Ultrasonically Guided Fine Needle Aspiration of Suggested Enlarged Parathyroid Glands

1988 ◽  
Vol 29 (2) ◽  
pp. 213-216 ◽  
Author(s):  
S. Karstrup ◽  
A. Glenthøj ◽  
S. Torp-Pedersen ◽  
L. Hegedüs ◽  
H. H. Holm
Keyword(s):  
Fine Needle Aspiration ◽  
Thyroid Tissue ◽  
Parathyroid Tissue ◽  
Needle Aspiration ◽  
Parathyroid Glands ◽  
Histologic Examination ◽  
Fine Needle

Ultrasonically guided fine needle aspiration from 22 ultrasonically suspect enlarged parathyroid glands was performed in 21 consecutive patients with biochemically confirmed hyperparathyroidism. Histologic examination revealed parathyroid tissue in 20 and thyroid tissue in 2 of the 22 ultrasonically suspect parathyroid glands. The aspirated material (21 patients) was analysed for PTH content and compared with the PTH content in aspirates from corresponding thyroid tissue. In all but one, a higher PTH content was found in aspirates from parathyroid glands. Further, the aspirated material (16 patients) was cytologically examined for parathyroid cells. In 10 of 14 histologically confirmed parathyroid glands cells of parathyroid origin were found, but in 4 cases only cells of endocrine origin were seen. The results and the use of fine needle aspiration in relation to the ultrasonic findings are discussed.

scholarly journals Diagnostic importance of CD56 with fine-needle aspiration cytology in suspected papillary thyroid carcinoma cases

CytoJournal ◽  
2018 ◽  
Vol 15 ◽  
pp. 3 ◽  
Author(s):  
Ozgen Arslan Solmaz
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Fine Needle Aspiration ◽  
Thyroid Nodules ◽  
Histopathological Examination ◽  
Adult Population ◽  
Thyroid Tissue ◽  
Needle Aspiration ◽  
Papillary Thyroid ◽  
Fine Needle

Background: Palpable thyroid nodules can be found in 4%–7% of the adult population; however, <5% of thyroid nodules are malignant. Immunohistochemical markers, such as CD56, can be used to make a differential diagnosis between benign and malignant lesions. To increase the accuracy of the diagnosis and distinguish the malignant aspirates from the benign ones, chose to evaluate CD56, which is normally found in benign thyroid tissue. Methods: A total of 53 fine-needle aspirate samples from patients diagnosed with suspected papillary thyroid carcinoma (PTC) were included prospectively. These aspirates were immunocytochemically stained for CD56. Results: In histopathological examination, the fine-needle aspiration cytopathology specimens suspicious for PTC (after undergoing surgery) showed that 32 (60.4%) were benign and 21 (39.6%) were malignant. Thirty-one of the benign cases (96.87%) were CD56-positive, whereas the last case (3.13%) was CD56-negative. Staining was not seen in any of the malignant cases. Conclusions: We believe that CD56 is an important marker in the definitive diagnosis of suspected PTC cases, with CD56-positivity being interpreted in favor of benignity.

Histopathological changes in thyroid tissue after fine needle aspiration biopsy

2007 ◽  
Vol 203 (9) ◽  
pp. 641-645 ◽  
Author(s):  
Filiz Bolat ◽  
Fazilet Kayaselcuk ◽  
Tarık Z. Nursal ◽  
Mehmet Reyhan ◽  
Nebil Bal ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
Thyroid Tissue ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Histopathological Changes ◽  
Fine Needle ◽  
Needle Aspiration Biopsy

scholarly journals Intraoperative Fine Needle Aspiration Parathyroid Hormone Assay Can Be Used as an Alternative to Frozen Section Analysis for the Identification of Parathyroid Tissue

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S43-S44
Author(s):  
A D Olivas ◽  
X M van Wijk ◽  
P Angelos
Keyword(s):  
Parathyroid Hormone ◽  
Fine Needle Aspiration ◽  
Frozen Section ◽  
Parathyroid Tissue ◽  
Needle Aspiration ◽  
Fisher Exact Test ◽  
Tissue Samples ◽  
Fine Needle ◽  
Frozen Section Analysis ◽  
Section Analysis

Abstract Introduction/Objective Histologic frozen section analysis is typically used for parathyroid tissue identification during parathyroidectomy when needed, in conjunction with a rapid intraoperative plasma parathyroid hormone (PTH) assay to confirm falling levels of circulating PTH after parathyroid excision. As an alternative to frozen section consults, we hypothesize that automated analysis of intraoperative fine needle aspiration (ioFNA) tissue samples using a rapid PTH immunoassay can accurately identify parathyroid tissue and reduce the need for frozen section consults. Methods A rapid PTH immunoassay (Elecsys PTH STAT; Roche Diagnostics, Indianapolis, IN), currently used for intraoperative plasma samples, was validated for FNA samples on a Cobas® e411 using tissue aspirates of ex vivo parathyroid and control specimens rinsed in 1mL saline. ioFNA PTH results during parathyroidectomy were then prospectively assessed for accuracy over a 4-month period by comparing values to final histopathologic diagnoses. The number of frozen section consults requested was compared to a 5-month period prior to the availability of the ioFNA PTH assay. Results Ninety patients underwent parathyroidectomy (128 excised parathyroids) during the study period, performed by a single experienced endocrine surgeon. Indications included primary (81/90), tertiary (5/90), and recurrent (4/90) hyperparathyroidism. Thirty-nine cases (55.5 excised parathyroids) were performed after the availability of the ioFNA PTH assay. ioFNA samples were sent for PTH analysis in 7/39 cases (18%; 12 samples total) and had a sensitivity/specificity of 100% (parathyroid [n=7] PTH values 1968 - &gt;5000pg/mL; non-parathyroid [n=5] PTH values &lt;2 - 16pg/mL). Parathyroidectomies requiring frozen section consult significantly decreased from 41% (21/51 cases; 40 specimens) to 10% (4/39 cases; 9 specimens) with the availability of the ioFNA PTH assay (p&lt; 0.05, Fisher exact test). Conclusion Analysis of ioFNA tissue samples using an automated rapid PTH immunoassay can accurately identify parathyroid tissue and can be used as an alternative to frozen section consult when needed.

scholarly journals Role of parathyroid hormone measurement in fine-needle aspiration biopsy washout in diagnosis and treatment of primary hyperparathyroidism

2018 ◽  
Vol 20 (3) ◽  
pp. 108-113
Author(s):  
Dmitry G. Beltsevich ◽  
Valeriy V. Voskoboynikov ◽  
Camila M. Klycheva ◽  
Anna A. Roslyakova ◽  
Daria O. Ladygina
Keyword(s):  
Thyroid Gland ◽  
Primary Hyperparathyroidism ◽  
Fine Needle Aspiration ◽  
Thyroid Nodules ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Parathyroid Glands ◽  
Aspiration Biopsy ◽  
Fine Needle ◽  
Needle Aspiration Biopsy

In this article, we discuss difficulties in parathyroid localization modalities in diagnosis of primary hyperparathyroidism. Most often, superior parathyroid glands are located on the posteromedial surface of the right and left lobes of the thyroid gland, however, they also could be found at the carotid bifurcation, behind pharynx and esophagus, as well as inside thyroid gland. Location of the inferior parathyroid glands is more variable: on the side or back surface, or below the lower pole of the thyroid gland, as well as in thymus, posterior or anterior mediastinum, or inside thyroid. Localization modalities of primary hyperparathyroidism are based on neck ultrasonography, scintigraphy with sestamibi, computed tomography of neck and mediastinum. In cases with combination of multinodal goitre and an intrathyroid location of the parathyroid gland, there might be additional difficulties in verification of various patterns (thyroid nodules or parathyroid glands). In this article, we present two clinical cases of intrathyroid location of parathyroid glands. The algorithm of parathyroid adenoma localization is shown. Determination of PTH level in washing liquid after fine-needle aspiration biopsy from necessary punctures of the nodule formations, which can be either intrathyroid parathyroid glands or thyroid nodules, can also help to avoid diagnostic mistakes.

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