Diagnostic yield of percutaneous core needle biopsy in suspected soft tissue lesions of extremities

Objective This retrospective study was performed to investigate the diagnostic yield of percutaneous core needle biopsy (CNB) for suspected soft tissue lesions of the extremities. Methods The medical records of 139 consecutive patients who underwent percutaneous CNB for suspected soft tissue lesions of the extremities from January 2014 to December 2016 at a single institution were reviewed. The pathologic findings or clinical follow-ups were used to evaluate the performance of CNB. Alterations in the treatment regimen from pre- to post-biopsy were also analyzed. Complications, when present, were documented. Results In total, 141 biopsy procedures were performed in 139 patients. In total, 136 (96%) biopsies were successful, among which 5 were false-negative and 131 were diagnosed accurately. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of CNB in the differentiation of malignant from benign lesions were 94%, 100%, 96%, 100%, and 90%, respectively. The treatment regimen was altered based on the biopsy findings in 25 cases. Two patients developed mild nerve injury but fully recovered during follow-up. Conclusions CNB is effective and safe, with high sensitivity, specificity, and accuracy for the diagnosis of soft tissue lesions, especially for differentiating malignant from benign lesions.

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A comparative clinicopathological study between ultrasonography, mammography, FNAC and core needle biopsy of breast lump

10.21203/rs.3.rs-28882/v1 ◽

2020 ◽

Author(s):

Arnab Mandal ◽

Pradipta Jana ◽

Sabyasachi Bakshi ◽

Ram Krishna Mandal

Keyword(s):

Core Needle Biopsy ◽

Predictive Value ◽

Needle Biopsy ◽

Breast Disease ◽

Ultra Sound ◽

Benign Lesions ◽

Breast Lump ◽

Core Needle ◽

Carcinoma Breast ◽

Sensitivity Specificity

Abstract BACKGROUND:Early presentation and prompt diagnosis is the essential key in treatment of different variety of neoplastic as well as non-neoplastic breast disease. In this study usefulness of HRUSG, Mammography, FNAC and Core Needle Biopsy in correlation with histopathological pattern, was assessed.METHODS:After matching the criteria, 212 cases, were taken for this prospective, single center, observational study. RESULTS:Out of 212 cases, 163(76.88 %%) were benign lesions, 49(23.11%) were malignant and 1(0.47%) were of inflammatory pathology. Benign to malignant breast disease ratio was 3.3:1. Out of 49 malignant cases, 45 (91.83%) were ductal cell carcinoma and 4 (8.16%) was apocrine carcinoma. Maximum numbers of cancer patients were found in the 51- 60 year age groups.The sensitivity, specificity, Positive predictive value and Negative Predictive value of mammography in detecting carcinoma breast were 87.76%, 64.71%, 87.76% and 64.71% respectively. The sensitivity, specificity, PPV and NPV of HRUSG in detecting carcinoma breast were 85.71%, 90.18%, 72.41% and 95.45% respectively.Among benign lesions, 47 (28.83) % were diagnosed by mammography and 147(90.18) % were diagnosed by HRUSG. When these modalities were combined, >95% of the lesions was diagnosed accurately.CONCLUSIONS:Ultra sound used liberally as an adjunct to mammography, increase the cancer detection rate. Core needle biopsy is found more accurate but FNAC have limited value in evaluation of benign breast lump. This study also proves that preoperative categorization of breast lesions is utmost important for management of the patient and this will help to avoid unnecessary surgical treatment.

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Faculty Opinions recommendation of Bone and soft-tissue lesions: what factors affect diagnostic yield of image-guided core-needle biopsy?

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1141921.599029 ◽

2009 ◽

Author(s):

Jose Narvaez ◽

Matias De Albert

Keyword(s):

Soft Tissue ◽

Core Needle Biopsy ◽

Needle Biopsy ◽

Diagnostic Yield ◽

Core Needle ◽

Soft Tissue Lesions ◽

Image Guided

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Bone and Soft-Tissue Lesions: What Factors Affect Diagnostic Yield of Image-guided Core-Needle Biopsy?

Radiology ◽

10.1148/radiol.2483071742 ◽

2008 ◽

Vol 248 (3) ◽

pp. 962-970 ◽

Cited By ~ 114

Author(s):

Jim S. Wu ◽

Jeffrey D. Goldsmith ◽

Perry J. Horwich ◽

Sanjay K. Shetty ◽

Mary G. Hochman

Keyword(s):

Soft Tissue ◽

Core Needle Biopsy ◽

Needle Biopsy ◽

Diagnostic Yield ◽

Core Needle ◽

Soft Tissue Lesions ◽

Image Guided

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The diagnostic value of ultrasound-guided percutaneous core needle biopsy of musculoskeletal soft tissue lesions

Journal of Ultrasonography ◽

10.15557/jou.2021.0004 ◽

2021 ◽

Vol 21 (84) ◽

pp. e22-e33

Author(s):

Paweł Szaro ◽

◽

Andrew Wong ◽

Elena Blain ◽

Khaldun Ghali Gataa ◽

...

Keyword(s):

Soft Tissue ◽

Core Needle Biopsy ◽

Needle Biopsy ◽

Diagnostic Value ◽

Ultrasound Guided ◽

Core Needle ◽

Soft Tissue Lesions ◽

Percutaneous Core Needle Biopsy ◽

Malignant Lesions ◽

Solid Lesions

Introduction: Percutaneous ultrasound-guided core needle biopsy is a well-established method in the diagnosis of musculoskeletal tumors. It is unclear which factors contribute the most to a successful biopsy. The aim of the study was to determine the value of ultrasoundguided core needle biopsy of solid lesions in the musculoskeletal system using a 16-gauge needle. Material and methods: A retrospective analysis performed at a regional sarcoma center over one year included patients referred for ultrasound-guided biopsy of musculoskeletal soft tissue lesions. At least 6 months’ clinical and radiological follow-up, results from repeat or excisional biopsy, or interventional treatment, served as outcome reference. The biopsy procedure and yield were analyzed. The biopsy was classified as ‘diagnostic’ when a definitive diagnosis could be made on the first biopsy, and ‘accurate’ when only the malignant or benign nature of the tumor could be determined. Results: From 102 referrals for biopsy of soft tissue lesions in 2019, a total of 73 biopsies of solid lesions with a 16-gauge cutting needle were included (73 patients). There were 34 males and 39 females, with a mean age of 57.7 years. The overall proportion of diagnostic biopsies was 84%, for malignant lesions 88% and benign lesions 81%. The tumor could be classified as malignant or benign in 12 patients (16%) (accurate biopsy). It was possible to discriminate between malignant and benign lesions in each case. The majority of biopsied lesions were benign 64% (n = 47). Conclusion: The diagnostic value of ultrasound-guided percutaneous core needle biopsy of musculoskeletal soft tissue lesions performed with 16-gauge needle is good, with a high rate of diagnostic biopsies, both for benign and malignant lesions.

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Factors influencing diagnostic yield of CT-guided percutaneous core needle biopsy for bone lesions

Clinical Radiology ◽

10.1016/j.crad.2013.09.003 ◽

2014 ◽

Vol 69 (1) ◽

pp. e43-e47 ◽

Cited By ~ 24

Author(s):

Y. Li ◽

Y. Du ◽

T.Y. Luo ◽

H.F. Yang ◽

J.H. Yu ◽

...

Keyword(s):

Core Needle Biopsy ◽

Needle Biopsy ◽

Diagnostic Yield ◽

Bone Lesions ◽

Ct Guided ◽

Core Needle ◽

Factors Influencing ◽

Percutaneous Core Needle Biopsy

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Image-guided percutaneous core needle biopsy of soft-tissue masses in the pediatric population

Pediatric Radiology ◽

10.1007/s00247-016-3571-5 ◽

2016 ◽

Vol 46 (8) ◽

pp. 1173-1178 ◽

Cited By ~ 10

Author(s):

Terrence Metz ◽

Amer Heider ◽

Ranjith Vellody ◽

Marcus D. Jarboe ◽

Joseph J. Gemmete ◽

...

Keyword(s):

Soft Tissue ◽

Core Needle Biopsy ◽

Needle Biopsy ◽

Pediatric Population ◽

Core Needle ◽

Image Guided ◽

Percutaneous Core Needle Biopsy ◽

Soft Tissue Masses

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Small Musculoskeletal Soft-Tissue Lesions: US-guided Core Needle Biopsy—Comparative Study of Diagnostic Yields according to Lesion Size

Radiology ◽

10.1148/radiol.2015142516 ◽

2016 ◽

Vol 278 (1) ◽

pp. 156-163 ◽

Cited By ~ 12

Author(s):

Sang Yoon Kim ◽

Hye Won Chung

Keyword(s):

Soft Tissue ◽

Comparative Study ◽

Core Needle Biopsy ◽

Needle Biopsy ◽

Lesion Size ◽

Core Needle ◽

Soft Tissue Lesions

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A comparative clinicopathological study between ultrasonography, mammography, fine needle aspiration cytology and core needle biopsy of breast lump

International Surgery Journal ◽

10.18203/2349-2902.isj20202844 ◽

2020 ◽

Vol 7 (7) ◽

pp. 2325

Author(s):

Arnab Mandal ◽

Pradipta Jana ◽

Sabyasachi Bakshi ◽

Ram Krishna Mandal

Keyword(s):

Core Needle Biopsy ◽

Predictive Value ◽

Needle Biopsy ◽

Breast Disease ◽

Needle Aspiration ◽

Breast Lump ◽

Aspiration Cytology ◽

Core Needle ◽

Needle Aspiration Cytology ◽

Sensitivity Specificity

Background: Early presentation and prompt diagnosis is the essential key in treatment of different variety of neoplastic as well as non-neoplastic breast disease. In this study usefulness of high-resolution ultrasonography (HRUSG), mammography, fine needle aspiration cytology (FNAC) and core needle biopsy in correlation with histopathological pattern, was assessed.Methods: After matching the criteria, 212 cases, were taken for this prospective, single center, observational study.Results: Out of 212 cases, 163 (76.88%) were benign lesions, 49 (23.11%) were malignant and 1 (0.47%) were of inflammatory pathology. Benign to malignant breast disease ratio was 3.3:1. Out of 49 malignant cases, 45 (91.83%) were ductal cell carcinoma and 4 (8.16%) was apocrine carcinoma. Maximum numbers of cancer patients were found in the 51-60-year age groups. The sensitivity, specificity, positive predictive value and negative predictive value of mammography in detecting carcinoma breast were 87.76%, 64.71%, 87.76% and 64.71% respectively. The sensitivity, specificity, positive predictive value and negative predictive value of HRUSG in detecting carcinoma breast were 85.71%, 90.18%, 72.41% and 95.45% respectively. Among benign lesions, 47 (28.83%) were diagnosed by mammography and 147 (90.18%) were diagnosed by HRUSG. When these modalities were combined, >95% of the lesions was diagnosed accurately.Conclusions: Ultra sound used liberally as an adjunct to mammography, increase the cancer detection rate. Core needle biopsy is found more accurate but FNAC have limited value in evaluation of benign breast lump. This study also proves that preoperative categorization of breast lesions is utmost important for management of the patient and this will help to avoid unnecessary surgical treatment.

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Value of biomarkers in distinguishing indeterminate core needle biopsy samples of thyroid nodules

10.21203/rs.3.rs-22757/v1 ◽

2020 ◽

Author(s):

Yan Xiong ◽

Li Liang ◽

Limin Yan ◽

Dong Li ◽

Xin Li ◽

...

Keyword(s):

Core Needle Biopsy ◽

Predictive Value ◽

Needle Biopsy ◽

Thyroid Nodules ◽

Fine Needle Biopsy ◽

Pathogenic Mutation ◽

Core Needle ◽

Gene Testing ◽

Galectin 3 ◽

Sensitivity Specificity

Abstract Background: Core needle biopsy (CNB) is now more frequently used for the preoperative diagnosis of thyroid nodules. Based on morphology alone, 5%-20% of CNB samples cannot be determined as malignant or benign. Compared to fine-needle biopsy (FNB), samples collected by CNB are more accessible for various tests. Therefore, studying the application of biomarkers in distinguishing indeterminate CNB samples of thyroid nodules is a practical need. Methods: Patients with thyroid nodules with both CNB and matched resected specimens were reviewed. Cases classified as indeterminate lesions, follicular neoplasms and suspicious for malignancy were retrieved. All CNB samples were stained by immunohistochemistry (IHC) using antibodies against CK19, Galectin-3, HBME-1, and CD56 and detected by next-generation sequencing (NGS) using a target panel. With the help of these biomarkers, all CNB samples were reclassified. Taking the classification of resected specimens as the gold standard, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of each biomarker for discriminating malignancy from benignity were calculated. Results: The sensitivity, specificity, PPV, NPV and accuracy were 93.55%, 60.00%, 93.55%, 60.00% and 88.89% for CK19; 93.55%, 40.00%, 90.63%, 50.00% and 86.11% for Galectin-3; 77.42%, 100.00%, 100.00%, 41.67% and 80.56% for HBME-1; 66.13%, 100.00%, 100.00%, 32.26% and 70.83% for CD56; and 91.94%, 100.00%, 100.00%, 66.67% and 93.06% for pathogenic mutation. Conclusions: The application of biomarkers is very effective in distinguishing indeterminate CNB samples of thyroid nodules. Gene testing by NGS using a target panel has very high accuracy. The limitation of tumor quantity is the main reason for the weakened power of NGS. IHC plays an important role in cases with negative NGS results. The combination of NGS and IHC is a reliable “rule in” test for malignancy.

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