications, exams, previous surgeries and comorbidities was applied. A questionnaire about functional dyspepsia diagnosis (Rome III) was also applied. RESULTS A total of 548 individuals were interviewed. Among these, 58.4% were women, 59.3% were white, 55.9% were single and the average age was 36 years. Within this group, 376 individuals (68.6%) declared to have some symptom and/or use medication to relieve dyspepsia symptoms, and for these patients were applied the Rome III questionnaire. Based on the diagnostic criteria for the questionnaire proposed by the Rome III consensus, the symptom of postprandial fullness was reported by 6.7% of the individuals, early satiety (3.5%) and epigastric pain (10.6%). The overlap of these symptoms was very frequent. The prevalence of functional dyspepsia was 10.6% (postprandial discomfort syndrome (8.2%) and epigastric pain syndrome (2.4%). Among all participants, 52.5% reported heartburn, and 11.1% presented this symptom at least once a week. The most used drug was omeprazole. CONCLUSION The prevalence of dyspeptic symptoms and heartburn among a Brazilian adult urban population is similar to those described in other countries.

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