Quantified small bowel motility in patients with ulcerative colitis and gastrointestinal symptoms: a pilot study

Background Gastrointestinal (GI) symptoms are common in patients with ulcerative colitis (UC), even when the disease is in remission, possibly due to abnormalities in GI motility. Small bowel motility can be assessed globally and in specific intestinal regions during magnetic resonance enterography (MRE) using a displacement mapping technique. Purpose To investigate whether small bowel motility in MRE differs between patients with UC and controls, and if altered motility correlates with GI symptoms. Material and Methods In 2016–2018, patients who were admitted for MRE, regardless of clinical indication, were consecutively invited to the study. Healthy volunteers were recruited. The participants completed a questionnaire regarding GI symptoms and relevant clinical data were reviewed in the medical records. The dynamic imaging series obtained during MRE were sent for motility mapping and a motility index (MI) was calculated in jejunum, ileum and terminal ileum in all participants. Results In total, 224 patients and healthy volunteers were enrolled in the study. Fifteen were diagnosed with UC and 22 were considered healthy controls. In UC, the prevalence of GI symptoms was higher than in controls ( P < 0.001), both in remission and in active disease. There was no correlation between GI symptoms and small bowel motility in UC. Jejunal motility was lower in UC than in controls ( P = 0.049). Conclusion Jejunal motility is decreased in UC compared with healthy controls, but there is no relationship between small bowel motility and GI symptoms in UC.

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Small bowel motility during nutrition with enteral formulas containing peptides and intact protein in healthy volunteers

Clinical Nutrition ◽

10.1016/0261-5614(92)90245-l ◽

1992 ◽

Vol 11 ◽

pp. 63 ◽

Cited By ~ 3

Author(s):

N. Bein ◽

M. Kemen ◽

H.-H. Homann ◽

K.H. Bauer ◽

V. Zumtobel

Keyword(s):

Small Bowel ◽

Healthy Volunteers ◽

Intact Protein ◽

Bowel Motility ◽

Small Bowel Motility ◽

Enteral Formulas

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Comparative quantitative assessment of global small bowel motility using magnetic resonance imaging in chronic intestinal pseudo-obstruction and healthy controls

Neurogastroenterology & Motility ◽

10.1111/nmo.12735 ◽

2015 ◽

Vol 28 (3) ◽

pp. 376-383 ◽

Cited By ~ 26

Author(s):

A. Menys ◽

S. Butt ◽

A. Emmanuel ◽

A. A. Plumb ◽

A. Fikree ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Small Bowel ◽

Quantitative Assessment ◽

Healthy Controls ◽

Resonance Imaging ◽

Bowel Motility ◽

Small Bowel Motility ◽

Intestinal Pseudo Obstruction

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Magnetic resonance imaging of the gastrointestinal tract shows reduced small bowel motility and altered chyme in cystic fibrosis compared to controls

10.1101/2021.02.15.21251749 ◽

2021 ◽

Author(s):

Neele S Dellschaft ◽

Christabella Ng ◽

Caroline Hoad ◽

Luca Marciani ◽

Robin Spiller ◽

...

Keyword(s):

Cystic Fibrosis ◽

Small Bowel ◽

Bacterial Overgrowth ◽

Healthy Controls ◽

Colon Mucosa ◽

Ascending Colon ◽

Resonance Imaging ◽

Bowel Motility ◽

Small Bowel Motility ◽

Mri Scans

AbstractCystic fibrosis (CF) is a genetic disease affecting mucosal secretions. Most patients experience digestive symptoms, but the mechanisms are incompletely understood. Here we explore causes and consequences of slower gastrointestinal transit using magnetic resonance imaging (MRI).Twelve people with CF and 12 healthy controls, matched for age and gender, underwent MRI scans both fasted and after standardised meals over a period of 6.5 hours. Images were assessed for small bowel motility, longitudinal relaxation time (T1) of ascending colon chyme, chyme texture and appearance of the colon wall.Small bowel motility scores were significantly lower in CF than in healthy controls in the fasting state (CF median 40 arbitrary units IQR [31, 46] vs Control 86 a.u. [52, 106], P=0.034). This difference was less pronounced postprandially. Furthermore, ascending colon chyme T1 was lower in CF than in controls (CF 0.59 s [0.38, 0.77] vs Control 0.79 s [0.55, 1.31], P=0.010). The difference in texture between small bowel and colon chyme, seen in health, was diminished in CF (difference in Haralick contrast 0.90 a.u. [0.38, 1.67] vs Control 2.11 a.u. [0.71, 3.30], P=0.010). Ascending colon mucosa in CF participants had an abnormal appearance compared to controls (Score 1-3, CF 2 [1, 3] vs Controls 1 [1, 1], P=0.019).Reduced small bowel motility and water content of ascending colon chyme are consistent with slower transit and constipation. MRI provides unique insights into chyme texture in the small bowel (suggesting bacterial overgrowth) and the appearance of the colon mucosa (suggesting altered mucus) in CF.Key point summary-People with cystic fibrosis (CF) have intrusive digestive symptoms and severe gut complications, but mechanisms are incompletely understood.-In this study, 12 people with CF were compared to healthy controls, undergoing repeated MRI scans before and after standardised meals.-Fasted small bowel motility is reduced in people with CF, consistent with slower transit. In addition, a reduced colonic chyme water content and abnormal appearance of small bowel and colonic chyme as well as colonic mucosa suggest small bowel bacterial overgrowth, fat malabsorption and abnormal mucus production-These MRI outcomes hold promise in the assessment of therapeutic interventions.

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